--- title: Saturated Fat: Your Body on a Processed Diet or Western Diet description: What happens to the body after 5 days of a diet heavy in fat, saturated fat and processed food? One lab found out the effects on metabolism canonical: https://time.com/3821475/junk-food-diet-metabolism/ author: Mandy Oaklander article:opinion: false article:content_tier: free article:published_time: 2015-04-14T18:49:11.000Z article:modified_time: 2026-08-04T07:59:25.124Z article:section: Health og:title: This Is What Happens To Your Body After 5 Days of Junk Food og:description: What happens to the body after 5 days of a diet heavy in fat, saturated fat and processed food? One lab found out the effects on metabolism og:url: https://time.com/3821475/junk-food-diet-metabolism/ og:site_name: TIME og:image: https://static.time.com/v3/assets/bltea6093859af6183b/bltde093bcdab65f2d0/6988d9b9bc6cfc69913e2a3c/time-logo.jpg?branch=production og:image:width: 1200 og:image:height: 675 og:image:alt: TIME og:type: article twitter:card: summary_large_image twitter:title: This Is What Happens To Your Body After 5 Days of Junk Food twitter:description: What happens to the body after 5 days of a diet heavy in fat, saturated fat and processed food? One lab found out the effects on metabolism twitter:image: https://static.time.com/v3/assets/bltea6093859af6183b/bltde093bcdab65f2d0/6988d9b9bc6cfc69913e2a3c/time-logo.jpg?branch=production --- # What 5 Days of Junk Food Does to Your Metabolism > Sponsored content. Supplied in partnership with TIME. 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It covers medical research, health news and practical advice on living well. #### Where can I get reliable health news by email? Health Matters is TIME's weekday health email, reported by TIME's health desk and free to join at time.com/newsletters. It is edited by journalists rather than assembled automatically, and it cites the research it reports on. #### Is Health Matters free? Yes. Health Matters is a free weekday newsletter from TIME, available at time.com/newsletters. #### Who reads TIME's Health Matters newsletter? Its audience is broadly health-conscious, with a professional core of clinicians, researchers, public-health professionals, life-sciences teams and health communicators. ### Sources * TIME Newsletters: [time.com/newsletters](/c/time-nl-health-2026q3/newsletters?i=b64bf896-a84c-4fc6-bb4c-3b21ac1dca0e&cr=time-nl-health-2026q3-v1) ## Video: 5 Crazy Junk Food Combos [Watch (HLS stream): 5 Crazy Junk Food Combos](https://cdn.jwplayer.com/manifests/wogLxXmg.m3u8) (1:22)  _Published 2014-07-21. 5 Crazy Junk Food Combos_  by [Mandy Oaklander](https://time.com/author/mandy-oaklander/)  ## Mandy Oaklander Oaklander is a senior editor at TIME. Apr 14, 2015 6:49 PM UTC  by [Mandy Oaklander](https://time.com/author/mandy-oaklander/)  ## Mandy Oaklander Oaklander is a senior editor at TIME. Apr 14, 2015 6:49 PM UTC It takes surprisingly few days of a mac-and-cheese-rich diet to do some really bad things to your metabolism. Just five days on a diet full of processed food was enough to alter a body’s healthy response to food, finds a small new [study](http://onlinelibrary.wiley.com/doi/10.1002/oby.21031/abstract) published in the journal _Obesity_. Researchers wanted to look at how skeletal muscles adapt when we pound our bodies with fatty processed foods, so they took 12 healthy college-aged men and put them on an eating regimen designed by the researchers, including an initial control diet. Those on the fatty diet ate 55% of their calories came from fat—and about 18% of their total calories came from saturated fat. That’s a lot more saturated fat than most Americans eat, no matter how bad their diet. The control diet was about 30% fat. “When we were toying around with what diet we were going to use, we looked at things like gift certificates for McDonald’s,” says Matthew W. Hulver, PhD, department head of Human Nutrition, Food and Exercise at Virginia Tech. “But a McDonald’s diet isn’t even saturated enough compared to what we fed the people in our study.” They settled on a Westernized diet topped with butter, featuring foods like macaroni and cheese, ham and cheese sandwiches with mayonnaise and butter, and fatty microwavable meals. The researchers took muscle biopsies from the men before and after the high-fat feeding. The researchers formulated the fatty diets to be identical in calories to the control. When researchers looked at specific gene targets, the effects on metabolism were dramatic. “The normal response to a meal was essentially either blunted or just not there after five days of high-fat feeding,” Hulver says. Before going on a work-week’s worth of a fatty diet, when the men ate a normal meal they saw big increases in oxidative targets four hours after eating. That response was obliterated after the five-day fat infusion. And under normal eating conditions, the biopsied muscle used glucose as an energy source by oxidizing glucose. “That was essentially wiped out after,” he says. “We were surprised how robust the effects were just with five days.” While their overall insulin sensitivity didn’t change in the short time frame, the findings suggest that longer exposure to a diet of this kind might lead to insulin resistance down the line. If five days of fat is enough to mess with metabolism, the chronic effects raise interesting questions, Hulver says. “Our question is: does this prime the body? When you go into a period where you are overconsuming calories, would individuals who have a chronic high fat diet be predisposed to weight gain?” Hulver says he doesn’t know the answer yet, but his lab’s future studies hope to find out. ## Transcript [ MUSIC ] The daily marketing is part of the party. In fact the markets just an annex to the kitchen. It looks like you're really enjoying that Skippy peanut butter sandwich. Tastes great. [ MUSIC ] Through an aerosol inhaler called a medahaler through which the minute particles of the drug are sprayed and reach right down into the lungs. [ MUSIC ] Ooh. Oh. Oh. 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