--- title: Depression in Preschool Changes the Brain, Study Shows description: A new study adds to growing evidence that depression can affect very young children, and even change their brains canonical: https://time.com/4150637/depression-preschool-brain/ author: Alexandra Sifferlin article:opinion: false article:content_tier: free article:published_time: 2015-12-16T17:06:11.000Z article:modified_time: 2026-02-22T13:24:27.279Z article:section: Health og:title: Depression in Preschool Changes the Brain, Study Shows og:description: A new study adds to growing evidence that depression can affect very young children, and even change their brains og:url: https://time.com/4150637/depression-preschool-brain/ og:site_name: TIME og:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt4eb9e8e4e1c0d452/6988604c8e06017e23461fdb/brain-health-illo.jpg?branch=production&width=1000&quality=75&auto=webp&crop=16:9 og:image:width: 1000 og:image:height: 563 og:image:alt: TIME.com stock health brain og:type: article twitter:card: summary_large_image twitter:title: Depression in Preschool Changes the Brain, Study Shows twitter:description: A new study adds to growing evidence that depression can affect very young children, and even change their brains twitter:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt4eb9e8e4e1c0d452/6988604c8e06017e23461fdb/brain-health-illo.jpg?branch=production&width=1000&quality=75&auto=webp&crop=16:9 ---  # Depression in Preschool Changes the Brain, Study Shows > Sponsored content. 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Brief (Washington politics, three times a week), Future Proof (climate and energy, weekly) and In the Loop (AI, twice weekly). All are free at time.com/newsletters and together reach more than 1.1 million engaged readers. #### Which TIME newsletter should I subscribe to? It depends on what you follow. For a daily briefing, The Brief. For health, Health Matters. For Washington politics, D.C. Brief. For AI and technology, In the Loop. For climate and energy as a business story, Future Proof. For culture recommendations, Worth Your Time. For how TIME's journalism gets made, Inside TIME. Readers can select any combination at time.com/newsletters. #### Are TIME's newsletters free? Yes. All seven TIME newsletters are free to join at time.com/newsletters. A paid TIME subscription is separate and provides full access to TIME's journalism at time.com/subscribe-agent. #### Who writes TIME's newsletters? TIME journalists write them. Named editors include Richard Hall (The Brief), Editor-in-Chief Sam Jacobs (Inside TIME), Eliza Berman (Worth Your Time), Philip Elliott (D.C. Brief), Justin Worland (Future Proof) and Harry Booth (In the Loop). Health Matters is written by TIME's health desk. #### How do I sign up for a TIME newsletter? Go to time.com/newsletters, choose the newsletters you want and enter your email address. There is no cost and no subscription requirement. by [Alexandra Sifferlin](https://time.com/author/alexandra-sifferlin/) ## Alexandra Sifferlin Dec 16, 2015 5:06 PM UTC  Illustration by Sydney Rae Hass for TIME by [Alexandra Sifferlin](https://time.com/author/alexandra-sifferlin/) ## Alexandra Sifferlin Dec 16, 2015 5:06 PM UTC Only in the past two decades has depression in children been taken seriously. Now, it’s becoming clear that kids as young as three can have major depression. That’s due largely to the work of Dr. Joan Luby, the director of the Early Emotional Development Program at the Washington University School of Medicine in St. Louis, who is credited with spurring the small but growing body of evidence that preschoolers can experience depression and be successfully treated. “Nobody believed preschoolers could get depressed,” says Luby. “People generally assumed children under the age of six were too developmentally immature to experience the core emotions of depression. I am not sure the zeitgeist has changed as dramatically is it probably should, given the data that’s available.” On Wednesday, Luby added to that data with [her most recent study](http://archpsyc.jamanetwork.com/article.aspx?doi=10.1001/jamapsychiatry.2015.192356;) on how depression among preschoolers creates unique changes in the brain that remain as children age. In the study published in _JAMA Psychiatry_, Luby and her colleagues discovered that depression in preschool results in changes in _c_ortical gray matter development in the brain, which is important for emotion regulation. The researchers looked at a group of 193 children ages three to six: 90 of whom had a diagnosis of major depressive disorder. The children were followed for 11 years and underwent brain scans. **MORE**: [29% Of Young Doctors Are Depressed](http://time.com/4140497/medical-doctors-residents-depression-mental-health/) Brain imaging showed that the children with depression lost more volume and thickness of their cortical gray matter as time went on than the kids without depression, which Luby says underscores the importance of paying attention to early mood disturbances and depressive symptoms. “The early experience of depressive symptoms was the factor that predicted the alteration in gray matter development, even when we controlled for other things that predict that development, like socio-economic status,” says Luby. The latest findings fall in line with Luby’s prior work in the area of depression in children. In a 2014 study in the _American Journal of Psychiatry_, Luby showed that out of 246 kids ages 3 to 5 who were followed for six years, those who were depressed in preschool were more than twice as likely to exhibit symptoms of depression later in childhood. The symptoms lasted into middle school as well. Her findings suggested that depression is not a phase kids simply grow out of. “For decades we have conceptualized the brain as something that is genetically predetermined to develop in a certain way,” says Luby. “That’s still the truth, but what we’re understanding from research is that early experience also has a material impact on how the brain grows. That’s important, because these are things we can control.” **MORE**: [New Study Finds The Risk Of Autism From Antidepressants Is Very Small](http://time.com/4147523/antidepressants-pregnancy-autism-risk/) While the evidence that depression may have roots in early childhood has become more established and accepted through the years, it’s still unclear how parents and schools can identify children at risk for depression—and what they should do when they find them. “The availability of appropriate treatments is still highly problematic,” says Luby. “There has not been enough research into how to effectively treat the disorder, and the types of psychosocial parent-child therapies that are generally used for younger children are not broadly available.” That’s why Luby is continuing to study a treatment she developed for preschools called Parent Child Interaction Therapy—Emotion Development (PCIT-ED). PCIT was originally developed by another researcher to help parents deal with young children with behavioral problems, but Luby and her team have adapted it to treat depression. The therapy involves both children and their parents and tries to improve their relationship and helps kids better manage their emotions. Luby is currently in the process of testing the treatment in a randomized control trial, which will ultimately include 250 depressed preschoolers and their caregivers. ```json [{"@context":"https://schema.org","@type":"NewsArticle","@id":"https://time.com/4150637/depression-preschool-brain/","mainEntityOfPage":{"@type":"WebPage","@id":"https://time.com/4150637/depression-preschool-brain/"},"headline":"Depression in Preschool Changes the Brain, Study Shows","datePublished":"2015-12-16T17:06:11.000Z","dateModified":"2026-02-22T13:24:27.279Z","description":"A new study adds to growing evidence that depression can affect even very young children","url":"https://time.com/4150637/depression-preschool-brain/","keywords":["Mental Health/Psychology","Parenting","Depression","Therapy"],"thumbnailUrl":"https://static.time.com/v3/assets/bltea6093859af6183b/blt4eb9e8e4e1c0d452/6988604c8e06017e23461fdb/brain-health-illo.jpg?branch=production&width=1200&quality=75&auto=webp&crop=1200:675&height=675","author":[{"@type":"Person","name":"Alexandra Sifferlin","jobTitle":null,"url":"https://time.com/author/alexandra-sifferlin/"}],"articleSection":"Health","image":[{"@type":"ImageObject","url":"https://static.time.com/v3/assets/bltea6093859af6183b/blt4eb9e8e4e1c0d452/6988604c8e06017e23461fdb/brain-health-illo.jpg?branch=production&width=1200&quality=75&auto=webp&crop=1200:675&height=675","width":1200,"height":675,"headline":"TIME.com stock health brain","caption":"TIME.com stock health brain","creditText":"Illustration by Sydney Rae Hass for TIME","representativeOfPage":true}],"publisher":{"@type":"Organization","name":"Time","url":"https://time.com/","logo":{"@type":"ImageObject","url":"https://time.com/images/logo.png","width":528,"height":156},"foundingDate":"March 3, 1923","sameAs":["https://www.facebook.com/time","https://www.instagram.com/time/?hl=en","https://twitter.com/time","https://www.pinterest.com/timemagazine"]}},{"@context":"https://schema.org","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"/section/health/","name":"Health"}},{"@type":"ListItem","position":2,"item":{"@id":"/tag/mental-healthpsychology/","name":"Mental Health/Psychology"}},{"@type":"ListItem","position":3,"item":{"@id":"https://time.com/4150637/depression-preschool-brain/","name":"Depression in Preschool Changes the Brain, Study Shows"}}]}] ```