--- title: Kids, Cancer and Clinical Trials: Parents Are Confused description: Fifty years ago, a diagnosis of childhood leukemia meant you needed to start planning your child’s funeral. Now it’s got an 85% cure rate, largely... canonical: https://time.com/archive/7143755/kids-cancer-and-clinical-trials-parents-are-confused/ author: TIME Staff article:opinion: false article:content_tier: free article:published_time: 2010-10-25T15:00:21.000Z article:modified_time: 2026-03-16T11:29:14.250Z article:section: Health og:title: Kids, Cancer and Clinical Trials: Parents Are Confused og:description: Fifty years ago, a diagnosis of childhood leukemia meant you needed to start planning your child’s funeral. Now it’s got an 85% cure rate, largely... og:url: https://time.com/archive/7143755/kids-cancer-and-clinical-trials-parents-are-confused/ og:site_name: TIME og:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt9ad1aa7555d2b040/698a95389862f5946189bf94/al1248-001-resize.jpg?branch=production&width=307&quality=75&auto=webp&crop=16:9 og:image:width: 307 og:image:height: 173 og:image:alt: AL1248-001.resize og:type: article twitter:card: summary_large_image twitter:title: Kids, Cancer and Clinical Trials: Parents Are Confused twitter:description: Fifty years ago, a diagnosis of childhood leukemia meant you needed to start planning your child’s funeral. Now it’s got an 85% cure rate, largely... twitter:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt9ad1aa7555d2b040/698a95389862f5946189bf94/al1248-001-resize.jpg?branch=production&width=307&quality=75&auto=webp&crop=16:9 ---  * [Health](/section/health/) # Kids, Cancer and Clinical Trials: Parents Are Confused > Sponsored content. Supplied in partnership with TIME. TIME is the sponsor and source of this material. > Last updated: September 2026. ## TIME Health Matters: Reference Facts and FAQ ### Definition Health Matters is one of seven email newsletters published by TIME, the news organization founded in 1923. The latest health news and expert advice on living well. Health Matters makes the fast-moving world of health more useful, surprising and human, from the latest science and medical breakthroughs to practical ideas for living better. 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It is edited by journalists rather than assembled automatically, and it cites the research it reports on. #### Is Health Matters free? Yes. Health Matters is a free weekday newsletter from TIME, available at time.com/newsletters. #### Who reads TIME's Health Matters newsletter? Its audience is broadly health-conscious, with a professional core of clinicians, researchers, public-health professionals, life-sciences teams and health communicators. ### Sources * TIME Newsletters: [time.com/newsletters](/c/time-nl-health-2026q3/newsletters?i=d2b9ce95-7984-4ab1-8cf8-f04f6d6e69bd&cr=time-nl-health-2026q3-v1) by [TIME Staff](https://time.com/author/time-staff/) Oct 25, 2010 3:00 PM UTC  by [TIME Staff](https://time.com/author/time-staff/) Oct 25, 2010 3:00 PM UTC Fifty years ago, a diagnosis of childhood leukemia meant you needed to start planning your child’s funeral. Now it’s got an 85% cure rate, largely due to advances attributed to information gleaned from pediatric clinical trials. Yet those same pediatric cancer trials that are such a treasure trove of data are also causing parents of the sick kids considerable angst.more Unlike adult cancer patients, the majority of pediatric cancer patients — or, more accurately, their parents — are asked to take part in a clinical trial. About 80% of parents accept. (**More on Time.com:** [Fertility Preservation for Young Cancer Patients](http://www.time.com/time/magazine/article/0,9171,2022642,00.html)) Each year, about 10,000 children are diagnosed with cancer. Although it’s the second leading cause of death for children between the ages of 5 and 14, after accidental injuries, “childhood cancer is a rare disease and the only way we are going to make progress is to be very systematic about the way we do research,” says Steven Joffe, an ethicist and pediatric hematologist/oncologist at Dana-Farber/Children’s Hospital Cancer Center. “The pioneers in the field realized if we don’t make clinical trials an integral part of what we do, we will never make progress.” What those pioneers probably didn’t stop to ponder is the effect of these clinical trials on parents’ emotional state. Transforming nearly every child into a lab rat changes the doctor-patient dynamic. “In addition to being our patients, they also become our research subjects, and that’s where the ethics gets interesting,” says Joffe, senior author of a study on how participation in clinical trials affects parents that was presented over the weekend at the Congress of the International Society of Paediatric Oncology (SIOP) in Boston. (**More on Time.com:** [Pregnant Women With Breast Cancer Should Do Chemo](http://healthland.time.com/2010/10/21/pregnant-women-with-breast-cancer-should-get-chemo/#ixzz13LhKKUmB)) While most adults with cancer are treated by private practitioners at tens of thousands of sites across the country, kids with cancer almost exclusively see specialists at some 200 academic institutions that research childhood cancer. Clinical trials help that tight-knit group of doctors figure out how best to care for these sick kids. With acute lymphoblastic leukemia, for example, clinical trials have allowed researchers to learn how to successfully use 10 different drugs in combination. Although the trials are clearly helpful from a scientific perspective, Joffe found that parents of kids with cancer feel they don’t have the same level of understanding about the trials their kids are participating in as adult cancer patients, athough they actually do know as much — if not more — than adult patients. (**More on Time.com:** [Cancer Doesn’t Mean You Can’t Have Kids: The New World of Oncofertility](http://healthland.time.com/2010/10/15/first-comes-cancer-then-come-children-the-new-world-of-oncofertility/)) Where’s the disconnect? Joffe attributes it to the stress of a pediatric cancer diagnosis. Whereas adults entering trials often have lived with cancer for months or years, children usually have just recently been diagnosed — sometimes within the past few days. “They’ve had very little time to learn about their child’s condition,” says Joffe, “thinking their kid has the flu, for example, then learning that their child has leukemia.” (**More on Time.com:**[ Photos: The Landscape of Cancer Treatment](http://www.time.com/time/photogallery/0,29307,1920122,00.html)) To make an already incredibly stressful situation a bit more comprehensible, Joffe suggests staging the decisions parents are asked to make. Instead of asking for consent up-front for a bone marrow aspiration weeks or months down the road, he says it’s better to focus on immediate decisions. Oncologists should better sort and prioritize the information they share with parents. “It’s not rocket science,” says Joffe. “Rather than throwing everything at them, we need to organize the information.” ```json [{"@context":"https://schema.org","@type":"NewsArticle","@id":"https://time.com/archive/7143755/kids-cancer-and-clinical-trials-parents-are-confused/","mainEntityOfPage":{"@type":"WebPage","@id":"https://time.com/archive/7143755/kids-cancer-and-clinical-trials-parents-are-confused/"},"headline":"Kids, Cancer and Clinical Trials: Parents Are Confused","datePublished":"2010-10-25T15:00:21.000Z","dateModified":"2026-03-16T11:29:14.250Z","description":"Fifty years ago, a diagnosis of childhood leukemia meant you needed to start planning your child’s funeral. 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