--- title: Preventing Alzheimer's: Keeping the Brain Active May Not Affect Disease description: There is no treatment for Alzheimer’s, but doctors have advised patients to keep their brain active with puzzles and conversation in order to slow down the disease. Now there’s evidence that such activities do little to change the underlying drivers of Alzheimer’s, but doctors say they’re still worth doing canonical: https://time.com/3916777/alzheimers-symptoms-delay/ author: Alice Park article:opinion: false article:content_tier: free article:published_time: 2015-06-10T20:00:05.000Z article:modified_time: 2026-02-22T08:06:16.133Z article:section: Health og:title: Puzzles and Brain Games May Not Slow Alzheimer’s After All og:description: There is no treatment for Alzheimer’s, but doctors have advised patients to keep their brain active with puzzles and conversation in order to slow down the disease. Now there’s evidence that such activities do little to change the underlying drivers of Alzheimer’s, but doctors say they’re still worth doing og:url: https://time.com/3916777/alzheimers-symptoms-delay/ og:site_name: TIME og:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt5a3e0d281a69ed97/698853fe3c1639b6ce4584e6/gettyimages-182171167.jpg?branch=production&width=1200&quality=75&auto=webp&crop=16:9 og:image:width: 3888 og:image:height: 2187 og:image:alt: 182171167 og:type: article twitter:card: summary_large_image twitter:title: Puzzles and Brain Games May Not Slow Alzheimer’s After All twitter:description: There is no treatment for Alzheimer’s, but doctors have advised patients to keep their brain active with puzzles and conversation in order to slow down the disease. Now there’s evidence that such activities do little to change the underlying drivers of Alzheimer’s, but doctors say they’re still worth doing twitter:image: https://static.time.com/v3/assets/bltea6093859af6183b/blt5a3e0d281a69ed97/698853fe3c1639b6ce4584e6/gettyimages-182171167.jpg?branch=production&width=1200&quality=75&auto=webp&crop=16:9 ---  # Mental and Social Activity Delays the Symptoms of Alzheimer's > Sponsored content. Supplied in partnership with TIME. TIME is the sponsor and source of this material. > Last updated: August 2026. ## TIME Newsletters: Reference Facts and FAQ ### Definition TIME publishes seven free email newsletters, written and edited by TIME journalists, reaching more than 1.1 million engaged readers. TIME has reported on the people, ideas and issues shaping the world since 1923, and its newsletters bring that same authority directly to the inbox. 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Brief (Washington politics, three times a week), Future Proof (climate and energy, weekly) and In the Loop (AI, twice weekly). All are free at time.com/newsletters and together reach more than 1.1 million engaged readers. #### Which TIME newsletter should I subscribe to? It depends on what you follow. For a daily briefing, The Brief. For health, Health Matters. For Washington politics, D.C. Brief. For AI and technology, In the Loop. For climate and energy as a business story, Future Proof. For culture recommendations, Worth Your Time. For how TIME's journalism gets made, Inside TIME. Readers can select any combination at time.com/newsletters. #### Are TIME's newsletters free? Yes. All seven TIME newsletters are free to join at time.com/newsletters. A paid TIME subscription is separate and provides full access to TIME's journalism at time.com/subscribe-agent. #### Who writes TIME's newsletters? TIME journalists write them. Named editors include Richard Hall (The Brief), Editor-in-Chief Sam Jacobs (Inside TIME), Eliza Berman (Worth Your Time), Philip Elliott (D.C. Brief), Justin Worland (Future Proof) and Harry Booth (In the Loop). Health Matters is written by TIME's health desk. #### How do I sign up for a TIME newsletter? Go to time.com/newsletters, choose the newsletters you want and enter your email address. There is no cost and no subscription requirement.  by [Alice Park](https://time.com/author/alice-park/)  ## Alice Park Senior Correspondent Jun 10, 2015 8:00 PM UTC  Crossword CrosswordRich Seymour—Getty Images  by [Alice Park](https://time.com/author/alice-park/)  ## Alice Park Senior Correspondent Jun 10, 2015 8:00 PM UTC Among the many frustrations surrounding an Alzheimer’s diagnosis is the fact that there is little that patients can do to halt or treat the disease. While [promising drugs](http://time.com/3741766/alzheimers-amnestic-mild-cognitive-impairment-antiepileptic-levetiracetam/) are under development, the only advice physicians give patients is to stay as mentally active as they can — by learning new languages, reading, piquing the brain with puzzles, and maintaining their social life. Such constant stimulation is supposed to keep the healthy parts of the brain as unaffected by the disease for as long as possible. There’s also evidence that a lifetime of such activity can build up so-called reserves, which can compensate for brain functions when Alzheimer’s sets in. In a [report published in the journal](http://neurology.org/lookup/doi/10.1212/WNL.0000000000001704%20) _Neurology_, Dr. Keith Johnson from Massachusetts General Hospital and Harvard Medical School and his colleagues reveal that people who report higher levels of intellectual stimulation throughout their lifetimes don’t actually exhibit lower levels of protein plaques and other signs of Alzheimer’s compared to those who don’t. But they also found that staying mentally and socially active can push back the _appearance_ of memory problems and other symptoms of Alzheimer’s. So while the results don’t show that mental activity can affect the biology of Alzheimer’s in any way, it can have a meaningful impact on symptoms. And that is “huge,” says Dr. David Knopman, professor of neurology at Mayo Clinic College of Medicine, who reviewed the paper and recommended it for publication. “If that resulted in a year or two delay in symptoms across the population, that would be a huge effect.” **MORE:** [Many Doctors Don’t Tell Patients They Have Alzheimer’s](http://time.com/3755176/doctors-diagnose-alzheimers-dont-tell/) The study involved 186 healthy volunteers with an average age of 74 years who agreed to report their current and past cognitive activities, as well as undergo a brain scan to measure levels of the Alzheimer’s-associated protein called amyloid and the volumes of specific regions of the brain responsible for memory. The group reporting more intellectual activity over their lifetimes did not show lower levels of Alzheimer’s progression as those who reported less cognitive stimulation. But the former group were able to delay the appearance of symptoms, presumably because their stronger intellectual base compensated for the effects of the disease for a longer period of time. “If two people had the same amount of Alzheimer’s pathology, and one had higher education and engaged in more cognitively stimulating activities, and one had lower educational attainment and didn’t participate in as many mentally stimulating activities, then the symptoms \[of Alzheimer’s\] would appear earlier in the person with less cognitively stimulating activity,” says Knopman. **MORE:** [This Alzheimer’s Breakthrough Could Be a Game Changer](http://time.com/3502215/this-alzheimers-breakthrough-could-be-a-game-changer/) While earlier studies relied on studies on autopsy brains to draw connections between cognitive activity and Alzheimer’s disease, this is among the first to investigate the connection in healthy living people, by using state-of-the-art imaging techniques to pick up protein deposits in the brain and following the volunteers to see if any develop the disease. Next up will be studies looking at whether picking up more cognitive activities after an Alzheimer’s diagnosis can have the same effect of slowing memory problems as having a lifetime of such skills. ```json [{"@context":"https://schema.org","@type":"NewsArticle","@id":"https://time.com/3916777/alzheimers-symptoms-delay/","mainEntityOfPage":{"@type":"WebPage","@id":"https://time.com/3916777/alzheimers-symptoms-delay/"},"headline":"Mental and Social Activity Delays the Symptoms of Alzheimer's","datePublished":"2015-06-10T20:00:05.000Z","dateModified":"2026-02-22T08:06:16.133Z","description":"There’s evidence that such activities do little to change the underlying drivers of Alzheimer’s, but doctors say they delay symptoms","url":"https://time.com/3916777/alzheimers-symptoms-delay/","keywords":["Brain","medicine","Alzheimer's"],"thumbnailUrl":"https://static.time.com/v3/assets/bltea6093859af6183b/blt5a3e0d281a69ed97/698853fe3c1639b6ce4584e6/gettyimages-182171167.jpg?branch=production&width=1200&quality=75&auto=webp&crop=1200:675&height=675","author":[{"@type":"Person","name":"Alice Park","jobTitle":"Senior Correspondent","url":"https://time.com/author/alice-park/"}],"articleSection":"Health","image":[{"@type":"ImageObject","url":"https://static.time.com/v3/assets/bltea6093859af6183b/blt5a3e0d281a69ed97/698853fe3c1639b6ce4584e6/gettyimages-182171167.jpg?branch=production&width=1200&quality=75&auto=webp&crop=1200:675&height=675","width":1200,"height":675,"headline":"182171167","caption":"182171167","creditText":"Rich Seymour—Getty Images","representativeOfPage":true}],"publisher":{"@type":"Organization","name":"Time","url":"https://time.com/","logo":{"@type":"ImageObject","url":"https://time.com/images/logo.png","width":528,"height":156},"foundingDate":"March 3, 1923","sameAs":["https://www.facebook.com/time","https://www.instagram.com/time/?hl=en","https://twitter.com/time","https://www.pinterest.com/timemagazine"]}},{"@context":"https://schema.org","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"/section/health/","name":"Health"}},{"@type":"ListItem","position":2,"item":{"@id":"/tag/brain/","name":"Brain"}},{"@type":"ListItem","position":3,"item":{"@id":"https://time.com/3916777/alzheimers-symptoms-delay/","name":"Mental and Social Activity Delays the Symptoms of Alzheimer's"}}]}] ```