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title: Treating Diabetes: Why Aggressive Treatment May Backfire
description: Overtreating type-2 diabetes can lead to severe side effects including hypoglycemia, fainting and seizures
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author: Alice Park
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article:published_time: 2016-06-06T15:00:40.000Z
article:modified_time: 2026-02-22T22:23:16.652Z
article:section: Health
og:title: Doctors Warn That We May Be Over Treating Diabetes
og:description: Overtreating type-2 diabetes can lead to severe side effects including hypoglycemia, fainting and seizures
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og:image:alt: Man using a Glucose Reader.
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twitter:title: Doctors Warn That We May Be Over Treating Diabetes
twitter:description: Overtreating type-2 diabetes can lead to severe side effects including hypoglycemia, fainting and seizures
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# Overtreating Diabetes Can Have Serious Consequences, Experts Warn

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> Last updated: August 2026.

## TIME Newsletters: Reference Facts and FAQ

### Definition

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### The seven newsletters

| Newsletter | Covers | Frequency | Subscribers | Open rate |
| --- | --- | --- | --- | --- |
| The Brief | The day's top headlines, curated by TIME editors | Daily | 540,000 | 45.6% |
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Source: TIME, August 2026. Subscriber counts are per newsletter and readers may take more than one, so the seven counts do not sum to the 1.1 million+ unique newsletter audience.

### Key data points

| Metric | Value | Source |
| --- | --- | --- |
| Engaged newsletter audience | 1.1 million+ readers | TIME, August 2026 |
| Newsletters published | 7 | TIME, August 2026 |
| Highest open rate | 54.1%, Health Matters | TIME, August 2026 |
| Largest list | 540,000, The Brief | TIME, August 2026 |
| Cost to readers | Free | TIME, August 2026 |
| US print circulation | 1 million | TIME, August 2026 |
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| Publishing since | 1923 | TIME |

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### FAQ

#### What newsletters does TIME publish?

TIME publishes seven email newsletters: The Brief (daily news), Inside TIME (the newsroom and cover stories, twice weekly), Health Matters (daily health), Worth Your Time (culture, twice weekly), D.C. Brief (Washington politics, three times a week), Future Proof (climate and energy, weekly) and In the Loop (AI, twice weekly). All are free at time.com/newsletters and together reach more than 1.1 million engaged readers.

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#### How do I sign up for a TIME newsletter?

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![Alice Park](https://static.time.com/v3/assets/bltea6093859af6183b/blt9b1ff6b12c3a4c3f/698a0b4397cdff3e366ba723/200116_Time_Headshots_Day552832-e1583529256299.jpg?branch=production&width=1200&quality=75&auto=webp&crop=1:1)

by 

[Alice Park](https://time.com/author/alice-park/)


![Alice Park](https://static.time.com/v3/assets/bltea6093859af6183b/blt9b1ff6b12c3a4c3f/698a0b4397cdff3e366ba723/200116_Time_Headshots_Day552832-e1583529256299.jpg?branch=production&width=96&quality=75&auto=webp)

## Alice Park


Senior Correspondent

Jun 6, 2016 3:00 PM UTC

![Man using a Glucose Reader.](https://static.time.com/v3/assets/bltea6093859af6183b/bltec22053f6058b512/69889658524fc0737cdf8434/gettyimages-98551012.jpg?branch=production&width=1200&quality=75&auto=webp&crop=3:2)

Man using a Glucose Reader.

Man using a Glucose Reader. ballyscanlon—Getty Images

![Alice Park](https://static.time.com/v3/assets/bltea6093859af6183b/blt9b1ff6b12c3a4c3f/698a0b4397cdff3e366ba723/200116_Time_Headshots_Day552832-e1583529256299.jpg?branch=production&width=1200&quality=75&auto=webp&crop=1:1)

by 

[Alice Park](https://time.com/author/alice-park/)


![Alice Park](https://static.time.com/v3/assets/bltea6093859af6183b/blt9b1ff6b12c3a4c3f/698a0b4397cdff3e366ba723/200116_Time_Headshots_Day552832-e1583529256299.jpg?branch=production&width=96&quality=75&auto=webp)

## Alice Park


Senior Correspondent

Jun 6, 2016 3:00 PM UTC

With type-2 diabetes, it’s important to keep blood sugar under control, but there’s also a danger in using too many drugs to bring levels to unhealthy lows, says Dr. Rozalina McCoy, from the Mayo Clinic.

McCoy and her colleagues [report in _JAMA Internal Medicine_](http://archinte.jamanetwork.com/article.aspx?doi=10.1001/jamainternmed.2016.2275) about a study of more than 31,000 adults with [type 2 diabetes](http://time.com/65830/heart-attacks-strokes-related-to-type-2-diabetes-drop-dramatically/). They analyzed those who were treated aggressively to see how often they experienced dangerously low levels of blood sugar requiring hospitalization or other medical care. They considered aggressive treatment any case in which people were taking multiple medications to keep their blood sugar levels down.

About 20% of the people in the study fit this category, and such aggressive treatment, says McCoy, might have actually done them more harm than good. For people who are older and have other health problems, aggressive treatment of their diabetes led to a complications including dizziness, fainting and in sever cases, seizures and coma.

“Our goal in managing diabetes is to really get people’s blood sugar into a safe, normal range. Which means not too high—but it also means not be too low,” says McCoy. “And this applies to many people, not just the people in the study.”

While the risk was highest for people who are older and those with other health problems, McCoy says there is a lesson for everyone with diabetes, and for the doctors who treat them. “In an effort to reduce undertreatment, and to make sure patients are tested and receive the appropriate treatment medications, we don’t have a counterbalance to ensure that patients are not over treated.”


She points to several factors in the aggressive over treatment, the most important of which are guidelines and recommendations that focus on reducing blood sugar _without_ a companion emphasis on warning against what levels can be too low. The long-term health dangers to high blood sugar include damage to the kidneys, eyes and risk of amputation. The harms of low blood sugar are more immediate, and should also be part of any doctor’s treatment of people with diabetes, McCoy says.

She hopes the results of the study serve as a lesson for all doctors, not just those who treat people with diabetes. “The same principle applies to many chronic diseases,” she says. “We may hurt patients in our desire to help them if we do too much.”

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