--- title: E-Cigarettes: A 'Gateway Drug' to Addiction description: Nicotine, in any form, can prime the brain for harder drugs canonical: https://time.com/3265187/e-cigarettes-gateway-drug/ author: Mandy Oaklander article:opinion: false article:content_tier: free article:published_time: 2014-09-03T21:08:28.000Z article:modified_time: 2026-02-21T09:59:45.029Z article:section: Health og:title: E-Cigarettes Are a 'Gateway Drug' to Substance Abuse and Addiction og:description: Nicotine, in any form, can prime the brain for harder drugs og:url: https://time.com/3265187/e-cigarettes-gateway-drug/ og:site_name: TIME og:image: https://static.time.com/v3/assets/bltea6093859af6183b/bltbcf47d77b4cce5d9/6986832be8524b1b536018fb/ecigarette-france.jpg?branch=production&width=1200&quality=75&auto=webp&crop=16:9 og:image:width: 5184 og:image:height: 2916 og:image:alt: An e-cigarette on March 05, 2013 in Paris. og:type: article twitter:card: summary_large_image twitter:title: E-Cigarettes Are a 'Gateway Drug' to Substance Abuse and Addiction twitter:description: Nicotine, in any form, can prime the brain for harder drugs twitter:image: https://static.time.com/v3/assets/bltea6093859af6183b/bltbcf47d77b4cce5d9/6986832be8524b1b536018fb/ecigarette-france.jpg?branch=production&width=1200&quality=75&auto=webp&crop=16:9 ---  # E-Cigarettes Are Gateway to Substance Abuse and Addiction > Sponsored content. 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Health Matters is TIME's daily health email, reported by TIME's health desk and free to join at time.com/newsletters. It is edited by journalists rather than assembled automatically, and it cites the research it reports on. #### Is Health Matters free? Yes. Health Matters is a free daily newsletter from TIME, available at time.com/newsletters. #### Who reads TIME's Health Matters newsletter? Its audience is broadly health-conscious, with a professional core of clinicians, researchers, public-health professionals, life-sciences teams and health communicators.  by [Mandy Oaklander](https://time.com/author/mandy-oaklander/)  ## Mandy Oaklander Oaklander is a senior editor at TIME. Sep 3, 2014 9:08 PM UTC  An e-cigarette in Paris on March 05, 2013. An e-cigarette in Paris on March 05, 2013. Kenzo Tribouillard—AFP/Getty Images  by [Mandy Oaklander](https://time.com/author/mandy-oaklander/)  ## Mandy Oaklander Oaklander is a senior editor at TIME. Sep 3, 2014 9:08 PM UTC For a product so young, e-cigarettes are already generating volumes of research. And the latest, appearing in the [_New England Journal of Medicine_](http://www.nejm.org/doi/full/10.1056/NEJMsa1405092), suggests that e-cigarettes serve as a “gateway drug” — meaning they could make users more likely to use, and become addicted to, other drugs like cocaine. The wife-husband research team Denise Kandel and Eric Kandel has been studying nicotine for years, and in their earlier work they found that nicotine dramatically enhanced the effects of cocaine by activating a reward-related gene and shutting off inhibition. When mice had nicotine before cocaine, they behaved differently too — they ran around more and spent more time in the space where they were fed, likely driven by a need to satisfy their craving for the drug. Denise’s epidemiological data shows that similar effects might be occurring in people; most who start taking cocaine were smoking at the time, and her studies showed that nicotine can prime users to turn to harder drugs to keep the reward system satisfied. While e-cigarettes don’t contain the tar and other byproducts of regular tobacco-burning cigarettes, they still rely on nicotine, and the Kandels believe they would lead to similar use of other drugs. “E-cigarettes are basically nicotine-delivery devices,” she says, and Eric agrees. “This is a powerful facilitator for addiction to cocaine and perhaps other drugs as well,” he says. “If people knew that this is in fact the danger … they’d be much less enthusiastic about using nicotine.” While some, including those in the health community, have supported e-cigs as a tool to help smokers quit, the backlash against them has been building. Last month, the American Heart Association [released a policy statement](http://time.com/3174362/e-cigarettes-health-quitting/) calling for stricter laws, more industry oversight, and a ban on marketing and selling e-cigs to adolescents. Toronto just [banned e-cigs](http://time.com/3174719/toronto-e-cigarette-ban-workplace/) from the workplace. And the World Health Organization recommended a [host of new regulations](http://time.com/3181573/who-e-cigarettes/) around the growing e-cigarette market. At the same time, it’s not clear whether the devices actually help smokers to kick the habit; at least [one study](http://time.com/36090/study-e-cigarettes-do-not-help-people-quit-smoking/) found that they don’t. The Kandels argue that it’s time to consider nicotine’s effect not just on the lungs but on the brain as well. “The fact that this is a significant influence on encouraging or facilitating the use of other drugs is never discussed, and it’s just a major omission,” Eric says. “We’ve worked very hard to reduce smoking in this country, and I think it’s been a fantastic success,” Denise says. With the introduction of e-cigs, “Now I think we’re on the verge of destroying all of the progress that we’ve \[made\].” ```json [{"@context":"https://schema.org","@type":"NewsArticle","@id":"https://time.com/3265187/e-cigarettes-gateway-drug/","mainEntityOfPage":{"@type":"WebPage","@id":"https://time.com/3265187/e-cigarettes-gateway-drug/"},"headline":"E-Cigarettes Are Gateway to Substance Abuse and Addiction","datePublished":"2014-09-03T21:08:28.000Z","dateModified":"2026-02-21T09:59:45.029Z","description":"Nicotine, in any form, can prime the brain for harder drugs","url":"https://time.com/3265187/e-cigarettes-gateway-drug/","keywords":["Addiction","Smoking","E-Cigarettes","Research","e-cigs","Nicotine"],"thumbnailUrl":"https://static.time.com/v3/assets/bltea6093859af6183b/bltbcf47d77b4cce5d9/6986832be8524b1b536018fb/ecigarette-france.jpg?branch=production&width=1200&quality=75&auto=webp&crop=1200:675&height=675","author":[{"@type":"Person","name":"Mandy Oaklander","jobTitle":"Oaklander is a senior editor at TIME.","url":"https://time.com/author/mandy-oaklander/"}],"articleSection":"Health","image":[{"@type":"ImageObject","url":"https://static.time.com/v3/assets/bltea6093859af6183b/bltbcf47d77b4cce5d9/6986832be8524b1b536018fb/ecigarette-france.jpg?branch=production&width=1200&quality=75&auto=webp&crop=1200:675&height=675","width":1200,"height":675,"headline":"An e-cigarette on March 05, 2013 in Paris.","caption":"An e-cigarette on March 05, 2013 in Paris.","creditText":"Kenzo Tribouillard—AFP/Getty Images","representativeOfPage":true}],"publisher":{"@type":"Organization","name":"Time","url":"https://time.com/","logo":{"@type":"ImageObject","url":"https://time.com/images/logo.png","width":528,"height":156},"foundingDate":"March 3, 1923","sameAs":["https://www.facebook.com/time","https://www.instagram.com/time/?hl=en","https://twitter.com/time","https://www.pinterest.com/timemagazine"]}},{"@context":"https://schema.org","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"/section/health/","name":"Health"}},{"@type":"ListItem","position":2,"item":{"@id":"/tag/addiction/","name":"Addiction"}},{"@type":"ListItem","position":3,"item":{"@id":"https://time.com/3265187/e-cigarettes-gateway-drug/","name":"E-Cigarettes Are Gateway to Substance Abuse and Addiction"}}]}] ```