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title: Experimental Ebola Vaccine Heads to Human Trials
description: An experimental Ebola vaccine will soon enter phase one of a clinical trial on humans, the National Institute of Health said Thursday.
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author: Alexandra Sifferlin
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article:published_time: 2014-08-28T12:18:20.000Z
article:modified_time: 2026-08-04T08:00:47.618Z
article:section: Health
og:title: Human Trials for Ebola Vaccine are Launching
og:description: An experimental Ebola vaccine will soon enter phase one of a clinical trial on humans, the National Institute of Health said Thursday.
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og:image:alt: Ebola outbreak in Sierra Leone
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twitter:title: Human Trials for Ebola Vaccine are Launching
twitter:description: An experimental Ebola vaccine will soon enter phase one of a clinical trial on humans, the National Institute of Health said Thursday.
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![](https://static.time.com/v3/assets/bltea6093859af6183b/blt24d847e3f29ba7a0/6986a137169ab069bf27aea2/ebola-sierra-leone.jpg?branch=production&width=1200&quality=75&auto=webp&crop=16:9)


# Experimental Ebola Vaccine Heads to Human Trials

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<!-- video src="https://cdn.jwplayer.com/manifests/G194AmTC.m3u8" -->
## Video: Meet The CDC Doctors Fighting Ebola

[Watch (HLS stream): Meet The CDC Doctors Fighting Ebola](https://cdn.jwplayer.com/manifests/G194AmTC.m3u8) (2:32)

![Meet The CDC Doctors Fighting Ebola](https://cdn.jwplayer.com/v2/media/G194AmTC/poster.jpg?width=720)

_Published 2014-08-13. Meet The CDC Doctors Fighting Ebola_


by 

[Alexandra Sifferlin](https://time.com/author/alexandra-sifferlin/)


## Alexandra Sifferlin


Aug 28, 2014 12:18 PM UTC

![A group of young volunteers wear special uniforms for the burial of Ebola victims in Kenema, Sierra Leone on Aug. 24, 2014.](https://static.time.com/v3/assets/bltea6093859af6183b/blt24d847e3f29ba7a0/6986a137169ab069bf27aea2/ebola-sierra-leone.jpg?branch=production&width=1200&quality=75&auto=webp&crop=3:2)

A group of young volunteers wear special uniforms for the burial of Ebola victims in Kenema, Sierra Leone on Aug. 24, 2014.

A group of young volunteers wear special uniforms for the burial of Ebola victims in Kenema, Sierra Leone on Aug. 24, 2014. Mohammed Elshamy—Anadolu Agency/Getty Images

by 

[Alexandra Sifferlin](https://time.com/author/alexandra-sifferlin/)


## Alexandra Sifferlin


Aug 28, 2014 12:18 PM UTC

An experimental Ebola vaccine will soon enter phase one of a clinical trial on humans, the National Institute of Health said Thursday.

Initial testing will take place at the NIH’s Clinical Center in Bethesda, Maryland, while the NIH is in the process of working out tests in Ebola-stricken West Africa. The vaccine was developed by the National Institute of Allergy and Infectious Diseases (NIAID) along with top pharmaceutical company GlaxoSmithKline. The NIH will soon launch other phase one trials of this vaccine as well as another developed by Canada’s Public Health Agency.

The NIAID/GSK vaccine will be tested in a small number of healthy adults who do not have the Ebola virus to see if their bodies create an immune response. The vaccine has already been successfully tested on monkeys.

Here’s how the vaccine works: When a study participant receives the vaccine, one part of the Ebola virus’ genetic material will be delivered to the participants’ cells–but the gene will not replicate. Instead, the cells of the participant will start to express an Ebola protein that will, hopefully, spur an immune response in the participant.

“It is important to know that the Ebola genetic material contained in the investigational vaccine cannot cause a vaccinated individual to become infected with Ebola,” the NIH statement reads. The NIH says simultaneous trials of the NIAID/GSK vaccine and other experimental vaccines will roll out in September.

Testing procedures for experimental Ebola vaccines have been expedited in the wake of the ongoing outbreak in West Africa, which has led to more than a thousand deaths so far. Currently, there is no vaccine or cure for the Ebola virus, though it is survivable with proper treatment.



## Transcript

This Ebola outbreak is unprecedented. This is definitely a marathon and not a sprint. The bugs have evolved. The outbreak has gotten bigger. We are only as strong as the weakest link, and we have learned from Ebola that West Africa was a very weak link. [ MUSIC ] There's small clinics, these are like one room places where sick people might go in their house with maybe an auxiliary nurse as some one who has a little bit of medical training, but defiantly not the same standards that we would have here in the US. We're facing 3 main threats. The first is the threat of new organisms. It was coming and spreading in different places.

The second is drug- resistant bacteria, and the third are intentionally created organisms. What we do in an outbreak response is continuously see how can we make it better. The exercises we've gone through both, re- evaluating our own protocols but also understanding what the public and governmental responses are has really helped us understand. How to take care of these patients in the larger context of our healthcare systems. And, those who are in the building, I would urge you to come down to either the ops team room, or the, When designing a unit that is designed to accept patients with serious communicable diseases, like Ebola, there are ways to design a unit so that it's function.

Functional. Any hospital that can isolate a patient in a single patient room with a bathroom and can follow our infection control recommendations is capable of safely caring for a patient with Ebola. And we've tried to encourage every single hospital in the country to have an antibiotic stewardship program to improve antibiotic prescribing practices. There is a concern about fatigue as we go on that, the CDC other groups have sort of ramping up now to try to surge resources into the area. What we're also realizing is, we need to be able to maintain that surge for many months to keep the pressure on to completely control the outbreak.

Time will tell in the next few weeks if we can start to see those numbers going in the right direction. Fewer new cases each day or each week. The single most important thing to understand about protecting Americans from Ebola is that can best be done by stopping it at the source in Africa. Its normal to be scared of something as deadly as Ebola and for the general public I really hope we can never let our fear undermine our compassion.

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