The first new hotel in decades to open on the shores of Lake Como made a splash in 2016 with its clean, modern aesthetic—the work of Spanish designer Patricia Urquiola, whose custom furnishings appear throughout. Equally stylish are the sleek Riva boats that let guests zip James Bond–style across the lake and work up an appetite for Il Sereno’s newly Michelin-starred restaurant Berton al Lago. —Joseph Hincks