No injuries or deaths were reported and the highway reopened by 9 a.m., according to the AP. About 17 inches of snow fell on the area between Friday and Saturday.
The backup on the interstate started with vehicle accidents caused by snow.
Kentucky State Police Capt. David Jude told CNN that there was "truck after truck after truck and cars sliding off the roadway."
"We're going car to car now to get people off the road," Jude said.
Police and the National Guard went out onto the snow-covered highway to check on those stranded in their cars, and the Red Cross set up shelters. Emergency crews passed out food and water.
A band that tours nationally to play weddings and other events live-tweeted their experience being stuck in the storm and posted videos on Facebook and YouTube.
They went out in the storm to play music for trapped motorists:
They were stuck all night:
Eventually they got moving again:
Others tweeted photos of the snow: