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Terms and conditions apply. * Savings buckets are a feature of Ally Bank's Savings Account. * No ATM fees from Ally Bank at Allpoint and Moneypass ATMs plus we reimburse for fees charged by other ATM owners nationwide up to $10 per statement cycle. * Early direct deposit offers eligible direct deposits up to two days sooner. * Spending buckets are a feature of Ally Bank's Spending Account. ## Video: The Longevity Issue | Decoding the Ovary [Watch (HLS stream): The Longevity Issue | Decoding the Ovary](https://cdn.jwplayer.com/manifests/9JKK1QlE.m3u8) (0:55)  _Published 2026-01-13. Scientists are targeting the organ to try to slow down aging. Will it work?_ by [Dominique Mosbergen](https://time.com/author/dominique-mosbergen/) ## Dominique Mosbergen Health correspondent  Illustration by Joan Wong for Time Deena Emera was mesmerized by the images on the screen. “They were beautiful,” she says of the slides she saw in December—each a microscopic closeup of a bowhead whale’s ovary. The images were marvelously crisp and showed the mottled outer layer of the organs. Bowhead whales are considered the longest-living mammals on earth. They can live for more than 200 years, and females can reproduce well after their 100th birthdays. Emera, an evolutionary biologist, has long wondered: “What is different about their ovaries that allows them to continue ovulating for so long?” Could we harness those qualities to benefit human health? She had to find out. But obtaining samples of any kind from a bowhead whale is a Sisyphean challenge. The whales—giants of the ocean that can span 60 ft. in length and weigh 100 tons—are endangered, and only Indigenous subsistence whalers in Alaska, Canada, Greenland, and Russia are permitted to hunt them. Emera spent three years cultivating relationships with some of these whalers, working to persuade them of the value of her research. Even then, she didn’t know if it would even be possible to get usable samples. “Killing a bowhead whale is quite the process because it’s such a humongous animal,” says Emera, a senior scientist at the Buck Institute for Research on Aging in California. “It takes the whalers a long time to get the animal to shore, so it’s possible that the tissue I need is going to go bad.” During a hunt in August, a female bowhead was killed in [Arctic](https://time.com/7004330/arctic-us-russia-china/) waters. Her ovaries—hefty things, each measuring over a foot—were removed and samples were taken. Emera was finally able in early December to see slides of the tissue. She was nervous about what she might see. “Samples that are not fresh can look very mushy,” she says. To her relief, the images were sharp and appeared to be what she needed. The tissue will now undergo genetic sequencing. “Will it be good enough quality to get good data—and if it is, then what will we see?” she says. A study by other researchers published in October found that bowhead whales possess an exceptional ability to repair damaged DNA, which researchers think could explain their long lives and ability to stave off diseases of aging like [cancer](https://time.com/7334094/come-see-me-in-the-good-light-andrea-gibson/). “I suspect the mechanisms involved in bowhead longevity overlap with the mechanisms that enable them to reproduce for so long,” says Emera, who wrote a [book](https://www.deenaemera.com/) about the evolution of the female body. “What we learn from these animals could help humanity.” Emera is among a growing group of scientists who think that ovaries—which, when functioning optimally, appear to be a source of [vitality](https://time.com/7339382/nudge-words-to-adopt-this-year/#:~:text=Advertisement-,Vitality,-Many%20New%20Year%E2%80%99s)—could harbor secrets that could help us all live healthier for longer. --- [Ovaries](https://time.com/7284907/ovarian-cyst-diagnosis-treatment/) are ubiquitous in the animal kingdom. Most female vertebrates—mammals, birds, fish—have them, as do earthworms and beetles and squid. About half of all humans are born with them, but until very recently, scientists’ and doctors’ interest in ovaries has focused largely on their role as potential [baby-makers](https://time.com/7174932/merle-bombardieri-profile-baby-decision-book/) or victims of diseases like cancer. That interest, however, is rapidly expanding as researchers have started to uncover the key role that ovaries play in female health and [aging](https://time.com/collections/future-of-living/7341845/joyspan-kerry-burnight-longevity-old-age/). “The ovary can teach us a lot. You could even posit that it’s a fountain of youth,” says Diana Laird, a researcher at the University of California, San Francisco, who is studying how ovaries age. “Whatever the special sauce is could be an elixir for better health for women and men too.” Ovaries are the source of the eggs and hormones needed during pregnancy, but it turns out they do so much more than what we learned in high school biology class. “The ovaries are the control center of a really complex signaling network,” says Jennifer Garrison, a neuroscientist and former executive director of the [Productive Health Global Consortium](https://www.buckinstitute.org/gcrle/), an organization that funded ovarian health research. Through hormones and other chemicals, the ovaries are “talking to almost every tissue in the female body,” Garrison says. “Ovaries are like conductors in an orchestra. They’re coordinating things like bone health, [heart health](https://time.com/7316703/heart-health-at-every-decade/), and metabolism.” And when that coordination stops or becomes faulty, health problems can emerge. “It’s kind of like losing the wi-fi signal to half of your devices,” Garrison says. “I don’t want to make it sound like we understand how that works. We don’t. But we do know what happens when you either take ovaries away or when their function changes” as they age. Menopause, when a woman’s period ceases, is a stark example of the consequences of ovarian aging. It occurs when the ovaries stop releasing eggs and hormones such as estrogen and progesterone. Menopause is the inescapable counterpoint to menstruation; it happens at the average age of 51 in the U.S. After [menopause](https://time.com/collections/time-for-you-menopause/7339544/early-menopause-symptoms-what-to-know/), a woman’s risk for many age-related diseases, including cardiovascular disease, dementia, [osteoporosis](https://time.com/7160971/how-to-improve-bone-health/), and metabolic diseases, increases sharply. “Menopause is the worst thing that happens for women’s health because it’s literally the start of everything that’s going to go wrong in an accelerated manner,” says Bérénice Benayoun, an ovarian-aging researcher at the University of Southern California. Garrison says her [cholesterol](https://time.com/6209652/how-to-lower-your-cholesterol-naturally/) went through the roof during perimenopause, the transition period before menopause that is characterized by fluctuating hormone levels and symptoms such as hot flashes and [insomnia](https://time.com/7011068/insomnia-best-treatment-sleep-schedule/). “I now understand that my risk of heart disease skyrocketed,” says Garrison, who will soon turn 50\. Studies have shown that the earlier someone experiences menopause, the higher the risk of developing age-related diseases; conversely, the later the onset of menopause, the longer a woman is likely to live. (Preliminary data suggests that men with mothers or sisters who experience later menopause tend to live longer too.) Despite the health issues associated with [menopause](https://time.com/collections/time-for-you-menopause/7325508/menopause-symptoms/), options to treat them are limited. The most common treatment is [menopausal hormone therapy](https://time.com/7332940/fda-estrogen-menopause-black-box-warning/), which has been used since the 1940s and is approved by the U.S. Food and Drug Administration to treat symptoms like hot flashes and to prevent osteoporosis. Studies have found that women who start hormone therapy within 10 years of menopause onset have a reduced risk of death from all causes. Some critics, however, say more research still needs to be done to confirm the drugs are safe. Even women’s-health experts who support the use of hormone therapy say more robust and updated studies are needed. Hormone therapy remains the “best Band-Aid we have” to mitigate menopause-related health risks, says Garrison, yet “there has been almost zero innovation in 80 years.” A novel treatment targeting the ovaries could be groundbreaking. --- Women live longer, on average, than men. But women tend to be sicker than men as they grow older, suffering from more chronic diseases and disability. Scientists don’t know for sure if loss of ovarian function is driving this diminished resilience or if something else is going on that is hastening aging in women and causing the ovaries to fail. But what seems clear is that as ovaries age and their function declines—which some scientists think may start to happen 10 to 15 years before menopause—a woman’s overall health takes a dive too. In cases where a woman’s ovaries need to be removed entirely, her risk for chronic conditions including cardiovascular disease surpasses that of a post-menopausal woman, suggesting that even after the ovaries stop releasing [eggs](https://time.com/7285337/grief-discarding-frozen-eggs/), they still play a role in preserving overall health. By unraveling how ovaries function, scientists hope to better understand how they might promote health and also find ways to slow their aging. Doing that could potentially extend women’s health spans—the number of years they spend in good health—and allow women to have children later if they so choose. Women suffering from other conditions linked to ovarian dysfunction, such as infertility and polycystic ovary syndrome ([PCOS](https://time.com/3065882/diseases-doctors-get-wrong/)), could also benefit, as could girls and women whose ovarian function becomes impaired before 40—a condition known as primary ovarian insufficiency, which can be triggered by disease or treatments like chemotherapy. The ovaries, scientists have found, are among the fastest-aging organs in the human body. “You don’t call a 40-year-old brain an aging brain, but for 40-year-old ovaries, they are already in the nursing home,” says Yousin Suh, a reproductive-sciences professor at Columbia University. To understand why, Suh compared ovaries from women in their 20s and late 40s. “I thought that maybe I would find some secret, something specific that was causing this rapid aging,” Suh says. “But what I found blew my mind.” The ovaries, she discovered, were aging exactly like all the other organs in the body—just at a much faster rate. “There was nothing special,” she says. “It was the same mechanisms of aging that you see in other parts of the body: telomere shortening, mitochondrial dysfunction, cellular senescence, stem-cell exhaustion. But happening in this much more compressed way. We had never seen anything like it.” The discovery suggested something tantalizing: that the ovaries could offer a preview of how the entire body will age. Since the ovaries age in such a rapid way, they could also be used to more efficiently test anti-aging treatments. “It gave me hope that, my God, now we can really do intervention studies,” says Suh, whose lab is leading a pilot study on whether [rapamycin](https://time.com/7264207/can-you-delay-menopause/), a drug that has in other experiments extended the life of animals, could slow ovarian aging in people. Experiments conducted at Northwestern University have found that drugs similar to rapamycin can boost fertility in mice, including during chemotherapy, says Dr. Kara Goldman, a reproductive endocrinologist who is leading the research. The drugs, if proven to work in people, could be used to help women struggling with infertility, as well as those undergoing cancer treatments, she says. --- Piraye Yurttas Beim wants to make menopause optional. “I have a daughter who’s 8, and I want her generation to be mind-blown that menopause was a thing,” says Beim, founder of [Celmatix Therapeutics](https://www.celmatix.com/), a biotech company that is exploring whether a hormone known as AMH, or anti-Müllerian hormone, could delay menopause and improve fertility. The hormone has been shown in mice to protect ovarian function from accelerated aging caused by chemotherapy. Beim says it was a dinner conversation in 2019 that cemented her conviction in this mission. Beim, then in her early 40s, had been discussing [perimenopause](https://time.com/7019600/perimenopause-signs-symptoms/) with her then husband. “‘Buckle up,’ I told him. ‘It’s like puberty, but all over again in mid-life,’” she remembers saying. “He responded, ‘Isn’t there anything we can do about this?’” “That was the light-bulb moment for me,” says Beim, a molecular biologist who had started Celmatix a decade earlier to develop drugs that target ovarian health and treat women’s reproductive conditions such as infertility and endometriosis, which she suffers from. “I asked myself, Why should anybody experience a decline in their ovarian function?” Beim started to dig into the history of women’s health and what she calls the “normalization” of menopause, and she became increasingly indignant. “There’s nothing normal about it. Menopause is just as ‘normal’ and ‘natural’ as having tooth decay, osteoarthritis, heart disease, cancer,” she says. David Pepin, a researcher at Mass General and Harvard, discovered in 2017 that AMH is effective at stopping the growth of ovarian follicles. Follicles are the functional units of the ovary: they produce essential hormones and are the “house” in which an egg develops. At any given time before menopause, multiple follicles are being awakened from a dormant state and are starting to grow. The vast majority of them, however, will degenerate and die. During a typical menstrual cycle, one egg usually matures and is released for possible fertilization. “But you lose the rest of the growing follicles. It’s a very destructive process,” says Pepin. At birth, ovaries come with all the follicles they will ever have—about a million. After about 30 years, typically about 100,000 follicles remain. The speed of follicle death increases with age, and by the time menopause hits, the average woman has fewer than a thousand. AMH is produced by the ovaries, and one of its primary functions is controlling the number of follicles that are awakened to start growing. Pepin found that AMH can stop follicles from waking up and therefore limit the number of them that are lost. A company he co-founded called [Oviva Therapeutics](https://www.ovivatx.com/)—which Granata Bio acquired in 2025—is developing an AMH drug that it hopes could improve fertility and ovarian function. Pepin’s lab has been experimenting with AMH in mice to see if the hormone can preserve fertility in chemotherapy patients. Pepin says he doesn’t think the hormone could delay menopause indefinitely, but it might be able to keep the ovaries functional for longer and mitigate menopausal symptoms. Celmatix is experimenting with a drug that closely mimics AMH, Beim says. They will soon test the molecule in primates before starting trials in people. --- Elsewhere, scientists enthralled by the ovary are going back to basics. The data we have on [women’s health](https://time.com/collections/time100-leadership-forums-2025/7314683/womens-health-bridging-gaps/) is generally abysmal—and our knowledge of the ovaries is even worse. Only in recent years did scientists discover the presence in the ovaries of glia, usually thought of as support cells for neurons in the brain and nervous system. (Researchers don’t yet know what they’re doing there, but associated sympathetic nerves, which are involved in the “fight or flight” response and were also found in the ovaries, appear to promote the growth of follicles.) And while estrogen and progesterone have long been thought of as the most important hormones produced by the ovaries, the organs churn out many more hormones and other chemicals—some of which were unknown to science until recently—that could play an important role in maintaining health. Clinical trials in the U.S. weren’t obliged to include women until 1993\. “If you look over the last 100 years of clinical and scientific data, it’s estimated that less than 10% of that is coming from female physiology,” says Frida Polli, a neuroscientist who helped launch a new machine-learning initiative at the Massachusetts Institute of Technology aimed at closing the women’s-health research gap. MIT’s [Female Medicine Through Machine Learning](https://fmml.mit.edu/) is using AI to parse through large health datasets to better understand potential drivers of ovarian aging, such as genetics and lifestyle factors. Polli says the goal is to find potential biomarkers of ovarian aging that could, for example, be used to predict the timing of menopause. There is currently no test that can directly measure the aging of ovarian tissue or even tell a woman for sure if she is going through perimenopause or menopause. At Princeton, geneticist Coleen Murphy is developing a blood test to measure aging in women that could predict the rate at which their ovaries are aging and when menopause may occur. Francesca Duncan, a reproductive-sciences professor at Northwestern, has discovered that as ovaries age, they become stiffer; her lab is working on an ultrasound test that uses ovarian stiffness as a way to measure ovarian aging. Women have been fueling the surge in innovation and investment in ovarian health, says Benayoun, the USC researcher whose work is focused on how inflammation could be driving ovarian aging. “Having a lot of new blood in the field and women rising in the ranks, opening labs, doing research, and being part of the dialogue has changed a lot of things,” she says. For many of these women, personal experience drew them to the work or kept them motivated. Murphy says it was her own experience with [family planning](https://time.com/5405987/history-of-contraception/) that made her realize there was a need for a test that could measure ovarian aging. Polli, of the MIT machine-learning initiative, says she became aware of how little was understood about ovarian health after unexpectedly getting pregnant at 46, while a friend in her early 30s suffered from primary ovarian insufficiency and needed donor eggs to conceive a child. Suh, the Columbia researcher, says she endured debilitating perimenopausal symptoms as she was starting her work on ovarian aging. “It totally shook my world. In hindsight, it’s a miracle that I maintained my lab, because my brain refused to work and my immune system failed,” she says. For Jamie Justice, a researcher of aging and executive director of [XPRIZE Healthspan](https://www.xprize.org/competitions/healthspan), a $101 million competition that awards advances in longevity science, challenging experiences during her own pregnancy prompted her, in part, to suggest an award for ovarian health. “I realized how little I understood about my own body,” she says. XPRIZE is currently fundraising for this new competition, which it hopes to launch in 2026\. The contest aims to award at least $50 million to a research group or company that develops a method to measure or better understand ovarian function and apply it to meaningfully improve women’s health. A lack of understanding of ovarian function is “one of the biggest gaps” in science, says Justice, who hopes the contest will generate enthusiasm for a field in urgent need of more investment. In 2023, only about 2% of all health-related venture-capital investments went to women’s health issues, according to a Deloitte analysis. Several initiatives have recently launched in an attempt to fix this gap, and some are focusing on breakthroughs in ovarian health. [Nuttall Women’s Health](https://www.nuttallwomenshealth.org/), a new nonprofit foundation, recently offered grants of up to $5 million to scientists studying ovarian aging. Another group, [AthenaDAO](https://www.athenadao.co/), is a grassroots community of researchers and investors that funds research using cryptocurrency. Since its founding in 2022, it has invested $1.5 million in projects related to ovarian function and other women’s health issues, says founder Laura Minquini. Its first spin-off company is focused on measuring ovarian decline and forecasting menopause. Of AthenaDAO’s 1,000 funders, about 800 are women, says Minquini. “We have members who are clinicians and researchers, but we also have women who aren’t scientists who have struggled with PCOS and endometriosis, so they are motivated by their own stories.” Garrison, the neuroscientist, says it’s about time for women’s health to take a front seat. “We are generations behind where we need to be with respect to women’s health knowledge,” she says. “We’ve got to do something different, something really big. 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