--- title: Statins and Heart Disease: New Guidelines Lead to Fewer Heart Events description: A recent shift in how doctors figure out heart disease risk may lead to 63,000 fewer heart-related health problems canonical: https://time.com/3956485/heart-disease-statins/ author: Alice Park article:opinion: false article:content_tier: free article:published_time: 2015-07-14T15:00:10.000Z article:modified_time: 2026-08-04T08:05:06.179Z article:section: Health og:title: Changes in Statin Use Are Leading to Less Heart Disease og:description: A recent shift in how doctors figure out heart disease risk may lead to 63,000 fewer heart-related health problems og:url: https://time.com/3956485/heart-disease-statins/ og:site_name: TIME og:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt52c2513617708c9b/69885ab98e0601c4eb4615f0/gettyimages-128585544.jpg?branch=production&width=3840&quality=75&auto=webp&crop=16:9 og:image:width: 1200 og:image:height: 675 og:image:alt: 128585544 og:type: article twitter:card: summary_large_image twitter:title: Changes in Statin Use Are Leading to Less Heart Disease twitter:description: A recent shift in how doctors figure out heart disease risk may lead to 63,000 fewer heart-related health problems twitter:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt52c2513617708c9b/69885ab98e0601c4eb4615f0/gettyimages-128585544.jpg?branch=production&width=3840&quality=75&auto=webp&crop=16:9 ---  # New Advice on Statins Is Leading to Less Heart Disease ## Video: FDA Trans Fat Ban Could Hurt Those Who Didn't Heed Warnings [Watch (HLS stream): FDA Trans Fat Ban Could Hurt Those Who Didn't Heed Warnings](https://cdn.jwplayer.com/manifests/b2180nL7.m3u8) (1:06)  _Published 2015-06-16. On Tuesday morning, the FDA ruled U.S. food producers must phase out the main source of trans fats within three years._  by [Alice Park](https://time.com/author/alice-park/)  ## Alice Park Senior Correspondent Jul 14, 2015 3:00 PM UTC  Lipitor (Atorvastatin calcium) is a synthetic lipid-lowering agent created to reduce elevated blood cholesterol levels when accompanied with diet changes. Lowering blood levels of fat and cholesterol can help reduce the risk of heart disease, strokes, ang Lipitor (Atorvastatin calcium) is a synthetic lipid-lowering agent created to reduce elevated blood cholesterol levels when accompanied with diet changes. Lowering blood levels of fat and cholesterol can help reduce the risk of heart disease, strokes, angGetty Images  by [Alice Park](https://time.com/author/alice-park/)  ## Alice Park Senior Correspondent Jul 14, 2015 3:00 PM UTC In 2013, when the American Heart Association and the American College of Cardiology [revised the guidelines that doctors use to decide which patients need cholesterol-lowering treatment](http://healthland.time.com/2013/11/12/new-guidelines-for-cholesterol-treatments-represent-huge-change/) for heart disease and which do not, there was more confusion than confidence in the new advice. Now, a new [study published in _JAMA_](http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.2015.7515) may offer some answers about the effects of the updated treatment guidelines. Rather than setting threshold levels of target cholesterol levels that were considered normal or high, for example, the new guidelines instead assessed a person’s overall risk of having a heart attack, stroke or other heart problem over the next 10 years. If these factors—which included cholesterol, family history of heart disease, age and other factors—contributed to a risk of 7.5% or higher, then the person would be eligible for taking the cholesterol-lowering drugs known as statins, which not only bring potentially troublesome fat levels in the blood down but also reduce inflammation, which can contribute to atherosclerosis and set the stage for a heart attack. **MORE:** [Should I Take a Statin? What You Need to Know About the New Cholesterol Guidelines](http://healthland.time.com/2013/11/20/should-i-take-a-statin-what-you-need-to-know-about-the-new-cholesterol-guidelines/) Heart experts weren’t all convinced that putting more people on statins would actually lead to fewer heart events. Their biggest concern was that the looser criteria would mean more otherwise healthy people who wouldn’t really benefit from statins would be taking the drugs. (Some estimates showed that [as many as 12.8 million more people](http://time.com/30880/new-cholesterol-guidelines-may-put-13-million-more-on-statin-drugs/) would be taking the medications under the new guidelines.). So Dr. Udo Hoffman, director of the cardiac MR, PET and CT Program at Massachusetts General Hospital and his colleagues decided to analyze the data to see if the new guidelines really were contributing to less heart disease. In the new study, they compared 2,435 people who were the offspring or third generation descendants of the Framingham Heart Study, the pioneering heart disease trial that continues to follow people and track their lifestyle and health outcomes. Some of the participants in the current study were at higher risk of heart disease, and some were not. Using the older cholesterol-based heart risk guidelines, Hoffman found that 14% would have been given a statin. Nearly three times that proportion, 39%, would have qualified under the new 2013 guidelines. **MORE:** [New Guidelines for Cholesterol Treatments Represent “Huge Change”](http://healthland.time.com/2013/11/12/new-guidelines-for-cholesterol-treatments-represent-huge-change/) When the researchers looked at how many of those people who were eligible to take statins went on to have heart events, it was more than twice as high using the newer guidelines. That means that a higher proportion of people who should be on statins, according to the newer guidelines, went on to have heart events, suggesting that the new criteria were better at predicting which people were at higher risk. In addition, Hoffman also backed up his findings with tests of the amount of calcium in the heart vessels of the participants. Coronary artery calcium tends to be a good indicator of how stiff the vessels are becoming; more calcium suggests more atherosclerosis and therefore a higher risk of heart attack or other issues. **MORE:** [Statins May Seriously Increase Diabetes Risk](http://time.com/3732605/statins-may-seriously-increase-diabetes-risk/) The findings were especially robust in those people considered to be at intermediate risk of heart disease—patients in the grey area where it’s not entirely clear how likely they are to have heart problems. Among them, those who qualified to take statins under the newer 2013 guidelines were nine times more likely to have a heart event than those who didn’t meet the criteria for needing the drugs. “If we looked at this group from the formal risk factor evaluation approach \[using the older guidelines\] there is no way we could guess which of these people were at higher risk of heart events,” says Hoffman. “So in this population, the new guidelines are helpful.” The findings show that even if the revised guidelines cast a wider net of people who would be on statin drugs, the rate of heart events the new criteria are picking up remain about the same. That means that the people being captured are still those at higher risk of having events, and not healthy people who would be unnecessarily put on medications, as some critics of the new guidelines feared. “Overall, the new guidelines are a more accurate and efficient allocation of statin therapy,” says Hoffman. Statins and Heart Disease: New Guidelines Lead to Fewer Heart Events ```json [{"@context":"https://schema.org","@type":"NewsArticle","@id":"https://time.com/3956485/heart-disease-statins/","mainEntityOfPage":{"@type":"WebPage","@id":"https://time.com/3956485/heart-disease-statins/"},"headline":"New Advice on Statins Is Leading to Less Heart Disease","datePublished":"2015-07-14T15:00:10.000Z","dateModified":"2026-08-04T08:05:06.179Z","description":"A recent shift in how doctors figure out heart disease risk may lead to 63,000 fewer heart-related health problems, a new study shows","url":"https://time.com/3956485/heart-disease-statins/","keywords":["Heart Disease","statins","cholesterol"],"thumbnailUrl":"https://static.time.com/v3/assets/bltea6093859af6183b/blt52c2513617708c9b/69885ab98e0601c4eb4615f0/gettyimages-128585544.jpg?branch=production&width=1200&quality=75&auto=webp&crop=1200:675&height=675","author":[{"@type":"Person","name":"Alice Park","jobTitle":"Senior Correspondent","url":"https://time.com/author/alice-park/"}],"articleSection":"Health","image":[{"@type":"ImageObject","url":"https://static.time.com/v3/assets/bltea6093859af6183b/blt52c2513617708c9b/69885ab98e0601c4eb4615f0/gettyimages-128585544.jpg?branch=production&width=1200&quality=75&auto=webp&crop=1200:675&height=675","width":1200,"height":675,"headline":"128585544","caption":"128585544","creditText":"Getty Images","representativeOfPage":true}],"publisher":{"@type":"Organization","name":"Time","url":"https://time.com/","logo":{"@type":"ImageObject","url":"https://time.com/images/logo.png","width":528,"height":156},"foundingDate":"March 3, 1923","sameAs":["https://www.facebook.com/time","https://www.instagram.com/time/?hl=en","https://twitter.com/time","https://www.pinterest.com/timemagazine"]}},{"@context":"https://schema.org","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"/section/health/","name":"Health"}},{"@type":"ListItem","position":2,"item":{"@id":"/tag/heart-disease/","name":"Heart Disease"}},{"@type":"ListItem","position":3,"item":{"@id":"https://time.com/3956485/heart-disease-statins/","name":"New Advice on Statins Is Leading to Less Heart Disease"}}]},{"@context":"https://schema.org","@type":"VideoObject","name":"FDA Trans Fat Ban Could Hurt Those Who Didn't Heed Warnings","description":"On Tuesday morning, the FDA ruled U.S. food producers must phase out the main source of trans fats within three years.","thumbnailUrl":"https://cdn.jwplayer.com/v2/media/b2180nL7/poster.jpg?width=720","uploadDate":"2015-06-16T15:07:18.000Z","contentUrl":"https://cdn.jwplayer.com/manifests/b2180nL7.m3u8","embedUrl":"https://time.com/3956485/heart-disease-statins/","duration":"PT1M6S","potentialAction":{"@type":"SeekToAction","target":"https://time.com/3956485/heart-disease-statins/?jw_start={seek_to_second_number}","startOffset-input":"required name=seek_to_second_number"}}] ```