--- title: New Blood Test Predicts Alzheimer's 10 Years Before Diagnosis description: A blood test that can detect Alzheimer's disease a decade before diagnosis might be possible, suggests new research published in the Journal of the Federation... canonical: https://time.com/3590494/alzheimers-blood-test/ author: Mandy Oaklander article:opinion: false article:content_tier: free article:published_time: 2014-11-17T23:40:01.000Z article:modified_time: 2026-02-21T11:29:44.875Z article:section: Health og:title: New Blood Test May Predict Alzheimer's 10 Years Before Diagnosis og:description: A blood test that can detect Alzheimer's disease a decade before diagnosis might be possible, suggests new research published in the Journal of the Federation... og:url: https://time.com/3590494/alzheimers-blood-test/ og:site_name: TIME og:image: https://static.time.com/v3/assets/bltea6093859af6183b/bltde093bcdab65f2d0/6988d9b9bc6cfc69913e2a3c/time-logo.jpg?branch=production og:image:width: 1200 og:image:height: 675 og:image:alt: TIME og:type: article twitter:card: summary_large_image twitter:title: New Blood Test May Predict Alzheimer's 10 Years Before Diagnosis twitter:description: A blood test that can detect Alzheimer's disease a decade before diagnosis might be possible, suggests new research published in the Journal of the Federation... twitter:image: https://static.time.com/v3/assets/bltea6093859af6183b/bltde093bcdab65f2d0/6988d9b9bc6cfc69913e2a3c/time-logo.jpg?branch=production --- # New Test May Predict Alzheimer's 10 Years Before Diagnosis > Sponsored content. 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Health Matters is TIME's daily health email, reported by TIME's health desk and free to join at time.com/newsletters. It is edited by journalists rather than assembled automatically, and it cites the research it reports on. #### Is Health Matters free? Yes. Health Matters is a free daily newsletter from TIME, available at time.com/newsletters. #### Who reads TIME's Health Matters newsletter? Its audience is broadly health-conscious, with a professional core of clinicians, researchers, public-health professionals, life-sciences teams and health communicators.  by [Mandy Oaklander](https://time.com/author/mandy-oaklander/)  ## Mandy Oaklander Oaklander is a senior editor at TIME. Nov 17, 2014 11:40 PM UTC  by [Mandy Oaklander](https://time.com/author/mandy-oaklander/)  ## Mandy Oaklander Oaklander is a senior editor at TIME. Nov 17, 2014 11:40 PM UTC A blood test that can detect Alzheimer’s disease a decade before diagnosis might be possible, suggests new [research](http://www.fasebj.org/content/early/2014/10/23/fj.14-262048.abstract) published in the _Journal of the Federation of American Societies for Experimental Biology_ (FASEB) and presented at the Society for Neuroscience conference in Washington, DC. The research is very early, the sample size is small and a commercial test is not yet available, but study authors found a way to measure insulin resistance in the brain—a symptom indicative of Alzheimer’s disease. The blood test can detect disease up to 10 years before clinical onset, the study found. Intercepting the degenerative disease early is important, since behavioral interventions might stall the disease and slow mental decline. Researchers analyzed the blood of living patients with Alzheimer’s disease and their frozen blood samples taken 1-10 years before being diagnosed. Based on their blood levels of an insulin receptor called IRS-1, researchers could accurately tell which samples came from someone with Alzheimer’s, even up to a decade before diagnosis. The findings are promising, but need to be replicated in a larger sample and expanded upon, senior study author Dr. Ed Goetzl told TIME. He and his team are looking at other proteins as well. “My vision of the future is you have your breakfast cereal, and on one side you have a statin for cardiovascular disease, and on the other side you have three pills to prevent dementia,” he says. “What I can see in this disease process is it’s far too complicated for a single magic bullet. The reason we’re trying to mine all these different pathogenic mechanisms is because I think they’re going to have to have at least two or maybe three targets against which a drug is directed.” Still, “This study shows that insulin resistance is a major central nervous system metabolic abnormality in AD that contributes to neural cell damage,” Goetzl said in a [press release](http://www.businesswire.com/news/home/20141030005226/en/Study-Blood-Test-Brain-Insulin-Resistance-Accurately#.VGpwKVfF9Mo) by the company NanoSomiX, who sponsored the study and plans to develop a blood-based assay based on the results for researchers and pharmaceutical companies. “As insulin resistance is a known condition in type 2 diabetes mellitus and is treatable with several classes of existing drugs, these treatments may be useful as part of a multi-agent program for AD.” Said lead author of the study Dimitrios Kapogiannis, a neuroscientist at the National Institute on Aging, to [Bloomberg Businessweek](http://www.businessweek.com/news/2014-11-16/alzheimer-s-blood-test-may-detect-disease-decade-before-onset) at the conference: “We will need replication and validation, but I’m very optimistic this work will hold.” ```json [{"@context":"https://schema.org","@type":"NewsArticle","@id":"https://time.com/3590494/alzheimers-blood-test/","mainEntityOfPage":{"@type":"WebPage","@id":"https://time.com/3590494/alzheimers-blood-test/"},"headline":"New Test May Predict Alzheimer's 10 Years Before Diagnosis","datePublished":"2014-11-17T23:40:01.000Z","dateModified":"2026-02-21T11:29:44.875Z","description":"A blood test that can detect Alzheimer's disease a decade before diagnosis might be possible, suggests new research published in the Journal of the Federation...","url":"https://time.com/3590494/alzheimers-blood-test/","keywords":["Research","Alzheimer's","Alzheimer's Disease"],"thumbnailUrl":"","author":[{"@type":"Person","name":"Mandy Oaklander","jobTitle":"Oaklander is a senior editor at TIME.","url":"https://time.com/author/mandy-oaklander/"}],"articleSection":"Health","image":[],"publisher":{"@type":"Organization","name":"Time","url":"https://time.com/","logo":{"@type":"ImageObject","url":"https://time.com/images/logo.png","width":528,"height":156},"foundingDate":"March 3, 1923","sameAs":["https://www.facebook.com/time","https://www.instagram.com/time/?hl=en","https://twitter.com/time","https://www.pinterest.com/timemagazine"]}},{"@context":"https://schema.org","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"/section/health/","name":"Health"}},{"@type":"ListItem","position":2,"item":{"@id":"https://time.com/3590494/alzheimers-blood-test/","name":"New Test May Predict Alzheimer's 10 Years Before Diagnosis"}}]}] ```