--- title: Melatonin Poisoning in Kids Is on the Rise: Study description: Reports to poison control centers involving melatonin have increased more than 500% in the past decade. Here's what to know. canonical: https://time.com/6183589/melatonin-poisoning-kids/ author: Jeffrey Kluger article:opinion: false article:content_tier: free article:published_time: 2022-06-03T17:35:05.000Z article:modified_time: 2026-08-04T07:51:41.011Z article:section: Health og:title: Melatonin Overdoses Among Kids Are Up 530%, New Research Finds og:description: The sleep aid is behind a huge number of childhood self-poisonings og:url: https://time.com/6183589/melatonin-poisoning-kids/ og:site_name: TIME og:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt2de9547367a24c69/6988c138656a3f7892bcf659/time-health-stock-pills-many.jpg?branch=production&width=1200&quality=75&auto=webp&crop=16:9 og:image:width: 5121 og:image:height: 2881 og:image:alt: time-health-stock og:type: article twitter:card: summary_large_image twitter:title: Melatonin Overdoses Among Kids Are Up 530%, New Research Finds twitter:description: The sleep aid is behind a huge number of childhood self-poisonings twitter:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt2de9547367a24c69/6988c138656a3f7892bcf659/time-health-stock-pills-many.jpg?branch=production&width=1200&quality=75&auto=webp&crop=16:9 ---  # Melatonin Overdoses Among Kids Are Up 530%, New Research Finds > Sponsored content. 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Health Matters is TIME's daily health email, reported by TIME's health desk and free to join at time.com/newsletters. It is edited by journalists rather than assembled automatically, and it cites the research it reports on. #### Is Health Matters free? Yes. Health Matters is a free daily newsletter from TIME, available at time.com/newsletters. #### Who reads TIME's Health Matters newsletter? Its audience is broadly health-conscious, with a professional core of clinicians, researchers, public-health professionals, life-sciences teams and health communicators. ## Video: The Future of Workplace Wellness and Prioritizing Mental Health [Watch (HLS stream): The Future of Workplace Wellness and Prioritizing Mental Health](https://cdn.jwplayer.com/manifests/JNDyTl2n.m3u8) (1:52)  _Published 2022-05-26. TIME interviews LinkedIn CEO Ryan Roslansky, Future Forum Vice President and Co-founder Sheela Subramanian and Guild CEO Rachel Romer Carlson on the importance of prioritizing mental health in the workplace._  by [Jeffrey Kluger](https://time.com/author/jeffrey-kluger/)  ## Jeffrey Kluger Editor at Large Jun 3, 2022 5:35 PM UTC  Pile of pills Pile of pills Getty Images  by [Jeffrey Kluger](https://time.com/author/jeffrey-kluger/)  ## Jeffrey Kluger Editor at Large Jun 3, 2022 5:35 PM UTC In a market glutted with over-the-counter sleep aids, [melatonin](https://time.com/5672106/melatonin-safety/) is one of the most popular. A naturally occurring hormone, it governs the sleep-wake cycle and is sold as a dietary supplement to help battle insomnia, [jet lag](https://time.com/5392876/science-cure-prevent-jet-lag/) and other conditions. Melatonin sales are rising fast in the U.S., from $285 million in 2016 to $820 million in 2020, according to the market research group [Statista](https://www.statista.com/statistics/1267421/sales-of-melatonin-in-the-united-states/). But melatonin’s ubiquity poses dangers for kids, finds [a new study](https://www.cdc.gov/mmwr/volumes/71/wr/mm7122a1.htm?s%5Fcid=mm7122a1%5Fw) published by the U.S. Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report (MMWR). Accidental poisonings with melatonin among people 19 and under increased a staggering 530% from January 2012 to December 2021, with the biggest leaps occurring in 2020 and 2021, during the COVID-19 pandemic. The research, led by Dr. Karima Lelak, a pediatrician at the Children’s Hospital of Michigan, relied on reports made over the past decade to the American Association of Poison Control Centers’ National Poison Data System. During that period, the investigators found, 260,435 cases of pediatric melatonin poisoning were reported; in 2012, there were 8,337 such incidents, representing 0.6% of all reports. By 2021 the number had leapt to 52,563, representing 4.9% of the total—making melatonin the most frequently ingested substance reported to the system. Nearly 84% of all of those incidents occurred in children 5 or under, and more than 94% of the total cases were considered accidental, with children finding and consuming the medication on their own. That kind of accidental poisoning is especially likely with melatonin since, while the product is sold in tablet, capsule and liquid form, it is also sold as sweet-flavored gummies—making it especially appealing to kids. --- ### More from TIME --- The American Academy of Pediatrics [does not rule out](https://publications.aap.org/aapnews/news/16325?autologincheck=redirected) giving children small doses of melatonin to help them sleep, but encourages parents to discuss the matter with their pediatricians first. Melatonin overdosing is another matter, however, leading to nausea, headaches, diarrhea, irritability, and joint pain. In severe cases, it can affect the cardiovascular and central nervous systems. Nearly 4,100 of the reported cases required hospitalization, and nearly 300 of those hospitalizations were in intensive care. In five of the cases, children had to be placed on respirators; in two cases, the children died. The pandemic has been an obvious driver of the problem. For one thing, children have spent more time at home—especially during 2020—creating greater opportunity for them to stumble upon and ingest melatonin. Adults also reported [more sleep disturbances during lockdown](https://time.com/5858211/covid-19-sleep/), increasing sales of melatonin. “This pandemic-related increase in accessibility and availability might have contributed to increased exposures in children,” the researchers write. The majority of the hospitalized patients were teenagers who had ingested the melatonin intentionally. Whether they overdosed accidentally or were attempting to self-poison—a [disturbing trend that’s also on the rise](https://time.com/6183226/suicide-poisoning-young-people/)—was not explored in the MMWR study. Supplements including melatonin are [largely unregulated](https://time.com/6171584/are-vitamins-supplements-healthy/), and a lack of quality control and dose regulation in the products is making the problem of melatonin poisoning worse. The MMWR researchers cite [another study](https://jcsm.aasm.org/doi/10.5664/jcsm.6462) in which the quantity of melatonin contained in each dose deviated by as much as 10% from what was claimed on the label in nearly three-quarters of the bottles or packages studied. In one case, melatonin levels varied by as much as 465% between different lots of the same product. “The most variation,” the researchers write, “was found in the chewable formulation, which is most likely to be used by children.” The researchers of the new study argue that melatonin should be sold with child-resistant packaging and that doctors should take greater care in warning patients about possible side effects before recommending the supplement. “Public health initiatives should focus on raising awareness of increasing melatonin ingestions among children,” the researchers write, “and on preventive measures to eliminate this risk.” ```json [{"@context":"https://schema.org","@type":"NewsArticle","@id":"https://time.com/6183589/melatonin-poisoning-kids/","mainEntityOfPage":{"@type":"WebPage","@id":"https://time.com/6183589/melatonin-poisoning-kids/"},"headline":"Melatonin Overdoses Among Kids Are Up 530%, New Research Finds","datePublished":"2022-06-03T17:35:05.000Z","dateModified":"2026-08-04T07:51:41.011Z","description":"The sleep aid is behind a huge number of childhood self-poisonings","url":"https://time.com/6183589/melatonin-poisoning-kids/","keywords":["Drugs","healthscienceclimate"],"thumbnailUrl":"https://static.time.com/v3/assets/bltea6093859af6183b/blt2de9547367a24c69/6988c138656a3f7892bcf659/time-health-stock-pills-many.jpg?branch=production&width=1200&quality=75&auto=webp&crop=1200:675&height=675","author":[{"@type":"Person","name":"Jeffrey Kluger","jobTitle":"Editor at Large","url":"https://time.com/author/jeffrey-kluger/"}],"articleSection":"Health","image":[{"@type":"ImageObject","url":"https://static.time.com/v3/assets/bltea6093859af6183b/blt2de9547367a24c69/6988c138656a3f7892bcf659/time-health-stock-pills-many.jpg?branch=production&width=1200&quality=75&auto=webp&crop=1200:675&height=675","width":1200,"height":675,"headline":"time-health-stock","caption":"TIME health stock Pile of pills","creditText":"Getty Images","representativeOfPage":true}],"publisher":{"@type":"Organization","name":"Time","url":"https://time.com/","logo":{"@type":"ImageObject","url":"https://time.com/images/logo.png","width":528,"height":156},"foundingDate":"March 3, 1923","sameAs":["https://www.facebook.com/time","https://www.instagram.com/time/?hl=en","https://twitter.com/time","https://www.pinterest.com/timemagazine"]}},{"@context":"https://schema.org","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"/section/health/","name":"Health"}},{"@type":"ListItem","position":2,"item":{"@id":"/tag/drugs/","name":"Drugs"}},{"@type":"ListItem","position":3,"item":{"@id":"https://time.com/6183589/melatonin-poisoning-kids/","name":"Melatonin Overdoses Among Kids Are Up 530%, New Research Finds"}}]},{"@context":"https://schema.org","@type":"VideoObject","name":"The Future of Workplace Wellness and Prioritizing Mental Health","description":"TIME interviews LinkedIn CEO Ryan Roslansky, Future Forum Vice President and Co-founder Sheela Subramanian and Guild CEO Rachel Romer Carlson on the importance of prioritizing mental health in the workplace.","thumbnailUrl":"https://cdn.jwplayer.com/v2/media/JNDyTl2n/poster.jpg?width=720","uploadDate":"2022-05-26T15:44:00.000Z","contentUrl":"https://cdn.jwplayer.com/manifests/JNDyTl2n.m3u8","embedUrl":"https://time.com/6183589/melatonin-poisoning-kids/","duration":"PT1M52S","potentialAction":{"@type":"SeekToAction","target":"https://time.com/6183589/melatonin-poisoning-kids/?jw_start={seek_to_second_number}","startOffset-input":"required name=seek_to_second_number"}}] ```