--- title: Cholesterol Risk Factor: Your Microbiome description: You may soon be adding your gut bugs to the list of things that can mess with your cholesterol levels canonical: https://time.com/4030145/bacteria-microbiome-cholesterol-levels/ author: Alice Park article:opinion: false article:content_tier: free article:published_time: 2015-09-10T21:47:34.000Z article:modified_time: 2026-08-04T07:57:51.663Z article:section: Health og:title: How Bacteria Control Your Cholesterol Levels og:description: You may soon be adding your gut bugs to the list of things that can mess with your cholesterol levels og:url: https://time.com/4030145/bacteria-microbiome-cholesterol-levels/ og:site_name: TIME og:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt47b2049e8a42d3f5/6988632e0b72e32b866e5c5d/cholesterol-test.jpg?branch=production&width=1200&quality=75&auto=webp&crop=16:9 og:image:width: 3000 og:image:height: 1688 og:image:alt: cholesterol test og:type: article twitter:card: summary_large_image twitter:title: How Bacteria Control Your Cholesterol Levels twitter:description: You may soon be adding your gut bugs to the list of things that can mess with your cholesterol levels twitter:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt47b2049e8a42d3f5/6988632e0b72e32b866e5c5d/cholesterol-test.jpg?branch=production&width=1200&quality=75&auto=webp&crop=16:9 ---  # How Bacteria Control Your Cholesterol > Sponsored content. 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Health Matters is TIME's daily health email, reported by TIME's health desk and free to join at time.com/newsletters. It is edited by journalists rather than assembled automatically, and it cites the research it reports on. #### Is Health Matters free? Yes. Health Matters is a free daily newsletter from TIME, available at time.com/newsletters. #### Who reads TIME's Health Matters newsletter? Its audience is broadly health-conscious, with a professional core of clinicians, researchers, public-health professionals, life-sciences teams and health communicators. ## Video: Half Of DNA, Bacteria In NYC Subways Are Unknown [Watch (HLS stream): Half Of DNA, Bacteria In NYC Subways Are Unknown](https://cdn.jwplayer.com/manifests/Ah09EAQf.m3u8) (1:51)  _Published 2015-02-06. Germaphobes, you’ve been warned. While Cornell researchers made some truly astounding findings when they did city-wide mapping of DNA and other microorganisms on subway surfaces, many of the microbes are there for our good._  by [Alice Park](https://time.com/author/alice-park/)  ## Alice Park Senior Correspondent Sep 10, 2015 9:47 PM UTC  A man's finger is pricked to test his cholesterol at the City of Newark's free homeless health fair at the Department of Child and Family Well-Being on Aug. 13, 2009 in Newark, N.J. A man's finger is pricked to test his cholesterol at the City of Newark's free homeless health fair at the Department of Child and Family Well-Being on Aug. 13, 2009 in Newark, N.J. Rick Gershon—Getty Images  by [Alice Park](https://time.com/author/alice-park/)  ## Alice Park Senior Correspondent Sep 10, 2015 9:47 PM UTC We don’t like to think about them, but we have trillions of bacteria living inside and on us. They’re not the disease-causing kind, but these microbes, primarily those that reside in our gut, help us digest food, keep the bad bugs at bay and, it turns out, have a lot to do with our metabolism. In a study published in the journal _Circulation Research_, scientists led by Jingyuan Fu from the University Medical Center Groningen in the Netherlands, and her colleagues quantify for the first time exactly how much the microbes in the gut contribute to blood cholesterol levels. Previous studies showed that the makeup of bacteria in the gut can influence obesity and heart disease, but it wasn’t clear by how much. **MORE:** [Premature Births Linked to Certain Bacteria](http://time.com/4000251/premature-births-bacteria/) Studying 893 people who provided fecal and blood samples, Fu and her team genetically sequenced the microbial material to get a better sense for which bacterial populations occupied the gut. They found 34 unique bacterial sequences that were linked to body mass index (BMI, a measure of height and weight) and blood lipid levels. Then they calculated how much variation in these groups of bacteria affected BMI and lipid levels. After accounting for age, gender and genetics, they concluded that the gut microbes accounted for 4.5% to 6% of the differences among the participants in triglyceride and HDL levels. Triglycerides are linked to higher risk of diabetes and heart disease, while HDL is connected with lower risk of these problems. When they included the microbiome, along with age, gender and genetics in looking at BMI and lipids, the combined contribution explain 26% of the differences in HDL (without the microbial information, the other factors explained about 19% to 20% of the variation among people). **MORE:** [A Strange New Way to Solve Crimes](http://time.com/4004400/a-strange-new-way-to-solve-crimes/) Having hard numbers to understand how much gut microbes might be contributing to metabolism, and therefore to the risk of chronic conditions such as heart disease, diabetes and obesity, may create a new ways of treating them. “We can intervene with bacterial populations in the future,” says Fu, “because the microbiome can be targeted for treatment with probiotics or medicine.” Before that can happen, however, she says that more studies to better understand what function the various bacteria have will be needed. So far, less than 30% of bacteria can be cultured outside of the body, which makes studying them more challenging, but researchers are working on ways to improve that. Once that happens, then scientists can manipulate the bacteria and study them in mouse populations to pinpoint which bugs contribute most directly to things such as HDL and BMI, and how to manipulate them to promote healthier levels. ```json [{"@context":"https://schema.org","@type":"NewsArticle","@id":"https://time.com/4030145/bacteria-microbiome-cholesterol-levels/","mainEntityOfPage":{"@type":"WebPage","@id":"https://time.com/4030145/bacteria-microbiome-cholesterol-levels/"},"headline":"How Bacteria Control Your Cholesterol","datePublished":"2015-09-10T21:47:34.000Z","dateModified":"2026-08-04T07:57:51.663Z","description":"You may soon be adding your gut bugs to the list of things that can mess with your cholesterol levels","url":"https://time.com/4030145/bacteria-microbiome-cholesterol-levels/","keywords":["Heart Disease","Bacteria","cholesterol","microbiome"],"thumbnailUrl":"https://static.time.com/v3/assets/bltea6093859af6183b/blt47b2049e8a42d3f5/6988632e0b72e32b866e5c5d/cholesterol-test.jpg?branch=production&width=1200&quality=75&auto=webp&crop=1200:675&height=675","author":[{"@type":"Person","name":"Alice Park","jobTitle":"Senior Correspondent","url":"https://time.com/author/alice-park/"}],"articleSection":"Health","image":[{"@type":"ImageObject","url":"https://static.time.com/v3/assets/bltea6093859af6183b/blt47b2049e8a42d3f5/6988632e0b72e32b866e5c5d/cholesterol-test.jpg?branch=production&width=1200&quality=75&auto=webp&crop=1200:675&height=675","width":1200,"height":675,"headline":"cholesterol test","caption":"cholesterol test","creditText":"Rick Gershon—Getty Images","representativeOfPage":true}],"publisher":{"@type":"Organization","name":"Time","url":"https://time.com/","logo":{"@type":"ImageObject","url":"https://time.com/images/logo.png","width":528,"height":156},"foundingDate":"March 3, 1923","sameAs":["https://www.facebook.com/time","https://www.instagram.com/time/?hl=en","https://twitter.com/time","https://www.pinterest.com/timemagazine"]}},{"@context":"https://schema.org","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"/section/health/","name":"Health"}},{"@type":"ListItem","position":2,"item":{"@id":"/tag/heart-disease/","name":"Heart Disease"}},{"@type":"ListItem","position":3,"item":{"@id":"https://time.com/4030145/bacteria-microbiome-cholesterol-levels/","name":"How Bacteria Control Your Cholesterol"}}]},{"@context":"https://schema.org","@type":"VideoObject","name":"Half Of DNA, Bacteria In NYC Subways Are Unknown","description":"Germaphobes, you’ve been warned. 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