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title: Why Pot Causes the Munchies
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![](https://static.time.com/v3/assets/bltea6093859af6183b/blt28bb393dfae0e916/69877fd4a988ca27ed6ac887/pizza.jpg?branch=production&width=1200&quality=75&auto=webp&crop=16:9)


# Why Smoking Pot Brings On the 'Munchies'

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<!-- video src="https://cdn.jwplayer.com/manifests/50vzabYY.m3u8" -->
## Video: That Time Has Come: Here's The First Marijuana Ad

[Watch (HLS stream): That Time Has Come: Here's The First Marijuana Ad](https://cdn.jwplayer.com/manifests/50vzabYY.m3u8) (1:35)

![That Time Has Come: Here's The First Marijuana Ad](https://cdn.jwplayer.com/v2/media/50vzabYY/poster.jpg?width=720)

_Published 2014-03-04. That time has come. The first marijuana commercial is due to air on major networks, including Fox, CNN, Comedy Central, and the Food Network._


by 

[Alexandra Sifferlin](https://time.com/author/alexandra-sifferlin/)


## Alexandra Sifferlin


Feb 18, 2015 8:18 PM UTC

![a stock photograph of pizza](https://static.time.com/v3/assets/bltea6093859af6183b/blt28bb393dfae0e916/69877fd4a988ca27ed6ac887/pizza.jpg?branch=production&width=1200&quality=75&auto=webp&crop=3:2)

Weekend diet

Weekend diet Getty Images

by 

[Alexandra Sifferlin](https://time.com/author/alexandra-sifferlin/)


## Alexandra Sifferlin


Feb 18, 2015 8:18 PM UTC

Wherever marijuana is smoked, the consumption of snacks usually follows — and a [new study](http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14260.html) suggests that’s because pot causes changes in brain circuitry that make you hungry.

Pot heads and scientists alike have long known that marijuana can make a person crave food, a phenomena known colloquially as the munchies. But the evidence is still cloudy when it comes to why this happens. So a team of Yale researchers set off to figure it out.

In a new study published in the journal _Nature_, the researchers discovered that cannabinoids from marijuana actually interfere with signaling in the brain that causes the body to feel hungry when it should be feeling full. To do so, they looked at the brains of high mice.

The researchers observed that the neurons in the mice brains that make them feel sated, called POMCs, were activated in those who were given a chemical to mimic marijuana in the brain. At first, it didn’t make any sense. If the neuron in the brain that inhibits hunger is activated, then shouldn’t the mice be much less hungry? Not hungrier?

What the team discovered was that the cannabinoids interfere with the chemical POMCs’ release — so that when the mice were “sober,” the neurons released a satiety chemical. But when the mice were “high,” their neurons released a chemical that spurs appetite.


“It’s like pressing a car’s brakes and accelerating instead,” said study author Tamas Horvath [in a statement](http://www.eurekalert.org/pub%5Freleases/2015-02/yu-mtm021315.php). “We were surprised to find that the neurons we thought were responsible for shutting down eating, were suddenly being activated and promoting hunger, even when you are full. It fools the brain’s central feeding system.”

The new findings join the many working theories looking at why marijuana causes hunger. A [study](http://time.com/6474/blame-your-sense-of-smell-for-why-you-get-the-munchies/) from last February, for example, suggests that the THC in marijuana activates smell receptors which causes hunger. The new results are still preliminary and require further research. For now, the jury is still out.

_Read next:_ [_This Event Will Teach Businesspeople How to Buy Pot_](http://time.com/3714299/marijuana-investment-and-private-retreat/?xid=time%5Freadnext)


[_Listen to the most important stories of the day._](http://time.com/newsletter/the-brief/?sl%5Fautoplay=true&xid=spl-fullbrief-article)


## Transcript

The time has come. The first marijuana commercial is due to air on major networks including Fox, CNN, Comedy Central and the Food Network. A company called the Marijuana Doctors, which connects medical marijuana patients with doctors, who can prescribe the drug. Claims that it's airing the first ever marijuana commercial on a major network. The ad draws a parallel between a shady street dealer trying to push unsafe sushi to unsuspecting buyers. And medical marijuana patients having to buy their medication on the street in a similar fashion. Take a look. Yo. You want sushi? I got sushi, I got the best sushi.

This area is dry man, you know that, I know that, ain't nobody selling but me. I got tuna. I got salmon. I got sweet shrimp. I got the finest sashimi this area has seen in years. You need me and I need you. Let's make this work. You buy some sashimi, I'll throw in some rice paper man, totally free, gratis. I got everything. Even California rolls, baby. You wouldn't buy your sushi from this guy. So why would you buy your marijuana from him? Marijuanadoctors. com is the only service that connects patients with real doctors for medical marijuana recommendations. Simple, confidential, safe. Visit marijuanadoctors.

com or call 1 866 996 9333. That's marijuanadoctors. com, 1 866 996 9333. Book your appointment today.

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