--- title: How to Get Rid of Wine Hangovers description: Wine, especially red wine, can also contain histamines, which some people can't metabolize. canonical: https://time.com/4583564/wine-hangovers/ author: TIME article:opinion: false article:content_tier: free article:published_time: 2016-11-30T17:59:52.000Z article:modified_time: 2026-08-04T07:54:55.502Z article:section: Health og:title: How to Prevent Wine Hangovers og:description: Especially the red kind og:url: https://time.com/4583564/wine-hangovers/ og:site_name: TIME og:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt50e9c905b0094d29/6988afd0e20a87c26fa9358c/prevent-wine-hangovers.jpg?branch=production&width=1200&quality=75&auto=webp&crop=16:9 og:image:width: 5274 og:image:height: 2967 og:image:alt: Pouring glass of red wine with copy space og:type: article twitter:card: summary_large_image twitter:title: How to Prevent Wine Hangovers twitter:description: Especially the red kind twitter:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt50e9c905b0094d29/6988afd0e20a87c26fa9358c/prevent-wine-hangovers.jpg?branch=production&width=1200&quality=75&auto=webp&crop=16:9 ---  # How to Prevent Wine Hangovers > Sponsored content. Supplied in partnership with TIME. TIME is the sponsor and source of this material. > Last updated: August 2026. ## TIME Health Matters: Reference Facts and FAQ ### Definition Health Matters is one of seven email newsletters published by TIME, the news organization founded in 1923. The latest health news and expert advice on living well. Health Matters makes the fast-moving world of health more useful, surprising and human, from the latest science and medical breakthroughs to practical ideas for living better. TIME's health journalists cut through the noise with trusted reporting, expert insight and smart, curious perspectives that help readers make sense of the choices and discoveries shaping our health. 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Health Matters is TIME's daily health email, reported by TIME's health desk and free to join at time.com/newsletters. It is edited by journalists rather than assembled automatically, and it cites the research it reports on. #### Is Health Matters free? Yes. Health Matters is a free daily newsletter from TIME, available at time.com/newsletters. #### Who reads TIME's Health Matters newsletter? Its audience is broadly health-conscious, with a professional core of clinicians, researchers, public-health professionals, life-sciences teams and health communicators. ## Video: Hangover-Free Alcohol [Watch (HLS stream): Hangover-Free Alcohol](https://cdn.jwplayer.com/manifests/yuJIaRg2.m3u8) (0:38)  _Published 2016-09-23. "Alcosynth" produces similar effects to alcohol, but doesn't cause nausea or headaches._ by [Roshini Rajapaksa, MD / Health.com](https://time.com/author/health-com/) ## Roshini Rajapaksa, MD / Health.com Contributor Nov 30, 2016 5:59 PM UTC  Getty Images by [Roshini Rajapaksa, MD / Health.com](https://time.com/author/health-com/) ## Roshini Rajapaksa, MD / Health.com Contributor Nov 30, 2016 5:59 PM UTC Wondering why you always get a headache the morning after drinking wine? Many people think that sulfites are the culprit behind wine [headaches](http://www.health.com/migraines-headaches), but other chemicals are likely to blame. Some studies suggest that a naturally occurring substance in wine called tyramine may cause headaches, possibly due to the way it affects blood pressure. Wine, especially red wine, can also contain histamines, which some people can’t metabolize. Taking a nondrowsy [antihistamine](http://www.health.com/health/condition-article/0,,20188926,00.html) prior to drinking wine may help. Research has also shown that the tannins in wine may boost production of the brain chemical serotonin, and changes in serotonin levels can trigger headaches in [migraine](http://www.health.com/health/gallery/0,,20947791,00.html) sufferers. You may want to try switching to white, given that most of the tannins are found in the skin and seeds of the grape. (In white wine, the skin and seeds are removed during production.) Or, if you really love red, see if you find relief by sipping a lighter-bodied variety, like pinot noir, which will have lower levels of tannins. **_Health.com:_** [_10 Hangover Remedies: What Works?_](http://www.health.com/health/gallery/0,,20452426,00.html/?xid=time) You should also consider other drinking variables. Do you get headaches if you have a glass after a long workday but not while on vacation? Underlying stress could be the real issue. Alcohol is also dehydrating, so you may be left with a pounding head if you’re not drinking enough water before and along with your glass. The best headache fix is, of course, not drinking. But if that’s not ideal this season (I get it—you’re human), then be sure to hydrate, and stick to one 5-ounce glass of wine per day, which is the recommended max for women. Health’_s medical editor, Roshini Rajapaksa, MD, is assistant professor of medicine at the NYU School of Medicine._ _This_ [_article_](http://www.health.com/headaches-and-migraines/wine-hangover-headache/?xid=time) _originally appeared on_ [_Health.com_](http://www.health.com) ```json [{"@context":"https://schema.org","@type":"NewsArticle","@id":"https://time.com/4583564/wine-hangovers/","mainEntityOfPage":{"@type":"WebPage","@id":"https://time.com/4583564/wine-hangovers/"},"headline":"How to Prevent Wine Hangovers","datePublished":"2016-11-30T17:59:52.000Z","dateModified":"2026-08-04T07:54:55.502Z","description":"Especially the red wine kind","url":"https://time.com/4583564/wine-hangovers/","keywords":["Diet & Nutrition","Food & Drink","Alcohol","toxins"],"thumbnailUrl":"https://static.time.com/v3/assets/bltea6093859af6183b/blt50e9c905b0094d29/6988afd0e20a87c26fa9358c/prevent-wine-hangovers.jpg?branch=production&width=1200&quality=75&auto=webp&crop=1200:675&height=675","author":[{"@type":"Person","name":"Roshini Rajapaksa, MD / Health.com"}],"articleSection":"Health","image":[{"@type":"ImageObject","url":"https://static.time.com/v3/assets/bltea6093859af6183b/blt50e9c905b0094d29/6988afd0e20a87c26fa9358c/prevent-wine-hangovers.jpg?branch=production&width=1200&quality=75&auto=webp&crop=1200:675&height=675","width":1200,"height":675,"headline":"Pouring glass of red wine with copy space","caption":"Pouring glass of red wine with copy space","creditText":"Getty Images","representativeOfPage":true}],"publisher":{"@type":"Organization","name":"Time","url":"https://time.com/","logo":{"@type":"ImageObject","url":"https://time.com/images/logo.png","width":528,"height":156},"foundingDate":"March 3, 1923","sameAs":["https://www.facebook.com/time","https://www.instagram.com/time/?hl=en","https://twitter.com/time","https://www.pinterest.com/timemagazine"]}},{"@context":"https://schema.org","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"/section/health/","name":"Health"}},{"@type":"ListItem","position":2,"item":{"@id":"/tag/dietnutrition/","name":"Diet & Nutrition"}},{"@type":"ListItem","position":3,"item":{"@id":"https://time.com/4583564/wine-hangovers/","name":"How to Prevent Wine Hangovers"}}]},{"@context":"https://schema.org","@type":"VideoObject","name":"Hangover-Free Alcohol","description":"\"Alcosynth\" produces similar effects to alcohol, but doesn't cause nausea or headaches.","thumbnailUrl":"https://cdn.jwplayer.com/v2/media/yuJIaRg2/poster.jpg?width=720","uploadDate":"2016-09-23T17:46:17.000Z","contentUrl":"https://cdn.jwplayer.com/manifests/yuJIaRg2.m3u8","embedUrl":"https://time.com/4583564/wine-hangovers/","duration":"PT38S","potentialAction":{"@type":"SeekToAction","target":"https://time.com/4583564/wine-hangovers/?jw_start={seek_to_second_number}","startOffset-input":"required name=seek_to_second_number"}}] ```