Twenty-seven seasons in, Springfield is about to get its biggest heartbreak yet—Homer and Marge Simpson are set to legally separate.
According to Al Jean, executive producer of The Simpsons, this season’s premiere features the discovery that Homer Simpson has been suffering from narcolepsy all these years. The new diagnosis sends Homer and Marge’s marriage into a downward spiral, and eventually, the two split up.
Still, the fun is far from over. According to Jean, Homer soon moves on to another woman—his pharmacist, voiced by none other than Girls creator Lena Dunham. “We’ll have cameos from the other women from Girls,” too, Jean told Variety.
This is the second big piece of news Jean has dropped on viewers this week. Simpsons producers at the ATX Festival in Austin on Saturday announced that Sideshow Bob will actually kill Bart Simpson in this year’s annual Halloween episode. And last month, Harry Shearer, who lends his voice to Ned Flanders and Mr. Burns on the show, announced that he would not be returning for its 27th season.
The premiere of the new season is scheduled to air on Fox on Sept. 27.