--- title: Moderna Says Booster Doses of Its COVID-19 Vaccine Work description: Moderna tested three different COVID-19 vaccine booster shot approaches; two of them appear to be effective against variants of the virus. canonical: https://time.com/6046405/moderna-covid-19-vaccine-booster-study/ author: Alice Park article:opinion: false article:content_tier: free article:published_time: 2021-05-05T22:11:58.000Z article:modified_time: 2026-02-24T09:55:49.681Z article:section: Health og:title: Moderna Says Booster Doses of Its COVID-19 Vaccine Work og:description: Moderna tested three different COVID-19 vaccine booster shot approaches; two of them appear to be effective against variants of the virus. og:url: https://time.com/6046405/moderna-covid-19-vaccine-booster-study/ og:site_name: TIME og:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt54ab04be580522c1/698a195d4ee2622c8a318f31/GettyImages-1232677272.jpg?branch=production&width=1024&quality=75&auto=webp&crop=16:9 og:image:width: 1024 og:image:height: 576 og:image:alt: A health workers holds a vial of containing Moderna Covid-19 og:type: article twitter:card: summary_large_image twitter:title: Moderna Says Booster Doses of Its COVID-19 Vaccine Work twitter:description: Moderna tested three different COVID-19 vaccine booster shot approaches; two of them appear to be effective against variants of the virus. twitter:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt54ab04be580522c1/698a195d4ee2622c8a318f31/GettyImages-1232677272.jpg?branch=production&width=1024&quality=75&auto=webp&crop=16:9 ---  # Moderna Reports That Booster Doses of Its COVID-19 Vaccine Appear to Be Effective Against Virus Variants > Sponsored content. 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Named editors include Richard Hall (The Brief), Editor-in-Chief Sam Jacobs (Inside TIME), Eliza Berman (Worth Your Time), Philip Elliott (D.C. Brief), Justin Worland (Future Proof) and Harry Booth (In the Loop). Health Matters is written by TIME's health desk. #### How do I sign up for a TIME newsletter? Go to time.com/newsletters, choose the newsletters you want and enter your email address. There is no cost and no subscription requirement. ### Sources * TIME Newsletters: [time.com/newsletters](/c/time-nl-network-2026q3/newsletters?i=0d08091d-9406-465d-8dd6-3496911db4c3&cr=time-nl-network-2026q3-v1) ## Video: TIME 100 Most Influential Companies: Illumina [Watch (HLS stream): TIME 100 Most Influential Companies: Illumina](https://cdn.jwplayer.com/manifests/0El8LRPo.m3u8) (2:46)  _Published 2021-04-26. CEO of Illumina Francis De Souza discusses the benefits of genetic sequencing for our collective health and how the company's technology has assisted at every point of the pandemic to identify, test for and vaccinate against COVID-19._  by [Alice Park](https://time.com/author/alice-park/)  ## Alice Park Senior Correspondent May 5, 2021 10:11 PM UTC  KINGSTON, PENNSYLVANIA, UNITED STATES - 2021/05/03: A health workers holds a vial of containing Moderna Covid-19 vaccine at highrise for Aging individuals. The Luzerne County Emergency Management Agency and the Area Agency on Aging teamed up to provide COVID-19 vaccinations to homebound and elderly citizens. The group vaccinated residents at the Dan Flood Towers high-rise for elderly in Kingston, Pennsylvania. (Photo by Aimee Dilger/SOPA Images/LightRocket via Getty Images) KINGSTON, PENNSYLVANIA, UNITED STATES - 2021/05/03: A health workers holds a vial of containing Moderna Covid-19 vaccine at highrise for Aging individuals. The Luzerne County Emergency Management Agency and the Area Agency on Aging teamed up to provide COVID-19 vaccinations to homebound and elderly citizens. The group vaccinated residents at the Dan Flood Towers high-rise for elderly in Kingston, Pennsylvania. (Photo by Aimee Dilger/SOPA Images/LightRocket via Getty Images) SOPA Images/LightRocket—Getty Images  by [Alice Park](https://time.com/author/alice-park/)  ## Alice Park Senior Correspondent May 5, 2021 10:11 PM UTC In a press release on May 5, Moderna reported the first results of any vaccine maker from studies on booster doses of COVID-19 vaccines, which some experts believe might be necessary in a year or so to keep COVID-19 under control. Based on current research, people vaccinated with the existing, authorized shot from Moderna appear to have a diminished response to the variant viruses—although it’s still sufficient to protect against serious COVID-19 illness. Still, public health experts are concerned that the variant viruses could break through that vaccine protection and start causing more infections. The company is testing three ways to add a third dose to its current two-dose regimen to potentially increase protection against new variants of the SARS-CoV-2 virus. In its recent press release, Moderna reports on two of those strategies: adding a third dose of the existing vaccine, at half the dosage of the shots currently in use, and adding to the current two-shot regimen a third dose of a new vaccine the company developed specifically against the variant B.1.351 first identified in South Africa. Moderna is also investigating a combined vaccine booster that includes doses of both the existing vaccine and the new variant one—no results from that study are available yet. Both of the two strategies included in the recent press release are aimed at enhancing the body’s immune response to the South African variant, as well as to another one that was detected in Brazil, called P.1\. Moderna reports that both approaches appear to boost immune responses. Two weeks after receiving either the halved dose of the existing vaccine or the dose of the new variant vaccine, serum taken from vaccinated people in the study was able to neutralize lab versions of the mutated version of the SARS-CoV-2 virus at levels similar to or higher than against the non-variant strain. Moderna says that the boost with the new vaccine, which was designed to target the South African variant—perhaps unsurprisingly generated higher virus-neutralizing activity against the B.1.351 variant compared to the approach that used a third dose of the original vaccine. 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