--- title: Charlotte's Web: Medical Marijuana Epilepsy Study Beginning description: A groundbreaking clinical trial may provide some answers to medical marijuana as a seizure treatment canonical: https://time.com/3264691/medical-marijauna-epilepsy-research-charlottes-web-study/ author: Kate Pickert article:opinion: false article:content_tier: free article:published_time: 2014-09-03T19:36:15.000Z article:modified_time: 2026-08-04T08:00:45.847Z article:section: Health og:title: Finally, Some Hard Science on Medical Marijuana for Epilepsy Patients og:description: A new study will test the link between a marijuana strain and seizure treatment og:url: https://time.com/3264691/medical-marijauna-epilepsy-research-charlottes-web-study/ og:site_name: TIME og:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt7efdf62eb0015073/6986a1d93bc99944441a5251/charlotte-figi-marijuana.jpg?branch=production&width=1200&quality=75&auto=webp&crop=16:9 og:image:width: 5760 og:image:height: 3240 og:image:alt: Matt Figi, Charlotte Figi og:type: article twitter:card: summary_large_image twitter:title: Finally, Some Hard Science on Medical Marijuana for Epilepsy Patients twitter:description: A new study will test the link between a marijuana strain and seizure treatment twitter:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt7efdf62eb0015073/6986a1d93bc99944441a5251/charlotte-figi-marijuana.jpg?branch=production&width=1200&quality=75&auto=webp&crop=16:9 ---  # Finally, Some Hard Science on Medical Marijuana for Epilepsy Patients > Sponsored content. 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Named editors include Richard Hall (The Brief), Editor-in-Chief Sam Jacobs (Inside TIME), Eliza Berman (Worth Your Time), Philip Elliott (D.C. Brief), Justin Worland (Future Proof) and Harry Booth (In the Loop). Health Matters is written by TIME's health desk. #### How do I sign up for a TIME newsletter? Go to time.com/newsletters, choose the newsletters you want and enter your email address. There is no cost and no subscription requirement. ### Sources * TIME Newsletters: [time.com/newsletters](/c/time-nl-network-2026q3/newsletters?i=c92e892f-1164-4cd4-8ca3-a925f6fab112&cr=time-nl-network-2026q3-v1) ## Video: Colorado Sets Rules For Pot Edibles [Watch (HLS stream): Colorado Sets Rules For Pot Edibles](https://cdn.jwplayer.com/manifests/s9DsgdzE.m3u8) (1:30)  _Published 2014-08-01. Colorado officials are tightening the rules and regulations for pot edibles to make accidental overdoses more difficult. Regulators drafted an emergency rule making it easier for consumers to tell how much THC is in the edibles they’re consuming._ by [Kate Pickert](https://time.com/author/kate-pickert/) ## Kate Pickert Sep 3, 2014 7:36 PM UTC  Matt Figi hugs his 7-year-old daughter Charlotte inside a Colorado greenhouse. The plants are a special strain of medical marijuana known as Charlotte's Web, which was named for Charlotte after she used the plant to treat epileptic seizures Matt Figi hugs his 7-year-old daughter Charlotte inside a Colorado greenhouse. The plants are a special strain of medical marijuana known as Charlotte's Web, which was named for Charlotte after she used the plant to treat epileptic seizures Brennan Linsley—AP by [Kate Pickert](https://time.com/author/kate-pickert/) ## Kate Pickert Sep 3, 2014 7:36 PM UTC _Correction appended, Sept. 5, 2014_ For years, some parents have turned to medical marijuana to treat their children’s debilitating epilepsy, crediting the drug with dramatically reducing seizure activity. A groundbreaking clinical trial about to begin recruiting test subjects may finally provide some science to back their claims. In what is believed to be the first study of its kind, researchers at the University of Colorado Anschutz Medical Campus will [study](http://clinicaltrials.gov/ct2/show/NCT02229032?term=Dravet&rank=1) the genes of those with a kind of epilepsy called Dravet Syndrome who have been treated with a strain of medical marijuana known as [Charlotte’s Web](http://cwbotanicals.com/). The study will attempt to determine if specific genetic components can explain why some epilepsy patients see positive results from ingesting Charlotte’s Web, while others do not. The plant, grown by five brothers in Colorado through a non-profit organization called [Realm of Caring](http://www.theroc.us/), is low in THC, the compound that produces marijuana’s psychoactive effects, and high in CBD, a compound believed to reduce seizures in those suffering from certain forms of epilepsy. It is administered to epilepsy patients, including many children, in the form of an oil. The plant is named after Charlotte Figi, a young girl who was the first epilepsy patient successfully treated with the strain. While anecdotal evidence suggests Charlotte’s Web can be highly effective in treating such conditions, scientific investigation of the product has been stymied by federal drug laws that severely limit marijuana research. Edward Maa, the principal investigator of the Charlotte’s Web study, says the new trial could be a first step toward building a body of research on how and why medical marijuana can be used to treat epilepsy. “This is the first attempt to get the information people are interested in that is observational in nature,” says Maa, an assistant professor at the CU School of Medicine and chief of the Comprehensive Epilepsy Programs at Denver Health. The new study will recruit epilepsy patients who have already taken Charlotte’s Web. The patients will be divided into two groups—those who have seen seizure activity reduced by at least 50 percent on Charlotte’s Web and those who have had less dramatic or no results from taking the marijuana oil. Genetic analysis of the patients in both groups will then be performed in hopes of discovering what genetic components may cause a patient to be responsive to medical marijuana. Interventional studies, in which patients would be given Charlotte’s Web to measure its efficacy, are far more difficult to conduct. “That would be the Holy Grail,” says Maa. Still, researchers on the CU Anschutz team will collect data on dosages used by patients in the study, for example, which could allow for further research down the line. “The more data we are able to collect in a large sample, the closer to the truth we will get,” says Maa. He says the study could allow children with Dravet Syndrome to be genetically screened before taking Charlotte’s Web so parents could know ahead of time if their children would benefit. It’s possible to conduct the study in Colorado because Charlotte’s Web is grown there legally and is home to many families who have moved to the state to specifically to access the marijuana strain. “Do you uproot and move your entire family to not have an effect? I think this could be very helpful to answer this question,” says Maa. Recruiting for the new study will begin within a month and data will be collected until February 2016. Correction: The original version of this story misstated the location where a study on medical marijuana will take place. It is the University of Colorado Anshutz Medical Campus. ## Transcript [00:00] Colorado officials are tightening the rules and [00:02] regulations of pot edibles to make accidental [00:05] overdoses more difficult. The state does recreational [00:08] edibles to contain up to 100 mg of THC, the active [00:12] ingredient in pot. The regulators are concerned about [00:15] overdoses and are also asking for more [00:18] child- resistant packaging. To address this concern, [00:20] regulators drafted an emergency rule Thursday that [00:23] makes it easier for consumers to tell how much THC is [00:27] in the edibles they are consuming. The result is weaker [00:30] edible marijuana products and new packaging [00:32] requirements. Consuming too much marijuana can [00:35] severely impair judgement and deadly consequences [00:37] have been noted in the past. Back in April, a Wyoming [00:40] college student ate a marijuana cookie and fell off a [00:43] hotel balcony to his death. Many marijuana edibles [00:46] have been sold in 100 milligram packages in the past, [00:49] but many experienced users say about half of that. Will [00:53] have a significant affect on them. Yeah I mean for me, [00:54] personally, like, to feel like pretty [00:59] high, like 50. For me, 50mg works. [01:03] So maybe try half the cookie? As the Denver Post [01:07] points out under the new regulations, marijuana [01:10] edibles can still contain up to 100mg of thc, but they [01:14] must be easily broken into pieces that contain 10mg or [01:17] less and be clearly marked with the amount. Similar [01:20] regulations with marijuana edibles have already been [01:23] enforced in Washington. 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