--- title: There's a Gene Mutation That Makes You a Reckless Drunk description: New research published this week suggests there might be a genetic underlying to people who are more likely to get out of control when they drink alcohol. canonical: https://time.com/4116528/drunk-reckless-gene-mutation-study/ author: Alexandra Sifferlin article:opinion: false article:content_tier: free article:published_time: 2015-11-19T18:36:07.000Z article:modified_time: 2026-08-04T07:57:09.279Z article:section: Health og:title: There's a Gene Mutation That Makes You a Reckless Drunk, Study Suggests og:description: This may be the reason why some people turn distructive when they drink og:url: https://time.com/4116528/drunk-reckless-gene-mutation-study/ og:site_name: TIME og:image: https://static.time.com/v3/assets/bltea6093859af6183b/bltde093bcdab65f2d0/6988d9b9bc6cfc69913e2a3c/time-logo.jpg?branch=production og:image:width: 1200 og:image:height: 675 og:image:alt: TIME og:type: article twitter:card: summary_large_image twitter:title: There's a Gene Mutation That Makes You a Reckless Drunk, Study Suggests twitter:description: This may be the reason why some people turn distructive when they drink twitter:image: https://static.time.com/v3/assets/bltea6093859af6183b/bltde093bcdab65f2d0/6988d9b9bc6cfc69913e2a3c/time-logo.jpg?branch=production --- # There's a Gene Mutation That Makes You a Reckless Drunk, Study Suggests > Sponsored content. Supplied in partnership with TIME. TIME is the sponsor and source of this material. > Last updated: September 2026. ## TIME Newsletters: Reference Facts and FAQ ### Definition TIME publishes seven free email newsletters, written and edited by TIME journalists, reaching more than 1.1 million engaged readers. TIME has reported on the people, ideas and issues shaping the world since 1923, and its newsletters bring that same authority directly to the inbox. 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Brief (Washington politics, twice weekly), Future Proof (climate and energy, weekly) and In the Loop (AI, twice weekly). All are free at time.com/newsletters and together reach more than 1.1 million engaged readers. #### Which TIME newsletter should I subscribe to? It depends on what you follow. For a daily briefing, The Brief. For health, Health Matters. For Washington politics, D.C. Brief. For AI and technology, In the Loop. For climate and energy as a business story, Future Proof. For culture recommendations, Worth Your Time. For how TIME's journalism gets made, Inside TIME. Readers can select any combination at time.com/newsletters. #### Are TIME's newsletters free? Yes. All seven TIME newsletters are free to join at time.com/newsletters. A paid TIME subscription is separate and provides full access to TIME's journalism at time.com/subscribe-agent. #### Who writes TIME's newsletters? TIME journalists write them. Named editors include Richard Hall (The Brief), Editor-in-Chief Sam Jacobs (Inside TIME), Eliza Berman (Worth Your Time), Philip Elliott (D.C. Brief), Justin Worland (Future Proof) and Harry Booth (In the Loop). Health Matters is written by TIME's health desk. #### How do I sign up for a TIME newsletter? Go to time.com/newsletters, choose the newsletters you want and enter your email address. There is no cost and no subscription requirement. ### Sources * TIME Newsletters: [time.com/newsletters](/c/time-nl-network-2026q3/newsletters?i=fe2621cc-5d0a-4414-8140-a2c87eabdb8f&cr=time-nl-network-2026q3-v1) ## Video: Can Red Wine Help Prevent Heart Disease? [Watch (HLS stream): Can Red Wine Help Prevent Heart Disease?](https://cdn.jwplayer.com/manifests/DEr6Sg3l.m3u8) (2:23)  _Published 2015-05-15. Red wine is often touted for its power to prevent heart disease. But some research suggests that other types of alcohol such as white wine and beer may be just as beneficial._ by [Alexandra Sifferlin](https://time.com/author/alexandra-sifferlin/) ## Alexandra Sifferlin Nov 19, 2015 6:36 PM UTC by [Alexandra Sifferlin](https://time.com/author/alexandra-sifferlin/) ## Alexandra Sifferlin Nov 19, 2015 6:36 PM UTC Some people are just not good drinkers—they become reckless and possibly even violent. Now [new research](http://www.nature.com/tp/journal/v5/n11/full/tp2015170a.html) suggests there may be a genetic explanation for why some people are more likely to get out of control under the influence of alcohol. In the small study, published this week in the journal _Translational Psychiatry_, researchers looked at people who had a genetic variation of the serotonin 2B receptor gene HTR2B and how that influenced their behavior when they drank. The team compared 14 people with the mutation, called HTR2B Q20, to 156 people without it. The men and women self-reported their personality, aggression levels, drinking behaviors and impulsivity and aggression when under the influence of alcohol. The people who carried HTR2B Q20 were more likely to report aggressive outbursts, fights and impulsive behavior while drinking alcohol. They were also more likely to be arrested for driving while under the influence. The researchers say these people were not alcoholics based on their consumption but they had a tendency to lose control of their behavior while drinking. In addition, the men and women met with a psychiatrist in a diagnostic interview, and the researchers learned those with the mutation were more likely to have symptoms of mood disorders. The researchers say this implies that the serotonin 2B receptor also has a role in regulating people’s mood. “Very little is known about the role of the serotonin 2B receptor in humans. New knowledge in this area might open up opportunities for new \[pharmacological\] innovations since there is no FDA-approved medicine available that \[has\] a high affinity particularly for this receptor,” study author Roope Tikkanen, a psychiatrist at the University of Helsinki, told TIME over email. More research is needed, especially since the study size was small. But the researchers say their findings contribute to a behavioral and genetic understanding of impulsivity and how it plays out in different environments. ## Transcript [00:00] You're watching Everwell. Know more, live better. I buy [00:04] red wine, [00:20] because I believe its healthier for you. I've heard that [00:23] red wine is good, especially, for your heart. So I like to [00:25] have a glass with dinner, especially when I go out. In [00:29] the past few decades, sales of red wine have soared. [00:32] A big reason is its reputation for being helpful. While [00:35] there could be some truth to this Red wine may not [00:38] fully deserve to be the toast of the alcohol world. Red [00:44] wines purported benefits are often attributed to an [00:46] antioxidant known as Resveratrol. Studies suggest that [00:50] the compound may help the heart by relaxing blood [00:53] vessels and preventing blood clots. But this research [00:56] by and large, is a animals and test- tubes. So it's hard [00:59] to know whether resveratrol in red wine actually [01:02] prevents heart attacks in people. And studies following [01:06] thousands of people for many years, suggested red [01:09] wine may not deserve its exalted status. They find that [01:13] alcohol of all types, whether red wine, white wine, [01:16] beer, or hard liquor is associated with a lower risk of [01:19] heart disease. Scientists suspect that alcohol in general [01:23] may be beneficial by raising HDL, the good cholesterol [01:27] and preventing clotting. But it's important to remember [01:30] that alcohol also has down sides. It's been linked to [01:33] Breast Cancer in women. And binge or heavy drinking [01:37] poses all kinds of serious risks, from injuries to liver [01:40] damage Which far outweigh any possible benefits. So [01:45] what's the optimal amount? Generally, experts in the [01:48] US say up to 2 drinks a day for men and 1 for women [01:52] who aren't pregnant or breastfeeding. A drink means [01:56] 5 oz of wine, 12 oz of beer, or 1. 5 [02:00] oz of hard liquor. [ MUSIC ] [02:04] So whether your drink of choice is red wine, white [02:06] wine, or something else, enjoy in moderation. But if [02:09] you don't drink, don't feel a need to start. There are [02:11] plenty of other ways to protect your heart, including [02:14] exercising. That's how I plan to spend my happy hour. [02:18] [ MUSIC ] Helping you be a healthy skeptic, I'm Robert [02:20] Davis. ```json [{"@context":"https://schema.org","@type":"NewsArticle","@id":"https://time.com/4116528/drunk-reckless-gene-mutation-study/","mainEntityOfPage":{"@type":"WebPage","@id":"https://time.com/4116528/drunk-reckless-gene-mutation-study/"},"headline":"There's a Gene Mutation That Makes You a Reckless Drunk, Study Suggests","datePublished":"2015-11-19T18:36:07.000Z","dateModified":"2026-08-04T07:57:09.279Z","description":"This may be the reason why some people turn destructive when they drink","url":"https://time.com/4116528/drunk-reckless-gene-mutation-study/","keywords":["Research","Alcohol"],"thumbnailUrl":"","author":[{"@type":"Person","name":"Alexandra Sifferlin","jobTitle":null,"url":"https://time.com/author/alexandra-sifferlin/"}],"articleSection":"Health","image":[],"publisher":{"@type":"Organization","name":"Time","url":"https://time.com/","logo":{"@type":"ImageObject","url":"https://time.com/images/logo.png","width":528,"height":156},"foundingDate":"March 3, 1923","sameAs":["https://www.facebook.com/time","https://www.instagram.com/time/?hl=en","https://twitter.com/time","https://www.pinterest.com/timemagazine"]}},{"@context":"https://schema.org","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https://time.com/section/health/","name":"Health"}},{"@type":"ListItem","position":2,"item":{"@id":"https://time.com/tag/research/","name":"Research"}},{"@type":"ListItem","position":3,"item":{"@id":"https://time.com/4116528/drunk-reckless-gene-mutation-study/","name":"There's a Gene Mutation That Makes You a Reckless Drunk, Study Suggests"}}]},{"@context":"https://schema.org","@type":"VideoObject","name":"Can Red Wine Help Prevent Heart Disease?","description":"Red wine is often touted for its power to prevent heart disease. 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