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The tough-as-nails Ripley was a breakout role for Weaver, who recently revisited the character for a new Alien video game.20TH CENTURY FOX
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Though Weaver's character, Dr. Grace Augustine, died at the end of 2009's Avatar, the actress will come back as a different character in the upcoming sequels.20th Century Fox
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In 1999's meta comedy Galaxy Quest, Weaver played actress Gwen DeMarco, who in turn played the not-so-bright Lt. Tawny Madison.Jerry Watson—Camera Press
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As Dana Barrett in the Ghostbusters movies, Weaver knew who to call when paranormal forces set their sights on her apartment.Columbia
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Weaver brought the true story of renowned primatologist Dian Fossey, who was mysteriously murdered in 1985, to the big screen in 1988's Gorillas in the Mist.Universal
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As Katharine Parker, Weaver was the nightmare boss to Melanie Griffith's Tess McGill in 1988's Working Girl.20th Century Fox
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You wouldn't want to cross Warden Walker, the cruel authority figure in 2003's Holes who made nail polish with rattlesnake venom.Buena Vista
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