--- title: Wendy Williams Has Frontotemporal Dementia. Here's What It Is description: Wendy Williams has frontotemporal dementia (FTD). Here's what to know about the condition. canonical: https://time.com/6256435/bruce-willis-frontotemporal-dementia/ author: Alice Park article:opinion: false article:content_tier: free article:published_time: 2023-02-17T17:16:32.000Z article:modified_time: 2024-02-22T20:12:30.000Z article:section: Health og:title: Wendy Williams Has Frontotemporal Dementia. Here's What It Is og:description: The condition is a rare form of dementia og:url: https://time.com/6256435/bruce-willis-frontotemporal-dementia/ og:site_name: TIME og:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt889a0544178f0f17/698a48ceb21a9c513a508882/Wendy-Williams_5f0de5.jpg?branch=production&width=1200&quality=75&auto=webp&crop=16:9 og:image:width: 4167 og:image:height: 2344 og:image:alt: Wendy Williams og:type: article twitter:card: summary_large_image twitter:title: Wendy Williams Has Frontotemporal Dementia. Here's What It Is twitter:description: The condition is a rare form of dementia twitter:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt889a0544178f0f17/698a48ceb21a9c513a508882/Wendy-Williams_5f0de5.jpg?branch=production&width=1200&quality=75&auto=webp&crop=16:9 ---  # Wendy Williams Has Frontotemporal Dementia. Here's What It Is > Sponsored content. Supplied in partnership with TIME. 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Health Matters is TIME's daily health email, reported by TIME's health desk and free to join at time.com/newsletters. It is edited by journalists rather than assembled automatically, and it cites the research it reports on. #### Is Health Matters free? Yes. Health Matters is a free daily newsletter from TIME, available at time.com/newsletters. #### Who reads TIME's Health Matters newsletter? Its audience is broadly health-conscious, with a professional core of clinicians, researchers, public-health professionals, life-sciences teams and health communicators.  by [Alice Park](https://time.com/author/alice-park/)  ## Alice Park Senior Correspondent Updated: Feb 22, 2024 8:12 PM UTCPublished: Feb 17, 2023 5:16 PM UTC  Wendy Williams is honored with Star on the Hollywood Walk of Fame on October 17, 2019 in Hollywood, California. Wendy Williams is honored with Star on the Hollywood Walk of Fame on October 17, 2019 in Hollywood, California.Axelle/Bauer-Griffin—FilmMagic  by [Alice Park](https://time.com/author/alice-park/)  ## Alice Park Senior Correspondent Updated: Feb 22, 2024 8:12 PM UTCPublished: Feb 17, 2023 5:16 PM UTC _This story was originally published in 2023 after Bruce Willis' diagnosis. We are updating it after the news of Wendy Williams' diagnosis in Feb. 2024._ Former talk show host Wendy Williams has been [diagnosed](https://time.com/6767929/wendy-williams-diagnosis-frontotemporal-dementia-apahasia/) with frontotemporal dementia (FTD), said her representatives in a [statement](https://www.prnewswire.com/news-releases/wendy-williams-diagnosed-with-primary-progressive-aphasia-and-dementia-302068851.html) on Feb. 22\. Williams also has primary progressive aphasia, a disorder of the nervous system that impairs a person’s ability to communicate. In recent years, Williams has openly shared her medical issues with audiences, including battles with substance abuse, lymphedema, and Graves’ disease. But "over the past few years, questions have been raised at times about Wendy’s ability to process information and many have speculated about Wendy’s condition, particularly when she began to lose words, act erratically at times, and have difficulty understanding financial transactions,” her representatives wrote in the statement. Other celebrities have recently been affected by FTD. In Feb. 2023, actor Bruce Willis’ family announced in an [Instagram post](https://www.instagram.com/p/Cou%5FX88Jxlq/?igshid=YmMyMTA2M2Y%3D) that he was diagnosed with the condition. His diagnosis came nearly a year after his family revealed Willis has [aphasia](https://time.com/6163559/aphasia-symptoms-bruce-willis/), which made it difficult for him to speak. Here’s what to know about FTD. ## What is FTD? FTD refers to a collection of conditions that involve deterioration of brain nerves in the frontal and temporal parts of the brain, which contribute to behavior, personality, and language. Aphasia may be a symptom of FTD. There are several types of FTD. One primarily affects behavior and personality, as nerves cells critical to judgement, conduct, and empathy start degenerating. Another, which affects language, speaking, and writing, most often occurs in midlife. Another type of FTD primarily damages motor nerves; amyotrophic lateral sclerosis, or ALS is a form of this type. Estimates of how many people are affected by FTD aren’t conclusive, but the Alzheimer’s Association [speculates](https://www.alz.org/alzheimers-dementia/what-is-dementia/types-of-dementia/frontotemporal-dementia) that about 50,000 to 60,000 people in the U.S. have the behavior and language versions of the condition. ## Is FTD the same as Alzheimer’s disease? While FTD involves the gradual loss of brain nerves, it differs from Alzheimer’s in important ways. Most people are diagnosed with FTD in their 40s to 60s, while Alzheimer’s patients are typically diagnosed later in life. Memory loss and disorientation are more common in Alzheimer’s than in FTD, while speech problems are more frequent in FTD. In FTD, patients develop abnormal deposits of one of two proteins—a form of a protein called tau and TDP-43—but not both. Patients with Alzheimer’s also build up tau, but it’s a different form from the one involved in FTD. It’s also typically more difficult to diagnose FTD. “There is an effort to develop blood, spinal fluid, and PET scan markers to diagnose FTD, but those are still in the works, and right now, we don’t have effective ways to test for FTD like we do for Alzheimer’s,” says Dr. Ryan Darby, director of the Frontotemporal Dementia Clinic at Vanderbilt University Medical Center. Doctors diagnose patients based on their suite of symptoms and sometimes with the help of brain scans, which can provide some useful hints but aren’t definitive. In addition, says Dr. Nicole Purcell, a neurologist and senior director of clinical practice at the Alzheimer’s Association, “we often do tests to rule out other types of dementia like Alzheimer’s dementia.” According to the Alzheimer’s Association, about a third of FTD cases are genetic, and there are no known risk factors for the non genetic cases, so it’s difficult to identify people who might develop the condition. Understanding which of the two proteins is abnormally building up is critical for developing the right treatments. Darby says that while some forms of language-related FTD involve TDP43, patients with behavioral symptoms can harbor excess forms of either protein, making it difficult to know which protein to target in drug trials. ## Are there treatments? While there is considerable research to better understand FTD and its causes, there are no treatments yet for the neurodegenerative condition. Anti-anxiety medications and antidepressants can ease some of the agitation and stress patients experience, but no therapies are available yet to combat the slow deterioration of neurons in the affected areas of the brain. Researchers are focusing on the genetic forms of the disease in order to learn more about how it works, and how best to intervene with possible treatments, says Dr. Claire Clelland, assistant professor of neurology at the University of California San Francisco. “We think that is the best and fastest path to clinical trials for new therapies,” she says. “In genetic cases through which we know the underlying cause from the gene mutation, we will learn about the disease more broadly so we can help more patients.” Research into the condition has picked up in recent years, and doctors who treat FTD patients at academic centers have collaborated to identify and monitor patients to pool information and be prepared to test promising new drug treatments when they are developed. “Our understanding of FTD really accelerated dramatically in the past two decades,” says Darby. “A lot of our understanding has come since the 1990s when we identified the clinical syndrome, and the gene for the most common inherited form wasn’t discovered until 2011\. A lot of innovation has happened recently, so a lot of us are optimistic that will translate into therapies.” Clelland shares that optimism. “These are becoming solvable problems,” she says. “My lab has already essentially cured patient cells in a dish. We just need to figure out how to deliver the therapy to patients.” Raising awareness about the condition, she says, will hopefully fuel more research. ```json [{"@context":"https://schema.org","@type":"NewsArticle","@id":"https://time.com/6256435/bruce-willis-frontotemporal-dementia/","mainEntityOfPage":{"@type":"WebPage","@id":"https://time.com/6256435/bruce-willis-frontotemporal-dementia/"},"headline":"Wendy Williams Has Frontotemporal Dementia. 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