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Former President Barack Obama delivered remarks Wednesday at an event sponsored by the Bill & Melinda Gates foundation held in New York City.

The event, called Goalkeepers, was aimed at “accelerating world progress,” its website states. Obama took the stage as the keynote speaker following remarks from Bill and Melinda Gates, Canadian Prime Minister Justin Trudeau, Black Eyed Peas frontman, and more.

Obama touched upon the various global challenges facing the current generation and how young people must remain optimistic in light of increasing issues with “growing economic inequality, a changing climate, terrorism,” and more.

At one point, the former president appeared to call out the GOP for its efforts to dismantle his signature health care policy, saying: “[A]ll of this being done without any demonstrable economic, or actuarial, or plain common sense rationale — it frustrates. And it’s certainly frustrating to have to mobilize every couple months to keep our leaders from inflicting real human suffering on our constituents.”

Read former President Obama’s full speech at the Bill & Melinda Gates Foundation event below:

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