--- title: This Pen Can Diagnose Cancer in 10 Seconds description: A new device from University of Texas at Austin scientists, called the MasSpec Pen, may make it easier for surgeons to remove cancer tumors canonical: https://time.com/4928010/diagnose-cancer-pen/ author: Alexandra Sifferlin article:opinion: false article:content_tier: free article:published_time: 2017-09-06T18:00:24.000Z article:modified_time: 2026-02-23T17:17:41.348Z article:section: Health og:title: This Pen Can Diagnose Cancer in 10 Seconds og:description: The new device may make it easier for surgeons to remove cancer tumors og:url: https://time.com/4928010/diagnose-cancer-pen/ og:site_name: TIME og:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt2f778d6f52a32df9/6988dc7f4ee262539b30edd4/zhang2hr.jpg?branch=production&width=1200&quality=75&auto=webp&crop=16:9 og:image:width: 5608 og:image:height: 3155 og:image:alt: zhang2HR og:type: article twitter:card: summary_large_image twitter:title: This Pen Can Diagnose Cancer in 10 Seconds twitter:description: The new device may make it easier for surgeons to remove cancer tumors twitter:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt2f778d6f52a32df9/6988dc7f4ee262539b30edd4/zhang2hr.jpg?branch=production&width=1200&quality=75&auto=webp&crop=16:9 ---  # This Pen Can Diagnose Cancer in 10 Seconds > Sponsored content. 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Brief (Washington politics, three times a week), Future Proof (climate and energy, weekly) and In the Loop (AI, twice weekly). All are free at time.com/newsletters and together reach more than 1.1 million engaged readers. #### Which TIME newsletter should I subscribe to? It depends on what you follow. For a daily briefing, The Brief. For health, Health Matters. For Washington politics, D.C. Brief. For AI and technology, In the Loop. For climate and energy as a business story, Future Proof. For culture recommendations, Worth Your Time. For how TIME's journalism gets made, Inside TIME. Readers can select any combination at time.com/newsletters. #### Are TIME's newsletters free? Yes. All seven TIME newsletters are free to join at time.com/newsletters. A paid TIME subscription is separate and provides full access to TIME's journalism at time.com/subscribe-agent. #### Who writes TIME's newsletters? TIME journalists write them. Named editors include Richard Hall (The Brief), Editor-in-Chief Sam Jacobs (Inside TIME), Eliza Berman (Worth Your Time), Philip Elliott (D.C. Brief), Justin Worland (Future Proof) and Harry Booth (In the Loop). Health Matters is written by TIME's health desk. #### How do I sign up for a TIME newsletter? Go to time.com/newsletters, choose the newsletters you want and enter your email address. There is no cost and no subscription requirement. by [Alexandra Sifferlin](https://time.com/author/alexandra-sifferlin/) ## Alexandra Sifferlin Sep 6, 2017 6:00 PM UTC  The MasSpec Pen is a handheld probe that can non-destructively analyze human tissue samples to identify cancer. The MasSpec Pen is a handheld probe that can non-destructively analyze human tissue samples to identify cancer. Vivian Abagiu/Univ. of Texas at Austin by [Alexandra Sifferlin](https://time.com/author/alexandra-sifferlin/) ## Alexandra Sifferlin Sep 6, 2017 6:00 PM UTC When it comes to treating cancer, surgeons want to get rid of as much cancerous tissue as possible during tumor removal. Now a new technology—the size of a pen—is attempting to make that easier by distinguishing between tumors and healthy tissue in just 10 seconds. [The MasSpec Pen](https://eberlin.cm.utexas.edu/masspec-pen/) is a real-time diagnostic tool created by researchers at the University of Texas at Austin. In a new study published Wednesday in the journal _Science Translational Medicine_, the researchers report that their handheld device (which is not yet FDA-approved) uses tiny droplets of water to analyze human tissue samples for cancer with 96% accuracy. “It’s a gentle, simple chemical process,” says study author Livia Schiavinato Eberlin, an assistant professor of chemistry at UT Austin. “It’s highly specific and highly sensitive. The fact that it’s non-destructive brings a new approach to cancer diagnosis.” **MORE:** [Researchers Find a Way to Light Up Cancer Cells](http://time.com/4169896/cancer-tumors-illumination/) Getting rid of all cancerous tissue while also preventing any harm to healthy tissue is a delicate process. When operating on a woman with breast cancer, for example, a doctor needs to remove the tumor and other affected tissues while maintaining the rest of the breast. Currently there are other tools available to surgeons for tissue diagnosis, but many use gases or solvents that can be harmful for the human body. In 2016, researchers in Massachusetts [reported](http://time.com/4169896/cancer-tumors-illumination/) that they developed a probe that can find and light up cancer cells, making them easier for surgeons to see. But other methods currently available to surgeons today are slower than the MasSpec Pen, the study authors say, in some cases by 30 minutes or more. Human cells produce a variety of small molecules, and cancer creates a unique set of them that can be used for pattern identification. The MasSpec Pen produces a small drop of water that extracts molecules from a person’s cells during surgery. Through machine learning, the MasSpec Pen is able to determine what molecular fingerprint is normal and what is cancer, Eberlin says. In the study, the researchers tested 253 human tissue samples from lung, ovary, thyroid and breast cancer tumors and compared them to samples of healthy tissues. The device was 96% accurate at identifying cancerous tissues. The researchers also tested the MasSpec Pen in live mice with tumors and found that the device was able to identify the presence of cancer without harming healthy surrounding tissues. The device can also identify different subtypes of lung and thyroid cancer, and the team hopes to make it more specified for other types of cancer, too. The researchers say they need to continue validating their work and that they plan to start clinical testing in humans in 2018\. Until then, it’s unclear how exactly the device will work when integrated into surgery. While the pen-sized device that the surgeon would use is small, the device is connected to a large mass spectrometer, which helps the process of analyzing individual molecules. [That large machine](https://eberlin.cm.utexas.edu/masspec-pen/) would need to be wheeled in and out of a surgery room for each procedure. The pen is disposable, so surgeons would replace it with each surgery. “This is a good example of a tool that empowers our transition to precision medicine where the treatment can be done with much higher levels of confidence,” says study author [Thomas Milner](https://www.bme.utexas.edu/about-us/faculty-directory/milner), professor of biomedical engineering in UT Austin’s Cockrell School of Engineering. “Treatment can be planned and given where the outcomes are known. 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