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Obese mouse and normal mouse used for biomedical research
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This New Drug Turns 'Bad' White Fat Into 'Good' Brown Fat

Mar 09, 2015
TIME Health
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Scientists claim they have found an experimental drug that turns “bad” white fat cells into “good” brown ones.

Known as GC-1, the drug speeds up metabolism, or the burning off of fat cells, reports Science Daily. Researchers found it caused weight loss in fat mice.

"GC-1 dramatically increases the metabolic rate, essentially converting white fat, which stores excess calories and is associated with obesity and metabolic disease, into a fat like calorie-burning brown fat," said study author Kevin Phillips of the Houston Methodist Research Institute.

Until recently, scientists thought only animals and human infants had these energy-burning “good” brown-fat cells.

“It is now clear that human adults do have brown fat, but appear to lose its calorie-burning activity over time," Phillips added.

He calls white fat a “metabolic villain” when you have too much of it, whereas people with more brown fat have a reduced risk of obesity and diabetes.

GC-1 works by activating receptors for the thyroid hormone, which help regulate how your body turns food into energy.

Phillips’ team tested the drug on hundreds of mice who were genetically obese or who had diet-induced obesity. They found genetically obese mice lost weight and nearly 50% of their fat mass in two weeks. Diet-induced obese mice also showed improvements.

The drug was also tested on white fat cells grown in a lab, and researchers say they found evidence that the drug turned white fat into the brown variety.

Phillips hopes the drug, which has not yet been tested on humans, has the potential to treat obesity and metabolic disease.

The results of the study will be presented at the Endocrine Society's 97th annual meeting in San Diego on Friday.

[Science Daily]

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