--- title: Vaccine History: Everyone Wanted the Salk Polio Vaccine description: Feb. 23, 1954: The first mass inoculation of children against polio with the Salk vaccine takes place, in Pittsburgh canonical: https://time.com/3714090/salk-vaccine-history/ author: Jennifer Latson article:opinion: false article:content_tier: free article:published_time: 2015-02-23T15:30:09.000Z article:modified_time: 2026-02-22T04:31:44.836Z article:section: History og:title: Vaccine History: Everyone Wanted the Salk Polio Vaccine og:description: Feb. 23, 1954: The first mass inoculation of children against polio with the Salk vaccine takes place, in Pittsburgh og:url: https://time.com/3714090/salk-vaccine-history/ og:site_name: TIME og:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt2fd3f1e250ba5c25/69877fd78e0601573245a5d0/1101540329_400.jpg?branch=production&width=828&quality=75&auto=webp&crop=16:9 og:image:width: 1200 og:image:height: 675 og:image:alt: Salk Cover og:type: article twitter:card: summary_large_image twitter:title: Vaccine History: Everyone Wanted the Salk Polio Vaccine twitter:description: Feb. 23, 1954: The first mass inoculation of children against polio with the Salk vaccine takes place, in Pittsburgh twitter:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt2fd3f1e250ba5c25/69877fd78e0601573245a5d0/1101540329_400.jpg?branch=production&width=828&quality=75&auto=webp&crop=16:9 ---  # The Vaccine Everyone Wanted by [Jennifer Latson](https://time.com/author/jennifer-latson/) ## Jennifer Latson Feb 23, 2015 3:30 PM UTC  Jonas Salk on the Mar. 29, 1954, cover of TIME Jonas Salk on the Mar. 29, 1954, cover of TIMETIME by [Jennifer Latson](https://time.com/author/jennifer-latson/) ## Jennifer Latson Feb 23, 2015 3:30 PM UTC In the midst of the contentious debate between anti-vaxxers and those who side with mainstream science, it can be hard to imagine a time when Americans almost universally embraced vaccination. That time was the 1950s, when the very real, utterly devastating effects of polio overshadowed any hypothetical questions of vaccine safety. In 1952, the [worst polio outbreak](http://poliotoday.org/?page%5Fid=13) in American history infected 58,000 people, killing more than 3,000 and paralyzing 21,000 — the majority of them children. As [TIME reported](http://content.time.com/time/subscriber/article/0,33009,983118,00.html), “Parents were haunted by the stories of children stricken suddenly by the telltale cramps and fever. Public swimming pools were deserted for fear of contagion. And year after year polio delivered thousands of people into hospitals and wheelchairs, or into the nightmarish canisters called iron lungs.” When Dr. Jonas Salk’s vaccine debuted its first mass inoculation against polio on this day, Feb. 23, in 1954, the only fear most parents felt was that it wouldn’t become widely available fast enough to save their kids. Children from the Arsenal Elementary School in Pittsburgh, where Salk ran his research lab, took part in the first “field test” of the new vaccine, although Salk had already tried it on volunteers — [starting with himself, his wife, and their children](http://www.pbs.org/wgbh/aso/databank/entries/dm52sa.html) — who’d successfully produced polio antibodies without getting sick. By June, [nearly two million schoolchildren in 44 states](http://www.pbs.org/wgbh/americanexperience/features/introduction/polio-introduction/) had been inoculated, and a year later the vaccine was officially licensed. During its initial testing, the most salient safety question about Salk’s vaccine centered on the potential danger of injecting humans with monkey tissue. To make his vaccine, Salk’s team [harvested kidneys from live monkeys](http://content.time.com/time/subscriber/article/0,33009,819686-2,00.html) and injected them with live polio virus, which quickly multiplied in the kidney cells. Then the team used formaldehyde to kill the virus before injecting it into humans. But the traces of monkey kidney present in each dose of the vaccine were so minute that they posed no health risks, as [Salk told the New York _Times_](http://www.nytimes.com/learning/general/onthisday/big/0223.html#article). Instead, the greatest safety threat came not from monkeys but from human error: One of the labs licensed to produce the vaccine accidentally contaminated a batch with live polio virus in 1955\. That batch [killed five people and paralyzed 51](http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096324/). With stricter oversight, however, the vaccine continued to be the lifesaver it was initially hailed as. Within the first few years, it cut polio cases in the U.S. by half. By 1962, the number of new cases had dropped to fewer than 1,000\. And by the time of Salk’s death at age 80, 20 years ago, polio was already virtually extinct in the U.S. and dwindling worldwide. **_Read the 1954 cover story about the polio vaccine, here in the TIME archives_**: [Closing in on Polio](http://content.time.com/time/subscriber/article/0,33009,819686,00.html) Vaccine History: Everyone Wanted the Salk Polio Vaccine ```json [{"@context":"https://schema.org","@type":"NewsArticle","@id":"https://time.com/3714090/salk-vaccine-history/","mainEntityOfPage":{"@type":"WebPage","@id":"https://time.com/3714090/salk-vaccine-history/"},"headline":"The Vaccine Everyone Wanted","datePublished":"2015-02-23T15:30:09.000Z","dateModified":"2026-02-22T04:31:44.836Z","description":"Feb. 23, 1954: The first mass inoculation of children against polio with the Salk vaccine takes place, in Pittsburgh","url":"https://time.com/3714090/salk-vaccine-history/","keywords":["health","Vaccines"],"thumbnailUrl":"https://static.time.com/v3/assets/bltea6093859af6183b/blt2fd3f1e250ba5c25/69877fd78e0601573245a5d0/1101540329_400.jpg?branch=production&width=1200&quality=75&auto=webp&crop=1200:675&height=675","author":[{"@type":"Person","name":"Jennifer Latson","jobTitle":null,"url":"https://time.com/author/jennifer-latson/"}],"articleSection":"History","image":[{"@type":"ImageObject","url":"https://static.time.com/v3/assets/bltea6093859af6183b/blt2fd3f1e250ba5c25/69877fd78e0601573245a5d0/1101540329_400.jpg?branch=production&width=1200&quality=75&auto=webp&crop=1200:675&height=675","width":1200,"height":675,"headline":"Salk Cover","caption":"Salk Cover","creditText":"TIME","representativeOfPage":true}],"publisher":{"@type":"Organization","name":"Time","url":"https://time.com/","logo":{"@type":"ImageObject","url":"https://time.com/images/logo.png","width":528,"height":156},"foundingDate":"March 3, 1923","sameAs":["https://www.facebook.com/time","https://www.instagram.com/time/?hl=en","https://twitter.com/time","https://www.pinterest.com/timemagazine"]}},{"@context":"https://schema.org","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"/section/history/","name":"History"}},{"@type":"ListItem","position":2,"item":{"@id":"/tag/health/","name":"health"}},{"@type":"ListItem","position":3,"item":{"@id":"https://time.com/3714090/salk-vaccine-history/","name":"The Vaccine Everyone Wanted"}}]}] ```