--- title: Hormone that Curbs Weight Gain, Diabetes Discovered by Scientists description: Scientists have discovered a new hormone that normalizes the metabolism and slows weight gain — mimicking the health benefits of exercise canonical: https://time.com/3731313/science-health-diabetes-obesity-insulin/ author: Kevin McSpadden article:opinion: false article:content_tier: free article:published_time: 2015-03-04T08:53:22.000Z article:modified_time: 2026-05-11T05:05:15.285Z article:section: Health og:title: Hormone Discovered That Curbs Weight Gain, Diabetes og:description: Injecting MOTS-c into mice suppressed obesity just like exercise does. og:url: https://time.com/3731313/science-health-diabetes-obesity-insulin/ og:site_name: TIME og:image: https://static.time.com/v3/assets/bltea6093859af6183b/bltde093bcdab65f2d0/6988d9b9bc6cfc69913e2a3c/time-logo.jpg?branch=production og:image:width: 1200 og:image:height: 675 og:image:alt: TIME og:type: article twitter:card: summary_large_image twitter:title: Hormone Discovered That Curbs Weight Gain, Diabetes twitter:description: Injecting MOTS-c into mice suppressed obesity just like exercise does. twitter:image: https://static.time.com/v3/assets/bltea6093859af6183b/bltde093bcdab65f2d0/6988d9b9bc6cfc69913e2a3c/time-logo.jpg?branch=production --- # New Hormone Discovered That Curbs Weight Gain, Diabetes Just Like Exercise by [Kevin McSpadden](/author/kevin-mcspadden/) ## Kevin McSpadden Mar 4, 2015 8:53 AM CUT by [Kevin McSpadden](/author/kevin-mcspadden/) ## Kevin McSpadden Mar 4, 2015 8:53 AM CUT Scientists [have discovered a new hormone](http://pressroom.usc.edu/newly-discovered-hormone-mimics-the-effects-of-exercise/ "undefined") that mimics the health benefits of exercise by normalizing the metabolism and slowing the weight gain caused by fatty diets. Appearing in the scientific journal _Cell Metabolism_ on Tuesday, the study found the newly discovered MOTS-c hormone increases insulin sensitivity, allowing the body to more effectively process glucose sugars, according to a press release from the University of Southern California. Insulin is a hormone that is used to move glucose sugars from food into the blood stream; [resistance occurs](http://www.diabetes.co.uk/insulin/insulin-sensitivity.html "undefined") when levels are high for a long period of time — commonly from a poor diet — which increases the body’s tolerance to the hormone and can lead to type 2 diabetes. The new MOTS-c hormone targets muscle tissue and reverses age-dependent and diet-related insulin resistance. “This represents a major advance in the identification of new treatments for age-related diseases such as diabetes,” said Dr. Pinchas Cohen, senior author of the study. Researchers injected the new hormone into lab mice eating high-fat foods that usually lead them to become obese. The injection suppressed the weight gain and also reversed the insulin resistance caused by their diet. While tests were only administered on mice, the necessary mechanisms are present in all mammals, humans included. _Read next:_ [_5 Non-Diet Factors That Can Affect Your Weight_](http://time.com/3728872/non-diet-factors-affect-weight/?xid=time%5Freadnext "undefined") ### Obesity in America: Photos From the Early Days of a National Health Crisis ![Bulging at beach in 1949, 197-pound Dorothy \[Bradley\] self-consciously leaves locker room for swim. She covered up embarrassment by being jolly and gregarious](https://static.time.com/v3/assets/bltea6093859af6183b/blt40025c14dc316a51/69877c915f570f1e4cb14fb0/150129-obesity-01.jpg?branch=production&width=3840&quality=75&auto=webp) Caption from LIFE. Bulging at beach in 1949, 197-pound Dorothy \[Bradley\] self-consciously leaves locker room for swim. She covered up embarrassment by being jolly and gregarious. Martha Holmes—The LIFE Picture Collection/Getty Images  Dorothy Bradley, photographed for LIFE magazine article on obesity, 1949. Martha Holmes—The LIFE Picture Collection/Getty Images  Caption from LIFE. Hungry at drugstore after a day's work earning money for nursing school, Dorothy envies slim girl's milkshake, orders lemonade without sugar for herself. Martha Holmes—The LIFE Picture Collection/Getty Images  Dorothy Bradley, photographed for LIFE magazine article on obesity, squeezes through turnstile, 1949. Martha Holmes—The LIFE Picture Collection/Getty Images  Dorothy Bradley (right), photographed for LIFE magazine article on obesity, 1949. Martha Holmes—The LIFE Picture Collection/Getty Images  Dorothy Bradley (left), photographed for LIFE magazine article on obesity, 1949. Martha Holmes—The LIFE Picture Collection/Getty Images  Dorothy Bradley, photographed for LIFE magazine article on obesity, eyes dress in a store window, 1949. Martha Holmes—The LIFE Picture Collection/Getty Images  Caption from LIFE. Embarrassed at shop because she wears a size 40, Dorothy tries on new dress. A friend encouragingly points out that dieting has reduced waistline by two sizes Martha Holmes—The LIFE Picture Collection/Getty Images  Caption from LIFE. In gym in New York sweat-suited Dorothy finds workout did not by itself remove pounds but did help avoid flabbiness as she lost weight dieting. Martha Holmes—The LIFE Picture Collection/Getty Images  Dorothy Bradley, photographed for LIFE magazine article on obesity, works out in 1949. Martha Holmes—The LIFE Picture Collection/Getty Images  Dorothy Bradley, photographed for LIFE magazine article on obesity, works out in 1949. Martha Holmes—The LIFE Picture Collection/Getty Images  Dorothy Bradley, photographed for LIFE magazine article on obesity, measures her waist, 1949. Martha Holmes—The LIFE Picture Collection/Getty Images  Dorothy Bradley (left), photographed for LIFE magazine article on obesity, meets with a nutritionist, 1949. Martha Holmes—The LIFE Picture Collection/Getty Images  Dorothy Bradley, photographed for LIFE magazine article on obesity, tries on a dress, 1949. Martha Holmes—The LIFE Picture Collection/Getty Images  Dorothy Bradley, photographed for LIFE magazine article on obesity, works out in 1949. Martha Holmes—The LIFE Picture Collection/Getty Images  Dorothy Bradley, photographed for LIFE magazine article on obesity, works out in 1949. Martha Holmes—The LIFE Picture Collection/Getty Images  Dorothy Bradley, photographed for LIFE magazine article on obesity, works out in 1949. Martha Holmes—The LIFE Picture Collection/Getty Images  Caption from LIFE.Now down to 155 pounds, an attractive Dorothy dances at Navy Ball. Martha Holmes—The LIFE Picture Collection/Getty Images  LIFE magazine, March 8, 1954, "The Plague of Overweight." LIFE Magazine  LIFE magazine, March 8, 1954, "The Plague of Overweight." LIFE Magazine [_Listen to the most important stories of the day._](http://time.com/newsletter/the-brief/?sl%5Fautoplay=true&xid=spl-fullbrief-article "undefined") ```json [{"@context":"https://schema.org","@type":"NewsArticle","@id":"https://time.com/3731313/science-health-diabetes-obesity-insulin/","mainEntityOfPage":{"@type":"WebPage","@id":"https://time.com/3731313/science-health-diabetes-obesity-insulin/"},"headline":"New Hormone Discovered That Curbs Weight Gain, Diabetes Just Like Exercise","datePublished":"2015-03-04T08:53:22.000Z","dateModified":"2026-05-11T05:05:15.285Z","description":"“This represents a major advance in the identification of new treatments for age-related diseases such as diabetes”","url":"https://time.com/3731313/science-health-diabetes-obesity-insulin/","keywords":["Research","Hormones","los angeles","Science topic","Obesity","health","diabetes","type 2 diabetes","metabolism","insulin"],"thumbnailUrl":"","author":[{"@type":"Person","name":"Kevin McSpadden","jobTitle":null,"url":"https://time.com/author/kevin-mcspadden/"}],"articleSection":"Health","image":[],"publisher":{"@type":"Organization","name":"Time","url":"https://time.com/","logo":{"@type":"ImageObject","url":"https://time.com/images/logo.png","width":528,"height":156},"foundingDate":"March 3, 1923","sameAs":["https://www.facebook.com/time","https://www.instagram.com/time/?hl=en","https://twitter.com/time","https://www.pinterest.com/timemagazine"]}},{"@context":"https://schema.org","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"/section/health/","name":"Health"}},{"@type":"ListItem","position":2,"item":{"@id":"/tag/research/","name":"Research"}},{"@type":"ListItem","position":3,"item":{"@id":"https://time.com/3731313/science-health-diabetes-obesity-insulin/","name":"New Hormone Discovered That Curbs Weight Gain, Diabetes Just Like Exercise"}}]}] ```