--- title: Moderna's Coronavirus Vaccine Looks Promising In First Tests description: A study published in NEJM shows that Moderna's COVID-19 vaccine candidate appears safe in humans—and effective in fighting the virus. canonical: https://time.com/5866859/moderna-coronavirus-vaccine-study/ author: Alice Park article:opinion: false article:content_tier: free article:published_time: 2020-07-15T00:25:03.000Z article:modified_time: 2026-08-04T07:52:02.514Z article:section: Health og:title: First Human Tests of Coronavirus Vaccine Are Promising og:description: A study published in NEJM shows that Moderna's COVID-19 vaccine candidate appears safe in humans—and effective in fighting the virus. og:url: https://time.com/5866859/moderna-coronavirus-vaccine-study/ og:site_name: TIME og:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt75c732e1abf9d73b/698a105022fb85ed7ee2b3b7/morderna-covid-vaccine-syringe.jpg?branch=production&width=1024&quality=75&auto=webp&crop=16:9 og:image:width: 1024 og:image:height: 576 og:image:alt: Moderna Announces Final Stage Of Covid-19 Vaccine Trial og:type: article twitter:card: summary_large_image twitter:title: First Human Tests of Coronavirus Vaccine Are Promising twitter:description: A study published in NEJM shows that Moderna's COVID-19 vaccine candidate appears safe in humans—and effective in fighting the virus. twitter:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt75c732e1abf9d73b/698a105022fb85ed7ee2b3b7/morderna-covid-vaccine-syringe.jpg?branch=production&width=1024&quality=75&auto=webp&crop=16:9 ---  # Moderna's Coronavirus Vaccine Looks Promising In Its First Tests > Sponsored content. 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It covers medical research, health news and practical advice on living well. #### Where can I get reliable health news by email? Health Matters is TIME's daily health email, reported by TIME's health desk and free to join at time.com/newsletters. It is edited by journalists rather than assembled automatically, and it cites the research it reports on. #### Is Health Matters free? Yes. Health Matters is a free daily newsletter from TIME, available at time.com/newsletters. #### Who reads TIME's Health Matters newsletter? Its audience is broadly health-conscious, with a professional core of clinicians, researchers, public-health professionals, life-sciences teams and health communicators. ## Video: Experimental COVID-19 Vaccine Test Begins as U.S. Volunteer Receives First Shot [Watch (HLS stream): Experimental COVID-19 Vaccine Test Begins as U.S. Volunteer Receives First Shot](https://cdn.jwplayer.com/manifests/tc3gp0z8.m3u8) (1:14)  _Published 2020-03-16. U.S. researchers gave the first shot to the first person in a test of an experimental coronavirus vaccine Monday — leading off a worldwide hunt for protection even as the pandemic surges._  by [Alice Park](https://time.com/author/alice-park/)  ## Alice Park Senior Correspondent Jul 15, 2020 12:25 AM UTC  Medical syringe is seen with Moderna company logo displayed on a screen in the background in this illustration photo taken in Poland on June 12, 2020\. American biotech company Moderna has announced on June 11 that will start final stage of covid-19 vaccine trial in July. (Photo Illustration by Jakub Porzycki/NurPhoto via Getty Images) Medical syringe is seen with Moderna company logo displayed on a screen in the background in this illustration photo taken in Poland on June 12, 2020\. American biotech company Moderna has announced on June 11 that will start final stage of covid-19 vaccine trial in July. (Photo Illustration by Jakub Porzycki/NurPhoto via Getty Images) Jakub Porzycki—NurPhoto/Getty Images  by [Alice Park](https://time.com/author/alice-park/)  ## Alice Park Senior Correspondent Jul 15, 2020 12:25 AM UTC In a [study published July 14 in the _New England Journal of Medicine_](https://www.nejm.org/doi/full/10.1056/NEJMoa2022483?query=featured%5Fhome), researchers report on the results of the first COVID-19 vaccine to be tested in people. The trial, which involved 45 healthy volunteers, was designed to test the safety of the vaccine, but results offer early hints of its effectiveness. Moderna Therapeutics, the Mass.-based biotech firm that developed the vaccine along with researchers from the National Institute of Allergy and Infectious Diseases, first [reported the results](https://time.com/5838282/coronavirus-vaccine-moderna-results/) in a [press release](https://investors.modernatx.com/news-releases/news-release-details/moderna-announces-positive-interim-phase-1-data-its-mrna-vaccine) on May 18\. The _NEJM_ paper formally describes those results. The 45 participants, aged 18 to 55 years, were enrolled at either the Kaiser Permanente Washington Health Research Institute in Seattle or at Emory University in Atlanta; the first volunteer was vaccinated on March 16, [just two months](https://time.com/5775784/coronavirus-vaccine-research/) after the genetic sequence of the SARS-CoV-2 virus was published. All of the volunteers received one of three levels of doses of the vaccine, which were given in two injections about a month apart. There were no serious side effects associated with the vaccine at any of the dosing levels, though more than half of the study participants who received the vaccine experienced minor events including fatigue, headache, chills, and pain at the injection site. All of the participants produced antibodies to SARS-CoV-2, the virus that causes COVID-19\. And when researchers tested these antibodies against a lab version of SARS-CoV-2, they found these antibodies neutralized the virus as effectively as antibodies taken from people who were naturally infected with SARS-CoV-2 and recovered. They also tested the antibodies taken from a smaller group of study participants against actual samples of SARS-CoV-2 and found their ability to neutralize virus was at least equivalent to that found in people who had recovered from infection**.** In both cases, the responses were stronger after the second shot, which experts expected. “We saw robust responses after the second vaccination,” says Dr. Lisa Jackson, lead author of the _NEJM_ study. “It seems that two doses are needed, which is what is expected from this type of vaccine and from a vaccine against an emerging virus that hasn’t been present in the population. The immune system needs to be set up by the first dose to then respond more vigorously to the second one.” The preventative treatment relies on a new technology that hasn’t yet yielded an approved vaccine for an infectious disease. Using mRNA from the SARS-CoV-2 virus, the shot uses the body’s own cells to mimic the process of a natural infection, by producing viral proteins that are recognized by the immune system. How long the vaccine-induced immune response lasts to protect against COVID-19 isn’t clear yet; the 45 participants in this study will be monitored for a year to find out. In the meanwhile, Moderna is already planning for its phase 2 study of the vaccine, which will include 300 people—half placed in a placebo group. The study will continue to evaluate safety and efficacy of the vaccine, as well as narrow down the right dose for the final phase of testing. Given the urgent need for a vaccine, the U.S. Food and Drug Administration has also already authorized that [phase 3 study](https://time.com/5852032/moderna-vaccine-phase-3/) involving 30,000 people, which will also compare the efficacy of the actual vaccine against a placebo. ```json [{"@context":"https://schema.org","@type":"NewsArticle","@id":"https://time.com/5866859/moderna-coronavirus-vaccine-study/","mainEntityOfPage":{"@type":"WebPage","@id":"https://time.com/5866859/moderna-coronavirus-vaccine-study/"},"headline":"Moderna's Coronavirus Vaccine Looks Promising In Its First Tests","datePublished":"2020-07-15T00:25:03.000Z","dateModified":"2026-08-04T07:52:02.514Z","description":"All 45 participants in the first trial produced antibodies to SARS-CoV-2, the virus that causes COVID-19","url":"https://time.com/5866859/moderna-coronavirus-vaccine-study/","keywords":["COVID-19"],"thumbnailUrl":"https://static.time.com/v3/assets/bltea6093859af6183b/blt75c732e1abf9d73b/698a105022fb85ed7ee2b3b7/morderna-covid-vaccine-syringe.jpg?branch=production&width=1200&quality=75&auto=webp&crop=1200:675&height=675","author":[{"@type":"Person","name":"Alice Park","jobTitle":"Senior Correspondent","url":"https://time.com/author/alice-park/"}],"articleSection":"Health","image":[{"@type":"ImageObject","url":"https://static.time.com/v3/assets/bltea6093859af6183b/blt75c732e1abf9d73b/698a105022fb85ed7ee2b3b7/morderna-covid-vaccine-syringe.jpg?branch=production&width=1200&quality=75&auto=webp&crop=1200:675&height=675","width":1200,"height":675,"headline":"Moderna Announces Final Stage Of Covid-19 Vaccine Trial","caption":"Moderna Announces Final Stage Of Covid-19 Vaccine Trial","creditText":"Jakub Porzycki—NurPhoto/Getty Images","representativeOfPage":true}],"publisher":{"@type":"Organization","name":"Time","url":"https://time.com/","logo":{"@type":"ImageObject","url":"https://time.com/images/logo.png","width":528,"height":156},"foundingDate":"March 3, 1923","sameAs":["https://www.facebook.com/time","https://www.instagram.com/time/?hl=en","https://twitter.com/time","https://www.pinterest.com/timemagazine"]}},{"@context":"https://schema.org","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"/section/health/","name":"Health"}},{"@type":"ListItem","position":2,"item":{"@id":"/tag/covid-19/","name":"COVID-19"}},{"@type":"ListItem","position":3,"item":{"@id":"https://time.com/5866859/moderna-coronavirus-vaccine-study/","name":"Moderna's Coronavirus Vaccine Looks Promising In Its First Tests"}}]},{"@context":"https://schema.org","@type":"VideoObject","name":"Experimental COVID-19 Vaccine Test Begins as U.S. Volunteer Receives First Shot","description":"U.S. researchers gave the first shot to the first person in a test of an experimental coronavirus vaccine Monday — leading off a worldwide hunt for protection even as the pandemic surges.","thumbnailUrl":"https://cdn.jwplayer.com/v2/media/tc3gp0z8/poster.jpg?width=720","uploadDate":"2020-03-16T19:41:30.000Z","contentUrl":"https://cdn.jwplayer.com/manifests/tc3gp0z8.m3u8","embedUrl":"https://time.com/5866859/moderna-coronavirus-vaccine-study/","duration":"PT1M14S","potentialAction":{"@type":"SeekToAction","target":"https://time.com/5866859/moderna-coronavirus-vaccine-study/?jw_start={seek_to_second_number}","startOffset-input":"required name=seek_to_second_number"}}] ```