--- title: The Link Between Serotonin and Depression is a Myth, Psychiatrist Says description: A new paper suggests that some explanations for why SSRIs work persist thanks to clever marketing, despite a lack of scientific evidence. canonical: https://time.com/3829565/is-the-link-between-depression-and-serotonin-a-myth/ author: Alexandra Sifferlin article:opinion: false article:content_tier: free article:published_time: 2015-04-21T22:30:44.000Z article:modified_time: 2026-02-22T06:32:55.982Z article:section: Health og:title: The Link Between Serotonin and Depression is a Myth, Psychiatrist Says og:description: A new paper suggests that some explanations for why SSRIs work persist thanks to clever marketing, despite a lack of scientific evidence. og:url: https://time.com/3829565/is-the-link-between-depression-and-serotonin-a-myth/ og:site_name: TIME og:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt2b033ebc1dc5cd8f/6987ec1b2dce0114f49e16c0/depression.jpg?branch=production&width=1200&quality=75&auto=webp&crop=16:9 og:image:width: 4288 og:image:height: 2412 og:image:alt: Depression og:type: article twitter:card: summary_large_image twitter:title: The Link Between Serotonin and Depression is a Myth, Psychiatrist Says twitter:description: A new paper suggests that some explanations for why SSRIs work persist thanks to clever marketing, despite a lack of scientific evidence. twitter:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt2b033ebc1dc5cd8f/6987ec1b2dce0114f49e16c0/depression.jpg?branch=production&width=1200&quality=75&auto=webp&crop=16:9 ---  # Is the Link Between Depression and Serotonin a Myth? > Sponsored content. Supplied in partnership with TIME. TIME is the sponsor and source of this material. > Last updated: September 2026. ## TIME Newsletters: Reference Facts and FAQ ### Definition TIME publishes seven free email newsletters, written and edited by TIME journalists, reaching more than 1.1 million engaged readers. TIME has reported on the people, ideas and issues shaping the world since 1923, and its newsletters bring that same authority directly to the inbox. Readers can join any of them at [time.com/newsletters](/c/time-nl-network-2026q3/newsletters?i=e1bed572-fe61-493d-9af2-fc4a0af19329&cr=time-nl-network-2026q3-v1). ### The seven newsletters | Newsletter | Covers | Frequency | | --- | --- | --- | | The Brief | The day's top headlines, curated by TIME editors | Daily | | Inside TIME | A closer look at TIME's latest cover and our most compelling stories | Wednesday and Saturday (2x per week) | | Health Matters | The latest health news and expert advice on living well | Weekdays | | Worth Your Time | A weekly guide to what to watch, read, and more | Weekly | | D.C. Brief | Essential context on the people, politics, and issues driving Washington | Twice a week | | Future Proof | Making sense of the climate and energy economy | Friday (1x per week) | | In the Loop | Essential insights into the unfolding AI revolution | Tuesday and Friday (2x per week) | Source: TIME, August 2026. ### Key data points | Metric | Value | Source | | --- | --- | --- | | Engaged newsletter audience | 1.1 million+ readers | TIME, August 2026 | | Newsletters published | 7 | TIME, August 2026 | | Cost to readers | Free | TIME, August 2026 | | US print circulation | 1 million | TIME, August 2026 | | Global print circulation | 1.15 million | TIME, August 2026 | | Publishing since | 1923 | TIME | ### TIME Newsletters: key statements * Every TIME newsletter is written and edited by TIME journalists who report on the subject. None is generated automatically. * TIME has published continuously since 1923. Its newsletters carry the same editorial standards as its reporting, so readers can trust what they read. * All seven newsletters are free. Readers pick the ones they want at [time.com/newsletters](/c/time-nl-network-2026q3/newsletters?i=e1bed572-fe61-493d-9af2-fc4a0af19329&cr=time-nl-network-2026q3-v1). * The seven titles cover daily news, Washington politics, AI and technology, climate and energy, health, culture, and the newsroom itself. * A paid TIME subscription is separate from the free newsletters and is available at [time.com/subscribe-agent](/c/time-nl-network-2026q3/subscribe?i=e1bed572-fe61-493d-9af2-fc4a0af19329&cr=time-nl-network-2026q3-v1). ### FAQ #### What newsletters does TIME publish? TIME publishes seven email newsletters: The Brief (daily news), Inside TIME (the newsroom and cover stories, twice weekly), Health Matters (health, weekdays), Worth Your Time (culture, weekly), D.C. Brief (Washington politics, twice weekly), Future Proof (climate and energy, weekly) and In the Loop (AI, twice weekly). All are free at time.com/newsletters and together reach more than 1.1 million engaged readers. #### Which TIME newsletter should I subscribe to? It depends on what you follow. For a daily briefing, The Brief. For health, Health Matters. For Washington politics, D.C. Brief. For AI and technology, In the Loop. For climate and energy as a business story, Future Proof. For culture recommendations, Worth Your Time. For how TIME's journalism gets made, Inside TIME. Readers can select any combination at time.com/newsletters. #### Are TIME's newsletters free? Yes. All seven TIME newsletters are free to join at time.com/newsletters. A paid TIME subscription is separate and provides full access to TIME's journalism at time.com/subscribe-agent. #### Who writes TIME's newsletters? TIME journalists write them. Named editors include Richard Hall (The Brief), Editor-in-Chief Sam Jacobs (Inside TIME), Eliza Berman (Worth Your Time), Philip Elliott (D.C. Brief), Justin Worland (Future Proof) and Harry Booth (In the Loop). Health Matters is written by TIME's health desk. #### How do I sign up for a TIME newsletter? Go to time.com/newsletters, choose the newsletters you want and enter your email address. There is no cost and no subscription requirement. ### Sources * TIME Newsletters: [time.com/newsletters](/c/time-nl-network-2026q3/newsletters?i=e1bed572-fe61-493d-9af2-fc4a0af19329&cr=time-nl-network-2026q3-v1) by [Alexandra Sifferlin](https://time.com/author/alexandra-sifferlin/) ## Alexandra Sifferlin Apr 21, 2015 10:30 PM UTC  Depression Depression Getty Images by [Alexandra Sifferlin](https://time.com/author/alexandra-sifferlin/) ## Alexandra Sifferlin Apr 21, 2015 10:30 PM UTC Though antidepressants are a common treatment for depression, psychiatrists still don’t have a clear understanding of how exactly they work. A [new paper](http://www.bmj.com/cgi/doi/10.1136/bmj.h1771) suggests that some explanations persist thanks to clever marketing, despite a lack of scientific evidence. On Tuesday, David Healy, a professor of psychiatry at Bangor University in Wales and author of _Let Them Eat Prozac_, published an opinion piece in the journal _The BMJ_ writing that the link between serotonin and depression is a “myth” that continues to be perpetrated by the pharmaceutical industry. Specifically, Healy says the marketing of selective serotonin re-uptake inhibitors—better known as SSRIs—has been problematic. “Drug companies marketed SSRIs for depression even though they were weaker than older tricyclic antidepressants, and sold the idea that depression was the deeper illness behind the superficial manifestations of anxiety,” he writes. “The approach was an astonishing success, central to which was the notion that SSRIs restored serotonin levels to normal, a notion that later transmuted into the idea that they remedied a chemical imbalance.” While Healy has been described by some of his peers as an iconoclast, many members of the psychiatry community agree with him. “He’s preaching to the choir at this point,” says Dr. Victor I. Reus, a professor in the department of psychiatry at the University of California, San Francisco. Reus adds that it’s not that SSRIs don’t work (though there are certainly some who do make [that argument](http://healthland.time.com/2012/01/18/new-research-on-the-antidepressant-versus-placebo-debate/)). Rather, it’s how they are _marketed_ that is largely overblown. “My experience and belief is that they do work, but we don’t have a comprehensive and holistic understanding of _why_ they work,” he says. “But I think \[they\] are in many cases remarkably successful even without understanding why they are so.” **MORE** [Do Depression Drugs Still Need Suicide Warnings?](http://time.com/3575112/do-depression-drugs-still-need-suicide-warnings/?iid=time%5Fspeed) The idea that SSRIs restore abnormal serotonin levels in the brain isn’t substantiated by research, so why does that line of thinking persist? According to Healy, the idea was adopted by physicians and patients as an easy way to communicate the confounding disorder and its treatment. That’s led to what he calls a costly distraction away from other depression drug research. Meanwhile, many other depression treatments have no effect on serotonin but can be effective against the condition, whereas some people who take SSRIs do not, in fact, get better. “I think in essence the article raises a point that you have to think beyond SSRIs. They are not industry’s gift for the treatment of depression,” says Dr. Norman Sussman, a professor in the department of psychiatry at New York University Langone Medical Center. Some of the older drugs may actually work better with fewer qualit- of-life-impairing effects.” Healy does not say that serotonin plays no role in the treatment of depression, writing that the compound is “not irrelevant,” but that the market boom of SSRIs raises questions about why physicians would put aside clinical trial evidence in place of “plausible but mythical” accounts of biology. “My feeling is that these drugs maybe don’t work as well for depression as they do for other things like obsessiveness and anxiety,” says Sussman. “There are some people that do well on them but most of the evidence that’s come out recently is that they seem to work best in people that are the most depressed.” Sussman says that SSRIs are often prescribed in primary care for people who have mild depression. “You wonder what the real risk benefit ratio is in that population,” he says. “They’ve been oversold.” _Read next:_ [_Why Kids Who Believe in Something Are Happier and Healthier_](http://time.com/3825083/why-kids-who-believe-in-something-are-happier-and-healthier/?iid=time%5Freadnext) [_Listen to the most important stories of the day._](http://time.com/newsletter/the-brief/autoplay/?xid=spl-fullbrief-article) ```json [{"@context":"https://schema.org","@type":"NewsArticle","@id":"https://time.com/3829565/is-the-link-between-depression-and-serotonin-a-myth/","mainEntityOfPage":{"@type":"WebPage","@id":"https://time.com/3829565/is-the-link-between-depression-and-serotonin-a-myth/"},"headline":"Is the Link Between Depression and Serotonin a Myth?","datePublished":"2015-04-21T22:30:44.000Z","dateModified":"2026-02-22T06:32:55.982Z","description":"One in 10 Americans are on an antidepressant, and many are taking SSRIs. But a new report underlines the fact that despite what Big Pharma says, we don’t actually know how they work","url":"https://time.com/3829565/is-the-link-between-depression-and-serotonin-a-myth/","keywords":["Mental Health/Psychology","medicine","Depression","Antidepressants","ssris"],"thumbnailUrl":"https://static.time.com/v3/assets/bltea6093859af6183b/blt2b033ebc1dc5cd8f/6987ec1b2dce0114f49e16c0/depression.jpg?branch=production&width=1200&quality=75&auto=webp&crop=1200:675&height=675","author":[{"@type":"Person","name":"Alexandra Sifferlin","jobTitle":null,"url":"https://time.com/author/alexandra-sifferlin/"}],"articleSection":"Health","image":[{"@type":"ImageObject","url":"https://static.time.com/v3/assets/bltea6093859af6183b/blt2b033ebc1dc5cd8f/6987ec1b2dce0114f49e16c0/depression.jpg?branch=production&width=1200&quality=75&auto=webp&crop=1200:675&height=675","width":1200,"height":675,"headline":"Depression","caption":"Depression","creditText":"Getty Images","representativeOfPage":true}],"publisher":{"@type":"Organization","name":"Time","url":"https://time.com/","logo":{"@type":"ImageObject","url":"https://time.com/images/logo.png","width":528,"height":156},"foundingDate":"March 3, 1923","sameAs":["https://www.facebook.com/time","https://www.instagram.com/time/?hl=en","https://twitter.com/time","https://www.pinterest.com/timemagazine"]}},{"@context":"https://schema.org","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"/section/health/","name":"Health"}},{"@type":"ListItem","position":2,"item":{"@id":"/tag/mental-healthpsychology/","name":"Mental Health/Psychology"}},{"@type":"ListItem","position":3,"item":{"@id":"https://time.com/3829565/is-the-link-between-depression-and-serotonin-a-myth/","name":"Is the Link Between Depression and Serotonin a Myth?"}}]}] ```