--- title: Autism and Autism Symptoms: Study Sheds Light on Autism in Girls description: In a new study, researchers seek to better understand what mechanisms are behind the differences between boys and girls with autism canonical: https://time.com/3855645/autism-gender-differences/ author: Alexandra Sifferlin article:opinion: false article:content_tier: free article:published_time: 2015-05-13T00:00:56.000Z article:modified_time: 2026-02-22T07:07:58.907Z article:section: Health og:title: Autism and Autism Symptoms: Study Sheds Light on Autism in Girls og:description: In a new study, researchers seek to better understand what mechanisms are behind the differences between boys and girls with autism og:url: https://time.com/3855645/autism-gender-differences/ og:site_name: TIME og:image: https://static.time.com/v3/assets/bltea6093859af6183b/bltde093bcdab65f2d0/6988d9b9bc6cfc69913e2a3c/time-logo.jpg?branch=production og:image:width: 1200 og:image:height: 675 og:image:alt: TIME og:type: article twitter:card: summary_large_image twitter:title: Autism and Autism Symptoms: Study Sheds Light on Autism in Girls twitter:description: In a new study, researchers seek to better understand what mechanisms are behind the differences between boys and girls with autism twitter:image: https://static.time.com/v3/assets/bltea6093859af6183b/bltde093bcdab65f2d0/6988d9b9bc6cfc69913e2a3c/time-logo.jpg?branch=production --- # Why Autism Is Different in the Brains of Girls Than in Boys > Sponsored content. 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Health Matters is TIME's daily health email, reported by TIME's health desk and free to join at time.com/newsletters. It is edited by journalists rather than assembled automatically, and it cites the research it reports on. #### Is Health Matters free? Yes. Health Matters is a free daily newsletter from TIME, available at time.com/newsletters. #### Who reads TIME's Health Matters newsletter? Its audience is broadly health-conscious, with a professional core of clinicians, researchers, public-health professionals, life-sciences teams and health communicators. by [Alexandra Sifferlin](https://time.com/author/alexandra-sifferlin/) ## Alexandra Sifferlin May 13, 2015 12:00 AM UTC by [Alexandra Sifferlin](https://time.com/author/alexandra-sifferlin/) ## Alexandra Sifferlin May 13, 2015 12:00 AM UTC Autism, already a mysterious disorder, is even more puzzling when it comes to gender differences. For every girl diagnosed with autism, four boys are diagnosed, a disparity researchers don’t yet fully understand. In a new study published in the journal _Molecular Autism_, researchers from the UC Davis MIND Institute tried to figure out a reason why. They looked at 112 boys and 27 girls with autism between ages 3 and 5 years old, as well as a control sample of 53 boys and 29 girls without autism. Using a process called diffusion-tensor imaging, the researchers looked at the corpus callosum — the largest neural fiber bundle in the brain — in the young kids. Prior research has shown differences in that area of the brain among people with autism. They found that the organization of these fibers was different in boys compared with girls, especially in the frontal lobes, which play a role in executive functions. “The sample size is still limited, but this work adds to growing body of work suggesting boys and girls with autism have different underlying neuroanatomical differences,” said study author Christine Wu Nordahl, an assistant professor in the UC Davis Department of Psychiatry and Behavioral Sciences, in an email. In other preliminary research presented at the International Meeting for Autism Research, or IMFAR, in Salt Lake City, the study authors showed that when girls and boys with autism are compared with typically developing boys and girls, the behavioral differences between girls with autism and the female controls are greater than the differences among the boys. Nordahl says this suggests that girls can be more severely affected than boys. A [study](http://time.com/3837896/autism-girls-diagnosis/) earlier this year by a separate group found notable differences in symptoms between autistic boys and girls, which could be one of the reasons autism in girls sometimes goes unnoticed or is diagnosed late. Girls generally display less obvious behavioral symptoms at a young age compared with boys, the researchers found. One of the reasons females with autism are less understood than males is that most research studies do not have equal numbers of boys and girls, says Nordahl. “This is not surprising, given that there are so many more males with autism than females,” she says. “We need to do a better job of trying to recruit females with autism into our studies so that we can fully explore differences between males and females with autism.” Nordahl says understanding gender differences in autism affects how kids are diagnosed, as well as how they are treated. Understanding what biological differences may be at work can ultimately lead to a better understanding of autism and the best interventions for treatment. ```json [{"@context":"https://schema.org","@type":"NewsArticle","@id":"https://time.com/3855645/autism-gender-differences/","mainEntityOfPage":{"@type":"WebPage","@id":"https://time.com/3855645/autism-gender-differences/"},"headline":"Why Autism Is Different in the Brains of Girls Than in Boys","datePublished":"2015-05-13T00:00:56.000Z","dateModified":"2026-02-22T07:07:58.907Z","description":"The reasons why girls are less often diagnosed may be both biological and social","url":"https://time.com/3855645/autism-gender-differences/","keywords":["Research","gender","Autism","Brain","girls","boys"],"thumbnailUrl":"","author":[{"@type":"Person","name":"Alexandra Sifferlin","jobTitle":null,"url":"https://time.com/author/alexandra-sifferlin/"}],"articleSection":"Health","image":[],"publisher":{"@type":"Organization","name":"Time","url":"https://time.com/","logo":{"@type":"ImageObject","url":"https://time.com/images/logo.png","width":528,"height":156},"foundingDate":"March 3, 1923","sameAs":["https://www.facebook.com/time","https://www.instagram.com/time/?hl=en","https://twitter.com/time","https://www.pinterest.com/timemagazine"]}},{"@context":"https://schema.org","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"/section/health/","name":"Health"}},{"@type":"ListItem","position":2,"item":{"@id":"/tag/research/","name":"Research"}},{"@type":"ListItem","position":3,"item":{"@id":"https://time.com/3855645/autism-gender-differences/","name":"Why Autism Is Different in the Brains of Girls Than in Boys"}}]}] ```