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TIME executive editor Dan Macsai paid tribute to leaders of tomorrow “who defy odds every day” at the TIME 100 Next event Thursday night.

In his opening remarks, Macsai highlighted several of the members of the TIME 100 Next list, including Hong Kong protest leader Edward Leung and Ugandan musician and opposition leader Bobi Wine, along with sexual assault survivors’ advocate Amanda Nguyen.

Read the full transcript of Macsai’s remarks below:

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