--- title: Eli Lilly's Alzheimer's Drug Shows Greatest Benefit Yet description: Donanemab slowed cognitive decline in people with early Alzheimer’s disease by 35%, according to the company. canonical: https://time.com/6276651/alzheimers-drug-eli-lilly-donanemab/ author: Alice Park article:opinion: false article:content_tier: free article:published_time: 2023-05-03T16:17:51.000Z article:modified_time: 2026-08-04T07:51:14.604Z article:section: Health og:title: Eli Lilly's Alzheimer's Drug Shows Greatest Benefit Yet og:description: Donanemab slowed cognitive decline in people with early Alzheimer’s disease by 35%, according to the company og:url: https://time.com/6276651/alzheimers-drug-eli-lilly-donanemab/ og:site_name: TIME og:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt69ca4c96441cc44f/698a3c8947ca388e4e3babdb/dona-PET-images.jpg?branch=production&width=805&quality=75&auto=webp&crop=16:9 og:image:width: 805 og:image:height: 453 og:image:alt: dona PET images og:type: article twitter:card: summary_large_image twitter:title: Eli Lilly's Alzheimer's Drug Shows Greatest Benefit Yet twitter:description: Donanemab slowed cognitive decline in people with early Alzheimer’s disease by 35%, according to the company twitter:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt69ca4c96441cc44f/698a3c8947ca388e4e3babdb/dona-PET-images.jpg?branch=production&width=805&quality=75&auto=webp&crop=16:9 ---  # Eli Lilly's Alzheimer's Drug Shows Greatest Benefit Yet > Sponsored content. 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Scientists believe there is a future in which women can be vaccinated against breast cancer._  by [Alice Park](https://time.com/author/alice-park/)  ## Alice Park Senior Correspondent May 3, 2023 4:17 PM UTC  Brain scans show clearance of amyloid plaques, shown in red, in two patients, A and B, who received donanemab, compared to higher levels of amyloid in a patient who received placebo (bottom) in Eli Lilly's trial. Brain scans show clearance of amyloid plaques, shown in red, in two patients, A and B, who received donanemab, compared to higher levels of amyloid in a patient who received placebo (bottom) in Eli Lilly's trial. Eli Lilly  by [Alice Park](https://time.com/author/alice-park/)  ## Alice Park Senior Correspondent May 3, 2023 4:17 PM UTC In a May 3 [press release](https://investor.lilly.com/news-releases/news-release-details/lillys-donanemab-significantly-slowed-cognitive-and-functional), Eli Lilly announced encouraging results from its latest study of its Alzheimer’s drug candidate, donanemab. In the Phase 3 study, which included more than 1,000 people with early signs of Alzheimer’s disease, people receiving donanemab experienced 35% slower cognitive decline, as measured on cognitive tests, than people receiving placebo. In addition, those getting the drug showed 40% less decline in the ability to perform daily activities such as driving, managing their finances, and holding conversations. That’s an important metric for patients and their caregivers, as it can help more people live as independently as possible for as long as possible as the disease progresses. The results are the most encouraging yet for any drug that targets amyloid, the protein that builds up in the brains of Alzheimer’s patients and leads to a gradual culling of nerves involved in memory and other cognitive skills. “This further underscores the inflection point we are at for the Alzheimer’s field,” said Maria Carrillo, chief science officer for the Alzheimer’s Association, in a statement. “The progress we’ve seen in this class of treatments, as well as the diversification of potential new therapies over the past few years, provides hope to those impacted by this devastating disease.” --- ### More from TIME --- **Read More:** [_A New Alzheimer’s Drug Gave Patients Hope. Millions Can’t Get It_](http://A New Alzheimer's Drug Gave Patients Hope. Millions Can't Get It) The only drugs currently approved to treat Alzheimer’s—[aducanumab](https://time.com/6081333/biogen-alzheimers-drug-aduhelm-fda-controversy/) and [lecanemab](https://time.com/6244798/fda-approves-lecanemab-alzheimers-drug/)—slow cognitive decline to a lesser extent, and early promising studies on donanemab had Alzheimer’s experts hopeful that Eli Lilly’s drug would benefit patients to a greater extent. The company plans to request approval from the U.S. Food and Drug Administration (FDA) for donanemab for early Alzheimer’s patients this quarter, and will file additional applications for broader global approval. But even if does gain FDA approval, access to the medication could be an issue. Aducanumab, the first drug approved to treat Alzheimer’s, isn’t widely available, since the Centers for Medicare and Medicaid Services (CMS) decided it would only reimburse patients who use the drug if they are enrolled in a clinical study to continue researching the effectiveness of the medication. Coverage for lecanemab, the second [recently approved](https://time.com/6244798/fda-approves-lecanemab-alzheimers-drug/) drug, is [also restricted](https://time.com/6245670/lecanemab-medicare-costs-alzheimers-drug/) by CMS, since it also works by targeting amyloid.(The Veterans Affairs Administration, however, [does cover](https://www.va.gov/formularyadvisor/DOC%5FPDF/CFU%5FLecanemab-irmb%5FLEQEMBI%5FCFU.pdf) lecanemab for its beneficiaries.) CMS says it restricts coverage of anti-amyloid medications because these medications require further study before Medicare and Medicaid can reimburse all users. Under that policy, coverage of donanemab, despite its strong positive effect, could also be limited. “The Centers for Medicare & Medicaid Services (CMS) policy to block Medicare access to Food and Drug Administration (FDA)-approved Alzheimer’s treatments is in stark contrast to scientific evidence, is unprecedented and must be reversed immediately,” said Joanne Pike, president and CEO of the Alzheimer’s Association, in a statement. ```json [{"@context":"https://schema.org","@type":"NewsArticle","@id":"https://time.com/6276651/alzheimers-drug-eli-lilly-donanemab/","mainEntityOfPage":{"@type":"WebPage","@id":"https://time.com/6276651/alzheimers-drug-eli-lilly-donanemab/"},"headline":"Eli Lilly's Alzheimer's Drug Shows Greatest Benefit Yet","datePublished":"2023-05-03T16:17:51.000Z","dateModified":"2026-08-04T07:51:14.604Z","description":"Donanemab slowed cognitive decline in people with early Alzheimer’s disease by 35%, according to the company.","url":"https://time.com/6276651/alzheimers-drug-eli-lilly-donanemab/","keywords":["Drugs","healthscienceclimate"],"thumbnailUrl":"https://static.time.com/v3/assets/bltea6093859af6183b/blt69ca4c96441cc44f/698a3c8947ca388e4e3babdb/dona-PET-images.jpg?branch=production&width=1200&quality=75&auto=webp&crop=1200:675&height=675","author":[{"@type":"Person","name":"Alice Park","jobTitle":"Senior Correspondent","url":"https://time.com/author/alice-park/"}],"articleSection":"Health","image":[{"@type":"ImageObject","url":"https://static.time.com/v3/assets/bltea6093859af6183b/blt69ca4c96441cc44f/698a3c8947ca388e4e3babdb/dona-PET-images.jpg?branch=production&width=1200&quality=75&auto=webp&crop=1200:675&height=675","width":1200,"height":675,"headline":"dona PET images","caption":"Brain scans show clearance of amyloid plaques, shown in red, in two patients, A and B, who received donanemab, compared to higher levels of amyloid in a patient who received placebo (bottom) in Eli Lilly's trial.","creditText":"Eli Lilly","representativeOfPage":true}],"publisher":{"@type":"Organization","name":"Time","url":"https://time.com/","logo":{"@type":"ImageObject","url":"https://time.com/images/logo.png","width":528,"height":156},"foundingDate":"March 3, 1923","sameAs":["https://www.facebook.com/time","https://www.instagram.com/time/?hl=en","https://twitter.com/time","https://www.pinterest.com/timemagazine"]}},{"@context":"https://schema.org","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"/section/health/","name":"Health"}},{"@type":"ListItem","position":2,"item":{"@id":"/tag/drugs/","name":"Drugs"}},{"@type":"ListItem","position":3,"item":{"@id":"https://time.com/6276651/alzheimers-drug-eli-lilly-donanemab/","name":"Eli Lilly's Alzheimer's Drug Shows Greatest Benefit Yet"}}]},{"@context":"https://schema.org","@type":"VideoObject","name":"The Race to Make a Vaccine for Breast Cancer","description":"Scientists believe there is a future in which women can be vaccinated against breast cancer.","thumbnailUrl":"https://cdn.jwplayer.com/v2/media/W5jcvwLu/poster.jpg?width=720","uploadDate":"2022-10-05T20:44:13.000Z","contentUrl":"https://cdn.jwplayer.com/manifests/W5jcvwLu.m3u8","embedUrl":"https://time.com/6276651/alzheimers-drug-eli-lilly-donanemab/","duration":"PT8M9S","potentialAction":{"@type":"SeekToAction","target":"https://time.com/6276651/alzheimers-drug-eli-lilly-donanemab/?jw_start={seek_to_second_number}","startOffset-input":"required name=seek_to_second_number"}}] ```