November 10, 2022 6:20 AM EST

COVID-19 vaccines work—but immunocompromised individuals may not produce as strong an immune response. Evusheld became the first treatment to protect this group before exposure to the virus when it received emergency authorization from the FDA in December 2021. The antibody therapy—made by AstraZeneca and given by injection to people at high risk of developing serious disease if they get COVID-19—is a combination of two monoclonal antibodies that soak up virus proteins to prevent them from infecting healthy cells. There is a downside of antibody-based treatments like Evusheld, however: viruses can mutate to become resistant to them. The FDA has warned that the therapy might not be as effective with newer Omicron variants compared to previous strains of SARS-CoV-2.

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