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Hillary Clinton has been a national political figure since she came onto the scene in 1992. Through her varied career as First Lady, U.S. Senator from New York, Democratic presidential hopeful and Secretary of State, she has had her share of moments in the spotlight. As Clinton prepares to announce her second run for the White House, TIME magazine has collected some of the most interesting moments from her career, from interviews to speeches to press conferences and even testimony on Capitol Hill.

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