--- description: Between 1954 and 1955, the polio vaccine transitioned from a trial of 1.8 million to a reality for households across America. title: From Polio Vaccine Trials to Mass Production in One Year image: https://static.time.com/v3/assets/bltea6093859af6183b/blt5a9e537186ef0023/6987ea588e0601bf2e45e0ac/150409-polio-vaccine-10.jpg?branch=production&width=3840&quality=75&auto=webp&crop=16:9 ---  * [medicine](/tag/medicine/) ## medicine Update your preferences in [Account Settings](/account/preferences/) Close # How the Polio Vaccine Trials Relieved a Worried Nation  by [Eliza Berman](/author/eliza-berman/)  ## Eliza Berman Update your preferences in [Account Settings](/account/preferences/) Close Berman is a senior editor at TIME. Apr 24, 2015 2:00 PM CUT  Child receiving a polio vaccination, 1955. Child receiving a polio vaccination, 1955.Al Fenn—The LIFE Picture Collection/Getty Images  by [Eliza Berman](/author/eliza-berman/)  ## Eliza Berman Update your preferences in [Account Settings](/account/preferences/) Close Berman is a senior editor at TIME. Apr 24, 2015 2:00 PM CUT  Dr. Jonas Salk examining test tube sample of polio virus used in making his polio vaccine, at Univ. of Pittsburgh. Alfred Eisenstaedt—The LIFE Picture Collection/Getty Images On April 26, 1954, children at the Franklin Sherman Elementary School in McLean, Virginia, held their breaths as needles penetrated the skin of their upper arms. They were the first of nearly two million volunteers in a three-month trial of epidemiologist Jonas Salk’s inactivated polio vaccine, which would be deemed safe for general use just shy of one year later. The day before the trials were deemed a success, in April 1955, LIFE published a series of photos of a nation preparing for wide distribution of the vaccine it desperately hoped would be approved. The National Polio Foundation had 27 million vaccine shots ready for release, to be administered to all first- and second-grade students and children who had received a placebo during the 1954 trial. Pharmaceutical companies, too, had chosen not to wait for the announcement to begin their own frantic manufacturing process. During the early 1950s, polio cases in the U.S. had surged to nearly 60,000, with around one third rendering victims paralyzed. Given parents’ heightened fear for their children’s health in recent years, it didn’t take long for Salk to be hailed a hero: --- > “” --- In the years since the vaccine’s development, polio has been all but eradicated throughout most of the world, save for a few countries where vaccination is not universally available and prevention continues to be a struggle. _Liz Ronk, who edited this gallery, is the Photo Editor for LIFE.com. Follow her on Twitter at_ [_@LizabethRonk_](https://twitter.com/LizabethRonk "undefined")_._  Caption from LIFE. Working under glass for extra safety, technician begins vaccine process with kidney tissue. Al Fenn—The LIFE Picture Collection/Getty Images  Polio vaccine production, 1955. Al Fenn—The LIFE Picture Collection/Getty Images  Polio vaccine production, 1955. Al Fenn—The LIFE Picture Collection/Getty Images  Polio vaccine production, 1955. Al Fenn—The LIFE Picture Collection/Getty Images  Caption from LIFE. In incubator room, test tubes of vaccine samples rotate slowly in drums for seven days under controlled temperature. The samples are then analyzed. Al Fenn—The LIFE Picture Collection/Getty Images  Caption from LIFE. To kill virus, worker makes up formaldehyde solution which is pumped into tube overhead simultaneously with vaccine-to-be from tank. When throughly mixed, liquid goes back into tank where formaldehyde does its work. Al Fenn—The LIFE Picture Collection/Getty Images  Caption from LIFE. Potency test is performed with monkey who gets injections of vaccine just as children. Blood sample is examined to see if antibodies have formed. Al Fenn—The LIFE Picture Collection/Getty Images  Polio vaccine production, 1955. Al Fenn—The LIFE Picture Collection/Getty Images  Polio vaccine production, 1955. Al Fenn—The LIFE Picture Collection/Getty Images  Child receiving a polio vaccination, 1955. Al Fenn—The LIFE Picture Collection/Getty Images ```json [{"@context":"https://schema.org","@type":"NewsArticle","@id":"https://time.com/3815680/polio/","mainEntityOfPage":{"@type":"WebPage","@id":"https://time.com/3815680/polio/"},"headline":"How the Polio Vaccine Trials Relieved a Worried Nation","datePublished":"2015-04-24T14:00:38.000Z","dateModified":"2026-05-11T05:04:37.146Z","description":"Between 1954 and 1955, the polio vaccine transitioned from a trial of 1.8 million to a regular feature of life for households across America","url":"https://time.com/3815680/polio/","keywords":["medicine","photography","polio","LIFE Magazine","1955"],"thumbnailUrl":"https://static.time.com/v3/assets/bltea6093859af6183b/blt5a9e537186ef0023/6987ea588e0601bf2e45e0ac/150409-polio-vaccine-10.jpg?branch=production&width=1200&quality=75&auto=webp&crop=1200:675&height=675","author":[{"@type":"Person","name":"Eliza Berman","jobTitle":"Berman is a senior editor at TIME.","url":"https://time.com/author/eliza-berman/"}],"articleSection":"","image":[{"@type":"ImageObject","url":"https://static.time.com/v3/assets/bltea6093859af6183b/blt5a9e537186ef0023/6987ea588e0601bf2e45e0ac/150409-polio-vaccine-10.jpg?branch=production&width=1200&quality=75&auto=webp&crop=1200:675&height=675","width":1200,"height":675,"headline":"Polio vaccine production, 1955","caption":"Child receiving a polio vaccination, 1955.","creditText":"Al Fenn—The LIFE Picture Collection/Getty Images","representativeOfPage":true}],"publisher":{"@type":"Organization","name":"Time","url":"https://time.com/","logo":{"@type":"ImageObject","url":"https://time.com/images/logo.png","width":528,"height":156},"foundingDate":"March 3, 1923","sameAs":["https://www.facebook.com/time","https://www.instagram.com/time/?hl=en","https://twitter.com/time","https://www.pinterest.com/timemagazine"]}},{"@context":"https://schema.org","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"/tag/medicine/","name":"medicine"}},{"@type":"ListItem","position":2,"item":{"@id":"https://time.com/3815680/polio/","name":"How the Polio Vaccine Trials Relieved a Worried Nation"}}]}] ```