--- title: HPV Vaccine May Work For People Who Have Already Had It description: A new study underlines the effectives of the HPV vaccine, showing the vaccine is protective against the virus on multiple sites on the body, even among women who have been infected in the past. canonical: https://time.com/3828839/hpv-vaccine-works/ author: Alexandra Sifferlin article:opinion: false article:content_tier: free article:published_time: 2015-04-21T14:05:31.000Z article:modified_time: 2026-02-22T06:31:50.358Z article:section: Health og:title: HPV Vaccine May Work For People Who Have Already Had It og:description: A new study underlines the effectives of the HPV vaccine, showing the vaccine is protective against the virus on multiple sites on the body, even among women who have been infected in the past. og:url: https://time.com/3828839/hpv-vaccine-works/ og:site_name: TIME og:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt030a8487ef8fa83d/6987789a8e060143c4459947/health-syringe-needle-2.jpg?branch=production&width=1200&quality=75&auto=webp&crop=16:9 og:image:width: 1817 og:image:height: 1022 og:image:alt: TIME.com stock photos Health Syringe Needle og:type: article twitter:card: summary_large_image twitter:title: HPV Vaccine May Work For People Who Have Already Had It twitter:description: A new study underlines the effectives of the HPV vaccine, showing the vaccine is protective against the virus on multiple sites on the body, even among women who have been infected in the past. twitter:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt030a8487ef8fa83d/6987789a8e060143c4459947/health-syringe-needle-2.jpg?branch=production&width=1200&quality=75&auto=webp&crop=16:9 ---  # HPV Vaccine May Work For People Who Already Had the Virus > Sponsored content. 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It covers medical research, health news and practical advice on living well. #### Where can I get reliable health news by email? Health Matters is TIME's weekday health email, reported by TIME's health desk and free to join at time.com/newsletters. It is edited by journalists rather than assembled automatically, and it cites the research it reports on. #### Is Health Matters free? Yes. Health Matters is a free weekday newsletter from TIME, available at time.com/newsletters. #### Who reads TIME's Health Matters newsletter? Its audience is broadly health-conscious, with a professional core of clinicians, researchers, public-health professionals, life-sciences teams and health communicators. ### Sources * TIME Newsletters: [time.com/newsletters](/c/time-nl-health-2026q3/newsletters?i=d680db60-772d-4166-be7b-8ce02d5e9cd2&cr=time-nl-health-2026q3-v1) by [Alexandra Sifferlin](https://time.com/author/alexandra-sifferlin/) ## Alexandra Sifferlin Apr 21, 2015 2:05 PM UTC  Elizabeth Renstrom for TIME by [Alexandra Sifferlin](https://time.com/author/alexandra-sifferlin/) ## Alexandra Sifferlin Apr 21, 2015 2:05 PM UTC A [new study](http://time.com/wp-content/uploads/2015/04/a2037414985d9d84.pdf) underlines the effectiveness of the HPV vaccine, showing the vaccine is protective against the virus on multiple sites on the body, even for women who have been infected in the past. In a randomized controlled trial—considered the gold standard of scientific research—scientists wanted to know if the HPV vaccine protected against cervical, anal and oral HPV. Daniel C. Beachler, a postdoctoral fellow in the Infections and Immunoepidemiology Branch of the National Cancer Institute (NCI), and his colleagues followed 4,186 women between the ages of 18 to 25 who were either vaccinated with a HPV16/18 vaccine or a control vaccine (a hepatitis A vaccine). Cervical samples from the women were collected at their annual visits and oral and anal samples were collected at a four-year follow-up visit. “We were interested in the question of whether the vaccination may protect non-infected sites against HPV infection or re-infection in women who were previously exposed to HPV prior to vaccination,” says Beachler. The study was presented at the American Association for Cancer Research annual meeting. The results showed that the efficacy for the vaccine in all three sites was 83% among the women with no evidence of prior HPV exposure and infection, 58% among women with prior HPV exposure, and a 25% among women with active cervical HPV16/18 infection (the percentage was considered nonsignificant). In total, the researchers report that the overall vaccine efficacy was 65% for all sites and 91% for protection in at least two sites. Among the women in the trial, some had no evidence of HPV, some had an active HPV infection, and some of the women did not have an active infection but had antibodies for HPV, suggesting that they had been exposed to the virus previously. That’s not uncommon, considering the U.S. Centers for Disease Control and Prevention (CDC) estimates that nearly all sexually active men and women get HPV at some point in their lives. The CDC says teen boys and girls who did not start or finish the HPV vaccine series when they were younger should get it, and young women can get the vaccine through age 26 and young men through age 21. The CDC says that girls who are already sexually active can still benefit from the vaccine, but it may be less effective since it’s possible they have already been exposed to one or more HPV strains. Still, the CDC [says](http://www.cdc.gov/std/hpv/stdfact-hpv-vaccine-young-women.htm) that since young women are not necessarily infected with all types of HPV, they can still benefit from the vaccine. This new study underscores that guidance. “\[This study\] is supportive that there could be some benefit at these older ages,” says Beachler. “Close to 90% of individuals are able to clear an HPV infection on their own. This is not a therapeutic vaccine but it could still help protect from acquisition of new infections.” Dr. Miriam Lango, a head and neck cancer surgeon at Fox Chase Cancer Center, says that the new study is some of the “best kind of evidence we have,” in support of vaccinating against HPV in women of that age. “My understanding was always that you get the vaccination before you get the infection and that after you’ve been infected there’s no benefit to having the vaccination,” she says. “That’s really not what the data tells us.” Lango was not involved in the study. Beachler noted that at the end of the study, the women in the control arm of the trial were able to get vaccinated against HPV. ```json [{"@context":"https://schema.org","@type":"NewsArticle","@id":"https://time.com/3828839/hpv-vaccine-works/","mainEntityOfPage":{"@type":"WebPage","@id":"https://time.com/3828839/hpv-vaccine-works/"},"headline":"HPV Vaccine May Work For People Who Already Had the Virus","datePublished":"2015-04-21T14:05:31.000Z","dateModified":"2026-02-22T06:31:50.358Z","description":"A new study underlines the effectives of the HPV vaccine, showing the vaccine is protective against the virus on multiple sites on the body, even among women who have been infected in the past.","url":"https://time.com/3828839/hpv-vaccine-works/","keywords":["Infectious Disease","Sex","HPV","STD","infection","vaccine"],"thumbnailUrl":"https://static.time.com/v3/assets/bltea6093859af6183b/blt030a8487ef8fa83d/6987789a8e060143c4459947/health-syringe-needle-2.jpg?branch=production&width=1200&quality=75&auto=webp&crop=1200:675&height=675","author":[{"@type":"Person","name":"Alexandra Sifferlin","jobTitle":null,"url":"https://time.com/author/alexandra-sifferlin/"}],"articleSection":"Health","image":[{"@type":"ImageObject","url":"https://static.time.com/v3/assets/bltea6093859af6183b/blt030a8487ef8fa83d/6987789a8e060143c4459947/health-syringe-needle-2.jpg?branch=production&width=1200&quality=75&auto=webp&crop=1200:675&height=675","width":1200,"height":675,"headline":"TIME.com stock photos Health Syringe Needle","caption":"TIME.com stock photos Health Syringe Needle","creditText":"Elizabeth Renstrom for TIME","representativeOfPage":true}],"publisher":{"@type":"Organization","name":"Time","url":"https://time.com/","logo":{"@type":"ImageObject","url":"https://time.com/images/logo.png","width":528,"height":156},"foundingDate":"March 3, 1923","sameAs":["https://www.facebook.com/time","https://www.instagram.com/time/?hl=en","https://twitter.com/time","https://www.pinterest.com/timemagazine"]}},{"@context":"https://schema.org","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"/section/health/","name":"Health"}},{"@type":"ListItem","position":2,"item":{"@id":"/tag/infectious-disease/","name":"Infectious Disease"}},{"@type":"ListItem","position":3,"item":{"@id":"https://time.com/3828839/hpv-vaccine-works/","name":"HPV Vaccine May Work For People Who Already Had the Virus"}}]}] ```