Watch the Trailer for the First Post-McDreamy Season of Grey’s Anatomy

In the first trailer for season 12 of Grey’s Anatomy, Meredith (Ellen Pompeo) promises in voice-over that “everything has changed.”

The 21-second spot does not reveal an overwhelming amount of what’s to come, but it’s clear that Meredith’s life is looking a lot different one year following the death of Derek (Patrick Dempsey). Namely, her new roommates have no concept of tidiness — and one of them takes that to extreme when she’s seen swinging a sledgehammer into the wall.

More jarring than that was watching Bailey (Chandra Wilson) straight-up punch a woman in the face while at the hospital, and we have to wonder what would drive her to actual physical violence. What happened in the year since the events in season 11 transpired?

Season 12 debuts Thursday, Sept. 24 at 8 p.m. ET on ABC. For more Grey’s, be sure to check out all the coverage and teasers you could want from our Shondaland issue.

This article originally appeared on EW.com