Caitlyn JennerFrom "Person of the Year." December 21, 2015 issue.Sebastian Kim for TIME
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May 23, 2015, Austin, Indiana. Tiffany Turner poses for a portrait at her home. Tiffany Turner became addicted to Opana after the death of her husband and a long time pain killer problem. After losing custody of her children she quit drugs a month ago, and is now volunteering at the needle exchange and fighting to regain custody of her kids. Austin, Indiana has recently been rocked by the diagnosis of over 160 HIV cases in the small community. The majority of these cases have been found in users of Opana, a prescription pain killer which can be abused intravenously and is considered highly addictive. The city has recently opened a needle exchange program to provide clean syringes to the drug users and help to contain the outbreak. (Natalie Keyssar)
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SCOTT KELLY IN THE SOYUZ CAPSULE TPK2.JPG
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Caitlyn JennerFrom "Person of the Year." December 21, 2015 issue.
Sebastian Kim for TIME
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TIME's Best Portraits of 2015

Dec 18, 2015

When photographer Mark Seliger walked into a room at the Bush Center in Dallas this past July, he faced George W. Bush and Bill Clinton, two former U.S. Presidents who had just announced a new educational joint venture between their respective libraries. The unprecedented photoshoot — Seliger had photographed presidents before, but never two at the same time — is just one of the many TIME commissioned this year.

The subjects of those portraits include Republican frontrunner Donald Trump, new Late Show host Stephen Colbert, actors like Tom Hanks and Sandra Bullock, astronaut Scott Kelly and many more of the year's most influential leaders in politics, entertainment, business, sciences and the arts. And they weren't all celebrities: TIME also photographed the women who fight the Islamic State in Syria and the families who continue to flee the group's regime of terror.

In this chronological gallery, TIME's photo department presents its selection of the best portraits it commissioned in 2015.

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