--- title: The First-Ever Malaria Vaccine Just Got A Big Break description: After nearly 30 years of development and testing, the world's first malaria vaccine Mosquirix took a major step forward canonical: https://time.com/3970282/malaria-vaccine-approved/ author: Alexandra Sifferlin article:opinion: false article:content_tier: free article:published_time: 2015-07-24T05:00:36.000Z article:modified_time: 2026-08-04T07:58:26.149Z article:section: Health og:title: The First-Ever Malaria Vaccine Just Got A Big Break og:description: After nearly 30 years of development and testing, the world's first malaria vaccine Mosquirix took a major step forward og:url: https://time.com/3970282/malaria-vaccine-approved/ og:site_name: TIME og:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt72d574357b555cac/6987789b3c1639079745105c/health-syringe-needle-6.jpg?branch=production&width=1200&quality=75&auto=webp&crop=16:9 og:image:width: 2560 og:image:height: 1440 og:image:alt: TIME.com stock photos Health Syringe Needle og:type: article twitter:card: summary_large_image twitter:title: The First-Ever Malaria Vaccine Just Got A Big Break twitter:description: After nearly 30 years of development and testing, the world's first malaria vaccine Mosquirix took a major step forward twitter:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt72d574357b555cac/6987789b3c1639079745105c/health-syringe-needle-6.jpg?branch=production&width=1200&quality=75&auto=webp&crop=16:9 ---  # The First-Ever Malaria Vaccine Just Got a Big Break > Sponsored content. 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Dr. Kent Brantly and other health care workers talk about surviving Ebola_ by [Alexandra Sifferlin](https://time.com/author/alexandra-sifferlin/) ## Alexandra Sifferlin Jul 24, 2015 5:00 AM UTC  Elizabeth Renstrom—TIME by [Alexandra Sifferlin](https://time.com/author/alexandra-sifferlin/) ## Alexandra Sifferlin Jul 24, 2015 5:00 AM UTC After nearly 30 years of development and testing, the world’s first malaria vaccine got a major push forward on Friday morning. Drug maker GlaxoSmithKline announced that a European Medicines Agency (EMA) committee has given a positive recommendation for the company’s vaccine for malaria called Mosquirix (scientifically known as RTS,S). The drug is intended for children ages six weeks to 17 months living in Sub-Saharan Africa. Because the vaccine is not intended for countries outside of Africa, the European regulatory agency is not “approving” the vaccine, but offering a positive opinion that the World Health Organization (WHO) will use to create its own recommendation for the vaccine’s use. Countries in Africa will then approve the vaccine through their own regulatory agencies. Mosquirix is the first vaccine to prevent malaria in humans and was first created in 1987. The data assessed by the EMA was primarily from a phase III clinical trial of the vaccine in about 16,000 kids in multiple African countries. After 18 months, GSK reported that the vaccine had about 46% efficacy against clinical malaria and 36% efficacy against severe malaria in kids ages five to 17 months. In babies ages six to 12 weeks, the drug had a 27% efficacy against clinical malaria and 15% against severe malaria. The efficacy rates may seem low, but the researchers tell TIME that the vaccine is the only one available thus far and will save a significant number of lives that would be lost to the mosquito-borne disease. The vaccine also shows efficacy for a few years after initial vaccination. “Is there room for improvement? Yes. We can improve a lot,” says Moncef Slaoui, co-inventor of the vaccine and the Chairman of GSK Vaccines, in an interview with TIME. At the end of the study period, the researchers found that more than 6,000 cases of clinical malaria were prevented for every 1,000 children who were vaccinated in areas of high transmission. The efficacy of the vaccine was also assessed in a safe study context in which children slept with bed nets treated with insecticide, a measure not always taken. According to data provided by GSK, there were 584,000 deaths worldwide from malaria in 2013, and 90% of those deaths took place in Sub-Saharan Africa. More than 80% of the deaths occurred in kids under age five. Currently, the vaccine Mosquirix requires four doses. The first three happen a month apart from each other, and the fourth happens about 18 months later. Ensuring that parents get their children the full dosage can be challenging, but Slaoui notes that most infant vaccines require multiple doses, and while not ideal, there’s still a significant benefit with just three doses. Slaoui says GSK also has a second generation version of the vaccine in the works—one that may have even better efficacy rates. “It’s a tweak of the current vaccine,” he says. “We know the next generation is close by.” ```json [{"@context":"https://schema.org","@type":"NewsArticle","@id":"https://time.com/3970282/malaria-vaccine-approved/","mainEntityOfPage":{"@type":"WebPage","@id":"https://time.com/3970282/malaria-vaccine-approved/"},"headline":"The First-Ever Malaria Vaccine Just Got a Big Break","datePublished":"2015-07-24T05:00:36.000Z","dateModified":"2026-08-04T07:58:26.149Z","description":"Drugmakers received a thumbs up from European regulators, moving the vaccine closer to human use","url":"https://time.com/3970282/malaria-vaccine-approved/","keywords":["medicine","Africa","Malaria","vaccine"],"thumbnailUrl":"https://static.time.com/v3/assets/bltea6093859af6183b/blt72d574357b555cac/6987789b3c1639079745105c/health-syringe-needle-6.jpg?branch=production&width=1200&quality=75&auto=webp&crop=1200:675&height=675","author":[{"@type":"Person","name":"Alexandra Sifferlin","jobTitle":null,"url":"https://time.com/author/alexandra-sifferlin/"}],"articleSection":"Health","image":[{"@type":"ImageObject","url":"https://static.time.com/v3/assets/bltea6093859af6183b/blt72d574357b555cac/6987789b3c1639079745105c/health-syringe-needle-6.jpg?branch=production&width=1200&quality=75&auto=webp&crop=1200:675&height=675","width":1200,"height":675,"headline":"TIME.com stock photos Health Syringe Needle","caption":"TIME.com stock photos Health Syringe Needle","creditText":"Elizabeth Renstrom—TIME","representativeOfPage":true}],"publisher":{"@type":"Organization","name":"Time","url":"https://time.com/","logo":{"@type":"ImageObject","url":"https://time.com/images/logo.png","width":528,"height":156},"foundingDate":"March 3, 1923","sameAs":["https://www.facebook.com/time","https://www.instagram.com/time/?hl=en","https://twitter.com/time","https://www.pinterest.com/timemagazine"]}},{"@context":"https://schema.org","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"/section/health/","name":"Health"}},{"@type":"ListItem","position":2,"item":{"@id":"/tag/medicine/","name":"medicine"}},{"@type":"ListItem","position":3,"item":{"@id":"https://time.com/3970282/malaria-vaccine-approved/","name":"The First-Ever Malaria Vaccine Just Got a Big Break"}}]},{"@context":"https://schema.org","@type":"VideoObject","name":"Ebola Fighters in the U.S. - TIME's Person of the Year 2014","description":"Dr. Kent Brantly and other health care workers talk about surviving Ebola","thumbnailUrl":"https://cdn.jwplayer.com/v2/media/SBg4j1BY/poster.jpg?width=720","uploadDate":"2014-12-10T11:44:12.000Z","contentUrl":"https://cdn.jwplayer.com/manifests/SBg4j1BY.m3u8","embedUrl":"https://time.com/3970282/malaria-vaccine-approved/","duration":"PT6M15S","potentialAction":{"@type":"SeekToAction","target":"https://time.com/3970282/malaria-vaccine-approved/?jw_start={seek_to_second_number}","startOffset-input":"required name=seek_to_second_number"}}] ```