Meyers began the segment by showing a clip of Biden on the popular educational children's show Where in the World is Carmen Sandiego? at which point Biden took the opportunity to poke fun at Republican presidential nominee Donald Trump.
" I have one regret, I wish Donald Trump had watched the show, he would’ve had a better sense of geography," Biden said.
Biden didn't just stop there, however; he then turned to Trump's recent controversial comments about being a "blue-collar worker."
" You watch it and think it can’t be happening," he said. "It’s a bunch of malarkey, he hasn’t’ the slightest notion of what it means to be a blue-collar worker."
He also addressed the recent allegations of sexual assault that Trump is facing, calling the mogul's behavior "outrageous" and calling the language captured on the leaked video the acknowledgment that "he engaged in the textbook definition of sexual assault," as he put it.
" The cardinal sin of all is a man raising his hand and taking advantage of women," Biden said. " I can’t understand how anyone can justify the abuse of power."
Watch the full interview below.