--- title: Breast Cancer Treatment Expectations Can Impact Side Effects description: Women who reported holding negative expectations of their breast cancer hormone therapy reported twice as many side effects in a new study. canonical: https://time.com/4462623/breast-cancer-treatment-expectations/ author: Alexandra Sifferlin article:opinion: false article:content_tier: free article:published_time: 2016-08-23T14:44:15.000Z article:modified_time: 2026-02-23T00:08:35.527Z article:section: Health og:title: How Low Expectations May Affect Breast Cancer Treatment og:description: Women who reported holding negative expectations of their breast cancer hormone therapy reported twice as many side effects in a new study. og:url: https://time.com/4462623/breast-cancer-treatment-expectations/ og:site_name: TIME og:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt936a5938ac00481d/698868f2cf40a8237cc4044e/breast-cancer-02.jpg?branch=production&width=1200&quality=75&auto=webp&crop=16:9 og:image:width: 2560 og:image:height: 1440 og:image:alt: breast cancer og:type: article twitter:card: summary_large_image twitter:title: How Low Expectations May Affect Breast Cancer Treatment twitter:description: Women who reported holding negative expectations of their breast cancer hormone therapy reported twice as many side effects in a new study. twitter:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt936a5938ac00481d/698868f2cf40a8237cc4044e/breast-cancer-02.jpg?branch=production&width=1200&quality=75&auto=webp&crop=16:9 ---  # How Having Low Expectations May Affect Breast Cancer Treatment > Sponsored content. 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There is no cost and no subscription requirement. ### Sources * TIME Newsletters: [time.com/newsletters](/c/time-nl-network-2026q3/newsletters?i=22f660a0-c47f-436c-8673-bc17be150543&cr=time-nl-network-2026q3-v1) by [Alexandra Sifferlin](https://time.com/author/alexandra-sifferlin/) ## Alexandra Sifferlin Aug 23, 2016 2:44 PM UTC  Patient waiting on examination table Patient waiting on examination table Getty Images (1); Illustration by Mia Tramz for TIME by [Alexandra Sifferlin](https://time.com/author/alexandra-sifferlin/) ## Alexandra Sifferlin Aug 23, 2016 2:44 PM UTC Women taking hormonal therapies as part of their [breast cancer treatment](http://time.com/4057310/breast-cancer-overtreatment/) experienced twice as many [side effects](http://time.com/3968918/when-chemotherapy-does-more-harm-than-good/) if they held negative expectations, compared to women who believed the side effects would not be as bad, [according to a new study](http://annonc.oxfordjournals.org/content/early/2016/08/02/annonc.mdw266.abstract). Side effects from treatment can influence how well a person adheres to it, the study authors argue, and understanding how expectations can impact side effects could spur the development of interventions to improve women’s experience. Published in the journal _Annals of_ _Oncology_, the study surveyed 111 women with [breast cancer](http://time.com/4142592/with-early-breast-cancer-treatment-less-may-be-more-studies/) who were taking hormonal therapies, like the drug Tamoxifen, at the start of their treatment and again two years later. They were asked what their expectations were about the treatment, including the severity of the side effects. By the end of the study, the women who had negative or highly negative views of what they were going to experience reported having double the side effects as other women. The side effects reported included weight gain, joint pain and hot flashes. But the researchers also noted that women reported side effects like back pain and breathing issues that, according to the study authors, could not be directly due to the drugs. Based on this, the researchers say negative thoughts about treatment may play a prominent role in people’s experience. The study size is small, and more research is needed to determine if these expectations really play a significant role. But the findings suggest that more can be done to find ways to help women manage their expectations and have better outcomes. Counseling designed to boost coping expectations and strategies to help patients reframe how they view their own side effects—getting them to see that discomfort can mean the therapy is working, for instance—are some potential tools that can help outcomes, the study authors say. ```json [{"@context":"https://schema.org","@type":"NewsArticle","@id":"https://time.com/4462623/breast-cancer-treatment-expectations/","mainEntityOfPage":{"@type":"WebPage","@id":"https://time.com/4462623/breast-cancer-treatment-expectations/"},"headline":"How Having Low Expectations May Affect Breast Cancer Treatment","datePublished":"2016-08-23T14:44:15.000Z","dateModified":"2026-02-23T00:08:35.527Z","description":"Women expecting the worst from breast cancer treatment experienced more side effects, in a new study","url":"https://time.com/4462623/breast-cancer-treatment-expectations/","keywords":["Cancer","Breast Cancer"],"thumbnailUrl":"https://static.time.com/v3/assets/bltea6093859af6183b/blt936a5938ac00481d/698868f2cf40a8237cc4044e/breast-cancer-02.jpg?branch=production&width=1200&quality=75&auto=webp&crop=1200:675&height=675","author":[{"@type":"Person","name":"Alexandra Sifferlin","jobTitle":null,"url":"https://time.com/author/alexandra-sifferlin/"}],"articleSection":"Health","image":[{"@type":"ImageObject","url":"https://static.time.com/v3/assets/bltea6093859af6183b/blt936a5938ac00481d/698868f2cf40a8237cc4044e/breast-cancer-02.jpg?branch=production&width=1200&quality=75&auto=webp&crop=1200:675&height=675","width":1200,"height":675,"headline":"breast cancer","caption":"breast cancer","creditText":"Getty Images (1); Illustration by Mia Tramz for TIME","representativeOfPage":true}],"publisher":{"@type":"Organization","name":"Time","url":"https://time.com/","logo":{"@type":"ImageObject","url":"https://time.com/images/logo.png","width":528,"height":156},"foundingDate":"March 3, 1923","sameAs":["https://www.facebook.com/time","https://www.instagram.com/time/?hl=en","https://twitter.com/time","https://www.pinterest.com/timemagazine"]}},{"@context":"https://schema.org","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https://time.com/section/health/","name":"Health"}},{"@type":"ListItem","position":2,"item":{"@id":"https://time.com/tag/cancer/","name":"Cancer"}},{"@type":"ListItem","position":3,"item":{"@id":"https://time.com/4462623/breast-cancer-treatment-expectations/","name":"How Having Low Expectations May Affect Breast Cancer Treatment"}}]}] ```