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A Socata TBM-900 (700N) at Glasgow airport in Scotland on March 14, 2014.
Iain Marshall

A New York real estate executive was piloting his his small plane from Rochester to Florida on Friday when he stopped communicating with air traffic controllers before eventually crashing near Jamaica.

Larry Glazer, who frequently flew that route, was traveling with his wife. FAA officials said the private plane had reached an altitude of 25,000 feet, prompting some officials to speculate he may have suffered from something known as hypoxia, in which parts of the brain are deprived of adequate oxygen.

It’s far too early to know for sure. But at that altitude, oxygen is so thin that brain cells can only survive for several minutes before they start dying off. Without enough oxygen, people become inattentive, show poor judgment and eventually stop breathing. With extended exposure at high altitudes, the brain shuts off and slips into a coma. Military pilots dispatched to track the aircraft after it failed to respond to air traffic control signals reported seeing the pilot slumped over.

The FAA has warned non-commercial pilots of the dangers of high altitude changes and hypoxia—in its first phases, the pilot won’t necessarily be aware that he’s experiencing oxygen deprivation. On the FAA site’s training section, a member of the agency’s education team urges more physiology training of pilots so they are aware and prepared for the dangers of hypoxia.

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