--- title: TIME100 Health: Jerry Mendell description: Find out why Jerry Mendell is on the TIME100 Health list. canonical: https://time.com/collections/time100-health/6966814/jerry-mendell/ article:content_tier: free article:published_time: 2024-05-02T12:15:55.000Z article:modified_time: 2026-03-03T00:31:02.617Z article:section: Health og:title: Jerry Mendell og:description: Find out why Jerry Mendell is on the TIME100 Health list. og:url: https://time.com/collections/time100-health/6966814/jerry-mendell/ og:site_name: TIME og:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt3b08958e57a95a48/698a55f547ca383b353bd711/T100health-2024-Jerry-Mendell.jpg?branch=production&width=1920&quality=75&auto=webp&crop=16:9 og:image:width: 1200 og:image:height: 675 og:image:alt: Jerry Mendell og:type: article twitter:card: summary_large_image twitter:title: Jerry Mendell twitter:description: Find out why Jerry Mendell is on the TIME100 Health list. twitter:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt3b08958e57a95a48/698a55f547ca383b353bd711/T100health-2024-Jerry-Mendell.jpg?branch=production&width=1920&quality=75&auto=webp&crop=16:9 --- May 02, 2024 # Jerry Mendell by [Alice Park](/author/alice-park/) ## Alice Park Senior Correspondent  Jerry Mendell Jerry MendellCourtesy Nationwide Children’s Hospital In the 1960s, Dr. Jerry Mendell saw his first patient with Duchenne muscular dystrophy. More than half a century later, he developed the first treatment that holds back the disease. People with Duchenne are born with a mutation in the dystrophin gene, which makes a protein that’s essential for maintaining healthy muscle. Symptoms typically begin when children are 3 to 6 years old, and get progressively worse, ultimately leading to breathing problems and heart issues as well as the loss of muscle control. While using gene therapy to replace the abnormal gene is the best solution, finding a way to deliver a healthy copy was challenging. Dystrophin is among the largest genes in the body, making it difficult to transport into cells. Mendell studied a related muscle disorder in which people with slightly different mutations in dystrophin were able to maintain healthy muscle and a relatively normal life, then teamed up with Sarepta Therapeutics to find a way to deliver the critical parts of that gene to patients with Duchenne—ultimately coming up with the gene therapy that the U.S. Food and Drug Administration approved in June 2023\. The first young boys treated with the therapy are producing healthier copies of dystrophin, and have not experienced muscle weakness or the other major symptoms of the disease. “We’re not done by any means with perfecting the gene therapy,” says Mendell, who is a senior adviser in the Center for Gene Therapy at Nationwide Children’s Hospital. “This is the opening event, a pioneering event.” ```json [{"@context":"https://schema.org","@type":"Article","@id":"https://time.com/collections/time100-health/6966814/jerry-mendell/","mainEntityOfPage":{"@type":"WebPage","@id":"https://time.com/collections/time100-health/6966814/jerry-mendell/"},"headline":"Jerry Mendell","datePublished":"2024-05-02T12:15:55.000Z","dateModified":"2026-03-03T00:31:02.617Z","description":"","url":"https://time.com/collections/time100-health/6966814/jerry-mendell/","keywords":["time100health2024","franchise","Magazine","Special Project","sponsorshipblock","Accolades"],"thumbnailUrl":"https://static.time.com/v3/assets/bltea6093859af6183b/blt3b08958e57a95a48/698a55f547ca383b353bd711/T100health-2024-Jerry-Mendell.jpg?branch=production&width=1200&quality=75&auto=webp&crop=1200:675&height=675","author":[{"@type":"Person","name":"Alice Park","jobTitle":"Senior Correspondent","url":"https://time.com/author/alice-park/"}],"creator":"Alice Park","articleSection":"Health","image":[{"@type":"ImageObject","url":"https://static.time.com/v3/assets/bltea6093859af6183b/blt3b08958e57a95a48/698a55f547ca383b353bd711/T100health-2024-Jerry-Mendell.jpg?branch=production&width=1200&quality=75&auto=webp&crop=1200:675&height=675","width":1200,"height":675}],"publisher":{"@type":"Organization","name":"Time","url":"https://time.com/","logo":{"@type":"ImageObject","url":"https://time.com/images/logo.png","width":528,"height":156},"foundingDate":"March 3, 1923","sameAs":["https://www.facebook.com/time","https://www.instagram.com/time/?hl=en","https://twitter.com/time","https://www.pinterest.com/timemagazine"]}},{"@context":"https://schema.org","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"/section/health/","name":"Health"}},{"@type":"ListItem","position":2,"item":{"@id":"/tag/time100-health-2024/","name":"time100health2024"}},{"@type":"ListItem","position":3,"item":{"@id":"https://time.com/collections/time100-health/6966814/jerry-mendell/","name":"Jerry Mendell"}}]}] ```